The Gates Foundation is part of the Grand Challenges partnership network. Visit <a href="https://www.grandchallenges.org" target="_blank">www.grandchallenges.org</a> to view the map of awarded grants across this network and grant opportunities from partners.

Grand Challenges supports exceptional scientists with the expertise to do breakthrough R&amp;D as well as the experience, networks, and skills to excel as scientific leaders. These champions co-create projects with global partners, mobilize key institutions in their countries, and improve public health in their communities and around the world.

Grand Challenges funds innovations to tackle the biggest problems in global health and development. Since 2004, through the Grand Challenges program, we have supported more than 2500 innovation projects in more than 90 countries.

For more than 20 years, Grand Challenges has built trusted relationships with global health funders and researchers. We tap into this powerful network to create unique scientific collaborations with a transformative impact on people's lives.

Innovation happens all along the journey from idea, to experiment, to product or policy, and finally to delivery at scale in communities. We fund innovation projects while supporting an environment of champions, systems, and partnerships to maximize the impact these projects make in people's lives.

The 4 Pillars of the Grand Challenges Ecosystem

Doing groundbreaking science requires the right mix of institutions, policies, and tools. Grand Challenges works with partners in low- and middle-income countries to build or strengthen the capacities they need to succeed in R&amp;D.

Open Grant Opportunities

Run For Her - “No woman should die giving life”

On a recent Sunday morning, about 50,000 runners packed the streets of Nairobi and 25 other counties across Kenya to raise awareness about postpartum hemorrhage, the leading cause of maternal death.Moses Obimbo, a <a href="https://contentpreview-spoke.grandchallenges.org/champion/moses-obimbo-madadi" target="_blank">Calestous Juma fellow</a> and practicing ob-gyn, began organizing the run three years ago to break the culture of silence surrounding PPH in Kenya. He hoped awareness would lead to community ownership and action. The government has since released plans to reduce preventable maternal, neonatal, and stillbirth deaths by 15% across 26 hotspot counties within two years.This year, organizers also set up blood donation sites at the finish lines. They collected 3,350 units of blood - enough to save about 1,500 women from death or organ failure."I really believe in the power of the people. When we all push for something to be done and work as a team, then it's possible to save our mothers," said Moses.

We challenge innovators around the world to work on urgent priorities in global health and development. We issue new challenges regularly and award the most promising proposals with grant funding.&nbsp;

Past Challenges

**NOTE: This opportunity was open only to institutions who had been invited directly by email.Before applying, applicants should familiarize themselves with the supporting documents for this Grand Challenge, including the <a href="https://gcgh.grandchallenges.org/sites/default/files/files/cholera_modeling_rules_and_guidlines.pdf" target="_blank">Rules and Guidelines</a>, <a href="https://gcgh.grandchallenges.org/sites/default/files/files/cholera_modeling_application_instructions.pdf" target="_blank">Application Instructions</a>, and <a href="https://gcgh.grandchallenges.org/sites/default/files/files/cholera_modeling_faqs.pdf" target="_blank">Frequently Asked Questions</a>.<h2>Background</h2>Cholera continues to impact multiple countries, some presenting with transmission in endemic areas, some in outbreak-prone hotspots, and some with both endemic and epidemic transmission patterns. Interventions should include improving access to clean water in Priority Areas for Multisectoral Interventions (PAMIs), and reactive and/or preventive oral cholera vaccine (OCV) use. Yet, these interventions are expensive in the face of decreased global funding for vaccines and international aid. Countries have to weigh alternative interventions, and better target interventions to minimize costs, and such policy decisions could be informed by modeling.There is a significant disconnect between desired simplicity in outputs by some country partners v/s the capabilities of models and nuances in interpreting outputs. In countries where sub-national surveillance data exist, in-country modeling expertise can be leveraged to enhance cholera modeling capacity, while also working with cholera modeling technical experts to further develop tools relevant for local questions and locally available data.Through this RFP, we aim to fund a consortium approach to tackle these issues in 3 countries.<drupal-media data-entity-type="media" data-entity-uuid="1803c67a-2ef7-47d4-aacf-415a92abbcd4">&nbsp;</drupal-media>Our goals are to:<ul><li data-list-item-id="ec85ac7d69fef9bcab164b18d23416d68">Accelerate impactful in-country use of subnational cholera data for decision-making: accelerate real-time assessment of cholera risk and burden, enable efficient OCV and Water Sanitation and Hygiene (WASH) response planning, and strengthen iterative feedback from data à decisions</li><li data-list-item-id="e04d27b2ec1c7d624a24d27bba0c71b09">Foster multi-country coordination/communication and sharing on useful tools, visualizations, AI-enabled approaches as work progresses</li><li data-list-item-id="ee262add488943fc8d6e75b4f1b1d605a">Create sustainable structure and demonstrate value of using underutilized data to ministries of health</li></ul><h2>The Challenge</h2>This RFP seeks to leverage existing disease modeling capacity in the country to undertake cholera modeling using local data to address locally relevant questions to inform decision-making in cholera control.<ul><li data-list-item-id="e9d9394d548b9ee80e0785e8ee57a8bee">The RFP is only open to modelers and partners based in the country where cholera data are to be analyzed and modeled.</li></ul>Specifically, the objectives of the challenge will be:<ul><li data-list-item-id="e0595baee47c00e11f039b5b1480ce544">Address pressing policy-relevant questions to inform cholera control in the country</li><li data-list-item-id="e4be088c1c36301267d78bafc561b7053">Enhance capacity amongst modelers to undertake cholera modeling in collaboration with cholera decision-makers in government</li><li data-list-item-id="ee59c746b7b02e4b33c0a42a47d438df2">Utilize existing cholera surveillance data in country to understand risk and target interventions</li><li data-list-item-id="eeb11a33b5f86afd95b1f6a518944e600">Build capacity among policy makers to engage with and use modeling support to inform decision-making</li><li data-list-item-id="ee70451a47e08ade295f17821ad79434d">Promote leadership and independence in cholera modeling</li><li data-list-item-id="e12c93f75adce845909df12e1d4e87c6e">Build an international cohort of cholera modelers and policy makers who can exchange methods and learnings</li><li data-list-item-id="e1c684d0eae8c541215a728dca6eabdf5">Inform policy and program decision-making via scalable tools</li><li data-list-item-id="e5509dbccc114b7955259d531a97963e0">Leverage AI to create scalable and sustainable data à decision processes</li></ul>Funding LevelWe will consider proposals for awards of up to $500,000 USD (inclusive of indirect costs) for each project, with a grant term of up to 3 years. Application budgets should be commensurate with the scope of work proposed. Indirect costs should be included within this total budget, up to a maximum of 15% of the award (subject to the <a href="https://docs.gatesfoundation.org/Documents/Indirect_Cost_Policy.pdf" target="_blank">Gates Foundation's indirect cost policy</a>).Eligibility CriteriaThis initiative is open to nonprofit organizations, for-profit companies, government institutes and agencies, and academic institutions that 1) are based in one of the listed cholera-impacted countries<a href="#_ftn1" id="_ftnref1" name="_ftnref1">1</a>; and 2) have existing relations with government decision-makers and entities holding cholera surveillance data. Applicants should be able to show access to cholera surveillance data and should align with their decision-makers and institutions before submitting a proposal as no more than one award will be given to a single institution.We are looking for proposals that:&nbsp;<ul><li data-list-item-id="ef52d1002ef071f8fa3395d0de8f2c277">Are led by an organization with existing expertise and/or experience in infectious disease modeling that: 1) have access to sub-national cholera surveillance data in the country (must clarify the administrative level at which data are available), 2) have existing relationships with organizations/institutes engaged in cholera surveillance, and 3) have existing relationships or are willing to network with cholera decision-makers in the country.</li><li data-list-item-id="e8cc37f960c49646ec65fad4ba29a9859">Focus on cholera modeling, with a focus including but not limited to outbreak prediction and forecasting, scenario analysis to inform choice of intervention and geographic prioritization for interventions, and cost-effectiveness analyses of alternative interventions. Applicants must utilize methods that clearly link subnational data to decision-making, and can include but should move beyond risk stratification across the country, to utilize approaches to enable evaluation across intervention arms and strategies.</li><li data-list-item-id="e67caf7e157c0c21fcf382e4f66a717b2">Prioritize policy-relevant modeling questions.&nbsp;</li><li data-list-item-id="eb17d0c25252dee847b17ae96049f3b08">Demonstrate institutional support and partnerships necessary for collaborative work with country surveillance leads and decision-makers.</li><li data-list-item-id="e0960ce7db4731fad88f1bb456bc7610b">Conduct analyses beyond what has already been funded and/or published.&nbsp;</li><li data-list-item-id="ec9262919f7edc12175160111ced03ace">Result in at least three policy briefs.&nbsp;</li><li data-list-item-id="e87b2d61be95b18fc6cd184a4cc490b68">Investigators should be willing to work with international cholera modeling technical partners, and to present their methods and insights in meetings with other technical leads and policy makers in this cohort. Policy leads should be willing to undertake a fellowship program designed to build understanding and expertise in engaging with modelers to address pressing policy questions. These resources will be supported by a separate grant to international partners directly from the Gates Foundation.</li><li data-list-item-id="eb14ce7919cd573f417043a47d02bf829">Contribute to sustainable capacity for cholera modeling to be available to policy makers, and to be conducted independently in the future.</li></ul>We will not fund proposals that:&nbsp;<ul><li data-list-item-id="efc382db580bc3c57b3b3e531c0de71a1">Aim to collect or generate new data through this funding.</li><li data-list-item-id="e85026b73a92917f5e0a74613238757bb">Propose descriptive analyses alone.</li><li data-list-item-id="e0a1383cc7574c690f970d07bacc7335c">Propose analyses that overlap with results already funded and/or published.</li><li data-list-item-id="e789521be65b8b0ef98b38f07d4b4b0b9">Are not led by a country-based investigator.</li><li data-list-item-id="e6ceb11a33e6b00866931ab459922f456">Do not demonstrate how the investigator has access to sub-national cholera surveillance data in country</li><li data-list-item-id="e2f51218bcf312d2af44c7913063b2011">Do not demonstrate existing or planned engagement with country policy makers&nbsp;</li><li data-list-item-id="ebd7603de6d0fb178131c5739d731b703">Do not demonstrate willingness to build a network in country focused on using modeling to address cholera policy questions&nbsp;</li><li data-list-item-id="e52486fb9479a86dcaf0ebfb43c9cfd51">Do not demonstrate a clear commitment to engaging in training led by international partners in cholera modeling and modeling use by policy makers.</li></ul><a href="#_ftnref1" id="_ftn1" name="_ftn1">1</a> Bangladesh; Burundi; DRC; Ethiopia; India; Kenya; Malawi; Mozambique; Nigeria; Zambia

Grand Challenges

Strengthening Country-Led Cholera Modeling for Evidence-Based Policy Decisions

**NOTE: This opportunity is open only to institutions who have been invited directly by email.
Before applying, applicants should familiarize themselves with the supporting documents for this Grand Challenge, including the <a href="https://gcgh.grandchallenges.org/sites/default/files/files/cholera_modeling_rules_and_guidlines.pdf" target="_blank" rel="noopener noreferrer">Rules and Guidelines</a>, <a href="https://gcgh.grandchallenges.org/sites/default/files/files/cholera_modeling_application_instructions.pdf" target="_blank" rel="noopener noreferrer">Application Instructions</a>, and <a href="https://gcgh.grandchallenges.org/strengthening-country-led-cholera-modeling-evidence-based-policy-decisions" target="_blank" rel="noopener noreferrer">Frequently Asked Questions</a>.
<h2>Background</h2>
Cholera continues to impact multiple countries, some presenting with transmission in endemic areas, some in outbreak-prone hotspots, and some with both endemic and epidemic transmission patterns. Interventions should include improving access to clean water in Priority Areas for Multisectoral Interventions (PAMIs), and reactive and/or preventive oral cholera vaccine (OCV) use. Yet, these interventions are expensive in the face of decreased global funding for vaccines and international aid. Countries have to weigh alternative interventions, and better target interventions to minimize costs, and such policy decisions could be informed by modeling.
There is a significant disconnect between desired simplicity in outputs by some country partners v/s the capabilities of models and nuances in interpreting outputs. In countries where sub-national surveillance data exist, in-country modeling expertise can be leveraged to enhance cholera modeling capacity, while also working with cholera modeling technical experts to further develop tools relevant for local questions and locally available data.
Through this RFP, we aim to fund a consortium approach to tackle these issues in 3 countries.
<div class="media media--type-image media--view-mode-default">
 
 
 <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/images/picture1_0.png" width="975" height="617" alt="Cholera Modeling Graphic">

</div>
 
 </div>
Our goals are to:
<ul>
<li>Accelerate impactful in-country use of subnational cholera data for decision-making: accelerate real-time assessment of cholera risk and burden, enable efficient OCV and Water Sanitation and Hygiene (WASH) response planning, and strengthen iterative feedback from data à decisions</li>
<li>Foster multi-country coordination/communication and sharing on useful tools, visualizations, AI-enabled approaches as work progresses</li>
<li>Create sustainable structure and demonstrate value of using underutilized data to ministries of health</li>
</ul>
<h2>The Challenge</h2>
This RFP seeks to leverage existing disease modeling capacity in the country to undertake cholera modeling using local data to address locally relevant questions to inform decision-making in cholera control.
<ul>
<li>The RFP is only open to modelers and partners based in the country where cholera data are to be analyzed and modeled.</li>
</ul>
Specifically, the objectives of the challenge will be:
<ul>
<li>Address pressing policy-relevant questions to inform cholera control in the country</li>
<li>Enhance capacity amongst modelers to undertake cholera modeling in collaboration with cholera decision-makers in government</li>
<li>Utilize existing cholera surveillance data in country to understand risk and target interventions</li>
<li>Build capacity among policy makers to engage with and use modeling support to inform decision-making</li>
<li>Promote leadership and independence in cholera modeling</li>
<li>Build an international cohort of cholera modelers and policy makers who can exchange methods and learnings</li>
<li>Inform policy and program decision-making via scalable tools</li>
<li>Leverage AI to create scalable and sustainable data à decision processes</li>
</ul>
Funding Level
We will consider proposals for awards of up to $500,000 USD (inclusive of indirect costs) for each project, with a grant term of up to 3 years. Application budgets should be commensurate with the scope of work proposed. Indirect costs should be included within this total budget, up to a maximum of 15% of the award (subject to the <a href="https://docs.gatesfoundation.org/Documents/Indirect_Cost_Policy.pdf" target="_blank" rel="noopener noreferrer">Gates Foundation's indirect cost policy</a>).
Eligibility Criteria
This initiative is open to nonprofit organizations, for-profit companies, government institutes and agencies, and academic institutions that 1) are based in one of the listed cholera-impacted countries<a href="#_ftn1" id="_ftnref1" name="_ftnref1">1</a>; and 2) have existing relations with government decision-makers and entities holding cholera surveillance data. Applicants should be able to show access to cholera surveillance data and should align with their decision-makers and institutions before submitting a proposal as no more than one award will be given to a single institution.
We are looking for proposals that:&nbsp;
<ul>
<li>Are led by an organization with existing expertise and/or experience in infectious disease modeling that: 1) have access to sub-national cholera surveillance data in the country (must clarify the administrative level at which data are available), 2) have existing relationships with organizations/institutes engaged in cholera surveillance, and 3) have existing relationships or are willing to network with cholera decision-makers in the country.</li>
<li>Focus on cholera modeling, with a focus including but not limited to outbreak prediction and forecasting, scenario analysis to inform choice of intervention and geographic prioritization for interventions, and cost-effectiveness analyses of alternative interventions. Applicants must utilize methods that clearly link subnational data to decision-making, and can include but should move beyond risk stratification across the country, to utilize approaches to enable evaluation across intervention arms and strategies.</li>
<li>Prioritize policy-relevant modeling questions.&nbsp;</li>
<li>Demonstrate institutional support and partnerships necessary for collaborative work with country surveillance leads and decision-makers.</li>
<li>Conduct analyses beyond what has already been funded and/or published.&nbsp;</li>
<li>Result in at least three policy briefs.&nbsp;</li>
<li>Investigators should be willing to work with international cholera modeling technical partners, and to present their methods and insights in meetings with other technical leads and policy makers in this cohort. Policy leads should be willing to undertake a fellowship program designed to build understanding and expertise in engaging with modelers to address pressing policy questions. These resources will be supported by a separate grant to international partners directly from the Gates Foundation.</li>
<li>Contribute to sustainable capacity for cholera modeling to be available to policy makers, and to be conducted independently in the future.</li>
</ul>
We will not fund proposals that:&nbsp;
<ul>
<li>Aim to collect or generate new data through this funding.</li>
<li>Propose descriptive analyses alone.</li>
<li>Propose analyses that overlap with results already funded and/or published.</li>
<li>Are not led by a country-based investigator.</li>
<li>Do not demonstrate how the investigator has access to sub-national cholera surveillance data in country</li>
<li>Do not demonstrate existing or planned engagement with country policy makers&nbsp;</li>
<li>Do not demonstrate willingness to build a network in country focused on using modeling to address cholera policy questions&nbsp;</li>
<li>Do not demonstrate a clear commitment to engaging in training led by international partners in cholera modeling and modeling use by policy makers.</li>
</ul>
<a href="#_ftnref1" id="_ftn1" name="_ftn1">1</a> Bangladesh; Burundi; DRC; Ethiopia; India; Kenya; Malawi; Mozambique; Nigeria; Zambia

**NOTE: This opportunity is open only to institutions who have been invited directly by email.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

This Grand Challenge initiative seeks to accelerate the development of low-cost, streamlined, and operationally simple targeted pathogen sequencing workflows designed for routine public health use in LMICs. We invite researchers and innovators to propose bold, scalable solutions that lower sequencing costs, simplify protocols, and democratize access to genomics.

Before applying to this Grand Challenges request for proposals (RFP), applicants should familiarize themselves with the supporting documents, including the <a href="https://docs.gatesfoundation.org/documents/sample-terms-and-conditions.pdf" target="_blank">terms and conditions of the Gates Foundation</a>, the <a href="https://gcgh.grandchallenges.org/sites/default/files/files/ai_consumer_engagement_for_family_planning_rules_and_guidelines.pdf" target="_blank">Rules and Guidelines</a>, <a href="https://gcgh.grandchallenges.org/sites/default/files/files/ai_consumer_engagement_for_family_planning_application_instructions.pdf" target="_blank">Application Instructions</a>, and <a href="https://gcgh.grandchallenges.org/sites/default/files/files/ai_consumer_engagement_for_family_planning_faqs.pdf" target="_blank">Frequently Asked Questions (FAQs)</a>.If you plan to apply to this RFP, we will host a dedicated <a href="https://events.teams.microsoft.com/event/ac4a79a3-e3f8-4878-8384-7f4a6a2fc759@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank">webinar</a> on August 4, 2026, 7:00-8:00 a.m. US PDT. The session will provide an overview of the RFP and include time for questions. To attend, please <a href="https://events.teams.microsoft.com/event/ac4a79a3-e3f8-4878-8384-7f4a6a2fc759@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank">register</a> and <a href="https://forms.cloud.microsoft/Pages/ResponsePage.aspx?id=ODhrKdVLbEm9S_RW6nQ7dNyUf4PhutFBmFMAT6JKpddUNFc3TjhIQ05MMTVJUVJSWDg4MkVZOEE0Ty4u" target="_blank">submit your questions in advance</a>. A recording will be posted on the challenge page following the session for those unable to join live.<h2>Background</h2>Despite significant investment in family planning programs across sub-Saharan Africa, unmet need for contraception remains high. Women and girls face persistent barriers to accessing accurate, personalized information about family planning - barriers that clinic-based counseling alone cannot overcome at the scale and cost required to meaningfully shift contraceptive prevalence. Digital tools have expanded reach, but most existing approaches rely on one-way or rule-based messaging that cannot replicate the kind of responsive, personalized conversation that moves women from awareness to action.Recent advances in large language models have changed what is possible. Artificial Intelligence (AI)-enabled consumer engagement tools can now hold nuanced, multi-turn conversations in local languages, respond to individual questions and concerns, and deliver personalized information at very low marginal cost across both public and private sector channels. Platforms with existing distribution - through telecoms, government health systems, community networks, and commercial channels - are beginning to deploy these tools at scale across the region, often serving broad women's health and consumer health needs that could extend to family planning.What the field lacks is evidence. We do not yet know which AI-enabled engagement approaches work best to drive contraceptive uptake and continuation, which conversation features and content strategies make the difference, or how to evaluate interaction quality in ways that predict real outcomes. Without that understanding, investments in AI-enabled family planning tools cannot be optimized, replicated, or responsibly scaled. This challenge is designed to generate that evidence - and to build the shared analytic foundation the field needs to learn from it.<h2>The Challenge</h2>This RFP seeks to answer a core question for the family planning field: can AI-enabled direct-to-consumer engagement improve contraceptive uptake, continuation, and informed method choice at scale - and, if so, which approach works best?This challenge is designed to generate practical evidence on what high-quality, AI-assisted family planning engagement looks like in the AI era. We are interested in understanding which AI-enabled tools are most effective to engage users and improve contraception uptake and continuation. More specifically, we are interested in understanding which tools and approaches (e.g., content personalization, rapid content scaling, automated customer journeys, etc.) work best for which types of users to directly engage them and improve uptake and which platforms/tools have demonstrated less success for this objective. We do not expect applicants to arrive with platforms already proven for contraception; we welcome consumer engagement approaches with a demonstrated track record in women's health or consumer health more broadly, and ask applicants to deploy, test, and assess how well they work for family planning.The challenge will focus on women and girls of reproductive age in sub-Saharan Africa. Interventions can be delivered through public sector platforms, private sector channels, or hybrid models.Applicants must be able to measure the quality and characteristics of the AI-enabled interaction, scale and usage, and the user outcomes that occur after the interaction. Successful proposals should demonstrate a credible pathway between AI-enabled engagement and family planning outcomes, while also contributing to learning that can inform the broader field. Applicants should be prepared to assess not only whether the intervention changed behavior, but how and why.ObjectivesThe objectives of this challenge are to:<ol><li data-list-item-id="e710c6c87d3a01740289f609b6f3317d4">Generate evidence on impact and scale. Demonstrate whether and how AI-enabled direct-to-consumer engagement improves contraceptive uptake, method continuation, and/or informed method choice at scale.</li><li data-list-item-id="e35e5cb1c13dd43e10f315703bca20725">Identify the features of effective engagement. Determine which interaction characteristics, content strategies, personalization approaches, prompts, follow-up models, or conversation patterns are associated with stronger user outcomes.</li><li data-list-item-id="e3771db4ac2f8487df0f7ebbabe0fc733">Build a shared evidence base for AI-enabled family planning engagement. Produce labeled conversation examples, interaction taxonomies, quality rubrics, safety, confidentiality, and guardrail protocols, and/or other analytic tools that can help the field evaluate and improve AI-enabled consumer engagement beyond a single program or platform.</li><li data-list-item-id="eb3947950669686ac0b2e33b4d694df63">Assess cost, feasibility, and added value. Document the cost, operational requirements, feasibility, and comparative value of AI-enabled engagement relative to alternative consumer engagement or demand-generation models, including the conditions under which AI-enabled approaches are likely to add meaningful value.</li></ol>Proposals should be designed to produce both programmatic results and field-building insights. The strongest applications will combine a compelling intervention model with a rigorous approach to measurement, a clear plan for analyzing interaction quality, and a commitment to generating practical learning that can inform future investments in AI-enabled family planning tools.Funding LevelWe will consider proposals for awards of up to $500,000 USD for each project, with a grant term of up to 12 months. Application budgets should be commensurate with the scope of work proposed. Indirect costs may be included in the budget, up to a maximum of 15% of the total budget (subject to the <a href="https://docs.gatesfoundation.org/Documents/Indirect_Cost_Policy.pdf" target="_blank" title="https://docs.gatesfoundation.org/documents/indirect_cost_policy.pdf">Gates Foundation's indirect cost policy</a>).Eligibility CriteriaThis initiative is open globally to nonprofit organizations, for-profit companies, international organizations, government agencies and academic institutions. Multi stakeholder collaborations are encouraged. Individuals and organizations classified as individuals for U.S. tax purposes are not eligible to receive an award from the foundation as part of this initiative.We are looking for proposals that:<ul><li data-list-item-id="e06cf7097e8ad1e40aae097447b044d31">Applicants should have existing women’s/ consumer health intervention cohorts in Nigeria, Ethiopia, the Democratic Republic of Congo, Tanzania, Senegal, Niger, Kenya, South Africa, Zambia or Côte d’Ivoire.</li><li data-list-item-id="e0d63a2e37be552f0c2271af6361b87e9">Applicants should have an existing consumer engagement approach - in family planning, women's health, or consumer health more broadly - and an established user base or distribution relationship - characterized by engagement (e.g., monthly active users), not size alone - ideally in at least one target geography at the time of application</li><li data-list-item-id="ec7d92e33d687c4501c78a55ec73f35a2">The AI-enabled engagement approach itself can be new and innovative, but the grant period should be spent on deployment, learning, and evaluation, not on acquiring users or negotiating platform access</li><li data-list-item-id="e246e5ee470530057fb2de84362c5b413">Propose a credible evaluation design that measures the quality, safety, and confidentiality of the AI-enabled interaction and downstream user outcomes, including contraceptive uptake, method continuation, or informed method choice</li><li data-list-item-id="ecb252dee32c38ada115a5de04fbc0472">Have a clear theory of what effective engagement looks like and how interaction quality connects to behavior change - and a plan to test it</li><li data-list-item-id="e0c94042548d36da2742185291c8ba689">Operate at sufficient scale to generate meaningful findings within the grant period</li><li data-list-item-id="e3dc987e1382f7b753d114ce2081bf4a9">Commit to producing outputs that contribute to the shared evidence base - including but not limited to labeled interaction examples, conversation quality rubrics, interaction taxonomies, or safety, confidentiality, and guardrail protocols</li><li data-list-item-id="e6af423bbdf4a99d1612f641bb4e9b662">Demonstrate that AI-generated content is grounded in vetted, locally relevant family planning information aligned with national MOH or WHO guidelines</li><li data-list-item-id="e80ffff4c428f9bf2c7a2e6592cf3df06">Are led by organizations with deep contextual knowledge of the target geography and population</li><li data-list-item-id="e0b68135de1c09e152d74394ea8a6e9c2">Define their target user and explain how relevant their existing user base is to family planning outcomes - particularly for solutions not originally focused on family planning</li><li data-list-item-id="e0cf85366e10aab74a887b45cd24ca880">Describe their user acquisition model, including key metrics, and their user retention efforts - recognizing that engagement quality and the human touchpoints before and after the digital interaction matter as much to family planning outcomes as user-base size</li></ul>We will not fund proposals that:<ul><li data-list-item-id="e84df7aa3525d6fe0603150f1599cac7a">Rely on engagement metrics alone - sessions completed, messages sent, users registered - as primary evidence of effectiveness</li><li data-list-item-id="ee1fbce0f147257b1c061e85401a3487d">Lack an existing user base or distribution relationship in a target geography at the time of application</li><li data-list-item-id="e0cc03beb6d84d4b9609edbf5421c256c">Propose work outside of sub-Saharan Africa. Preference for solutions targeting Nigeria, Ethiopia, the Democratic Republic of Congo, Tanzania, Senegal, Niger, or Côte d'Ivoire</li><li data-list-item-id="ed53fac7f1fdbf27292186b2f2cc3b6e0">Are primarily research-led without a real-world operational deployment component at scale</li></ul>

AI-Enabled Consumer Engagement to Advance Family Planning

Before applying to this Grand Challenges request for proposals (RFP), applicants should familiarize themselves with the supporting documents, including the <a href="https://docs.gatesfoundation.org/documents/sample-terms-and-conditions.pdf" target="_blank" rel="noopener noreferrer">terms and conditions of the Gates Foundation</a>, the <a href="https://gcgh.grandchallenges.org/sites/default/files/files/ai_consumer_engagement_for_family_planning_rules_and_guidelines.pdf" target="_blank" rel="noopener noreferrer">Rules and Guidelines</a>, <a href="https://gcgh.grandchallenges.org/sites/default/files/files/ai_consumer_engagement_for_family_planning_application_instructions.pdf" target="_blank" rel="noopener noreferrer">Application Instructions</a>, and <a href="https://gcgh.grandchallenges.org/ai-enabled-consumer-engagement-advance-family-planning-frequently-asked-questions-faqs" target="_blank" rel="noopener noreferrer">Frequently Asked Questions (FAQs)</a>.
If you plan to apply to this RFP, we will host a dedicated <a href="https://events.teams.microsoft.com/event/ac4a79a3-e3f8-4878-8384-7f4a6a2fc759@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank" rel="noopener noreferrer">webinar</a> on August 4, 2026, 7:00-8:00 a.m. US PDT. The session will provide an overview of the RFP and include time for questions. To attend, please <a href="https://events.teams.microsoft.com/event/ac4a79a3-e3f8-4878-8384-7f4a6a2fc759@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank" rel="noopener noreferrer">register</a> and <a href="https://forms.cloud.microsoft/Pages/ResponsePage.aspx?id=ODhrKdVLbEm9S_RW6nQ7dNyUf4PhutFBmFMAT6JKpddUNFc3TjhIQ05MMTVJUVJSWDg4MkVZOEE0Ty4u" target="_blank" rel="noopener noreferrer">submit your questions in advance</a>. A recording will be posted on the challenge page following the session for those unable to join live.
<h2>Background</h2>
Despite significant investment in family planning programs across sub-Saharan Africa, unmet need for contraception remains high. Women and girls face persistent barriers to accessing accurate, personalized information about family planning - barriers that clinic-based counseling alone cannot overcome at the scale and cost required to meaningfully shift contraceptive prevalence. Digital tools have expanded reach, but most existing approaches rely on one-way or rule-based messaging that cannot replicate the kind of responsive, personalized conversation that moves women from awareness to action.
Recent advances in large language models have changed what is possible. Artificial Intelligence (AI)-enabled consumer engagement tools can now hold nuanced, multi-turn conversations in local languages, respond to individual questions and concerns, and deliver personalized information at very low marginal cost across both public and private sector channels. Platforms with existing distribution - through telecoms, government health systems, community networks, and commercial channels - are beginning to deploy these tools at scale across the region, often serving broad women's health and consumer health needs that could extend to family planning.
What the field lacks is evidence. We do not yet know which AI-enabled engagement approaches work best to drive contraceptive uptake and continuation, which conversation features and content strategies make the difference, or how to evaluate interaction quality in ways that predict real outcomes. Without that understanding, investments in AI-enabled family planning tools cannot be optimized, replicated, or responsibly scaled. This challenge is designed to generate that evidence - and to build the shared analytic foundation the field needs to learn from it.
<h2>The Challenge</h2>
This RFP seeks to answer a core question for the family planning field: can AI-enabled direct-to-consumer engagement improve contraceptive uptake, continuation, and informed method choice at scale - and, if so, which approach works best?
This challenge is designed to generate practical evidence on what high-quality, AI-assisted family planning engagement looks like in the AI era. We are interested in understanding which AI-enabled tools are most effective to engage users and improve contraception uptake and continuation. More specifically, we are interested in understanding which tools and approaches (e.g., content personalization, rapid content scaling, automated customer journeys, etc.) work best for which types of users to directly engage them and improve uptake and which platforms/tools have demonstrated less success for this objective. We do not expect applicants to arrive with platforms already proven for contraception; we welcome consumer engagement approaches with a demonstrated track record in women's health or consumer health more broadly, and ask applicants to deploy, test, and assess how well they work for family planning.
The challenge will focus on women and girls of reproductive age in sub-Saharan Africa. Interventions can be delivered through public sector platforms, private sector channels, or hybrid models.
Applicants must be able to measure the quality and characteristics of the AI-enabled interaction, scale and usage, and the user outcomes that occur after the interaction. Successful proposals should demonstrate a credible pathway between AI-enabled engagement and family planning outcomes, while also contributing to learning that can inform the broader field. Applicants should be prepared to assess not only whether the intervention changed behavior, but how and why.
Objectives
The objectives of this challenge are to:
<ol>
<li>Generate evidence on impact and scale. Demonstrate whether and how AI-enabled direct-to-consumer engagement improves contraceptive uptake, method continuation, and/or informed method choice at scale.</li>
<li>Identify the features of effective engagement. Determine which interaction characteristics, content strategies, personalization approaches, prompts, follow-up models, or conversation patterns are associated with stronger user outcomes.</li>
<li>Build a shared evidence base for AI-enabled family planning engagement. Produce labeled conversation examples, interaction taxonomies, quality rubrics, safety, confidentiality, and guardrail protocols, and/or other analytic tools that can help the field evaluate and improve AI-enabled consumer engagement beyond a single program or platform.</li>
<li>Assess cost, feasibility, and added value. Document the cost, operational requirements, feasibility, and comparative value of AI-enabled engagement relative to alternative consumer engagement or demand-generation models, including the conditions under which AI-enabled approaches are likely to add meaningful value.</li>
</ol>
Proposals should be designed to produce both programmatic results and field-building insights. The strongest applications will combine a compelling intervention model with a rigorous approach to measurement, a clear plan for analyzing interaction quality, and a commitment to generating practical learning that can inform future investments in AI-enabled family planning tools.
Funding Level
We will consider proposals for awards of up to $500,000 USD for each project, with a grant term of up to 12 months. Application budgets should be commensurate with the scope of work proposed. Indirect costs may be included in the budget, up to a maximum of 15% of the total budget (subject to the <a href="https://docs.gatesfoundation.org/Documents/Indirect_Cost_Policy.pdf" target="_blank" title="https://docs.gatesfoundation.org/documents/indirect_cost_policy.pdf" rel="noopener noreferrer">Gates Foundation's indirect cost policy</a>).
Eligibility Criteria
This initiative is open globally to nonprofit organizations, for-profit companies, international organizations, government agencies and academic institutions. Multi stakeholder collaborations are encouraged. Individuals and organizations classified as individuals for U.S. tax purposes are not eligible to receive an award from the foundation as part of this initiative.
We are looking for proposals that:
<ul>
<li>Applicants should have existing women’s/ consumer health intervention cohorts in Nigeria, Ethiopia, the Democratic Republic of Congo, Tanzania, Senegal, Niger, Kenya, South Africa, Zambia or Côte d’Ivoire.</li>
<li>Applicants should have an existing consumer engagement approach - in family planning, women's health, or consumer health more broadly - and an established user base or distribution relationship - characterized by engagement (e.g., monthly active users), not size alone - ideally in at least one target geography at the time of application</li>
<li>The AI-enabled engagement approach itself can be new and innovative, but the grant period should be spent on deployment, learning, and evaluation, not on acquiring users or negotiating platform access</li>
<li>Propose a credible evaluation design that measures the quality, safety, and confidentiality of the AI-enabled interaction and downstream user outcomes, including contraceptive uptake, method continuation, or informed method choice</li>
<li>Have a clear theory of what effective engagement looks like and how interaction quality connects to behavior change - and a plan to test it</li>
<li>Operate at sufficient scale to generate meaningful findings within the grant period</li>
<li>Commit to producing outputs that contribute to the shared evidence base - including but not limited to labeled interaction examples, conversation quality rubrics, interaction taxonomies, or safety, confidentiality, and guardrail protocols</li>
<li>Demonstrate that AI-generated content is grounded in vetted, locally relevant family planning information aligned with national MOH or WHO guidelines</li>
<li>Are led by organizations with deep contextual knowledge of the target geography and population</li>
<li>Define their target user and explain how relevant their existing user base is to family planning outcomes - particularly for solutions not originally focused on family planning</li>
<li>Describe their user acquisition model, including key metrics, and their user retention efforts - recognizing that engagement quality and the human touchpoints before and after the digital interaction matter as much to family planning outcomes as user-base size</li>
</ul>
We will not fund proposals that:
<ul>
<li>Rely on engagement metrics alone - sessions completed, messages sent, users registered - as primary evidence of effectiveness</li>
<li>Lack an existing user base or distribution relationship in a target geography at the time of application</li>
<li>Propose work outside of sub-Saharan Africa. Preference for solutions targeting Nigeria, Ethiopia, the Democratic Republic of Congo, Tanzania, Senegal, Niger, or Côte d'Ivoire</li>
<li>Are primarily research-led without a real-world operational deployment component at scale</li>
</ul>

This RFP seeks to answer a core question for the family planning field: can AI-enabled direct-to-consumer engagement improve contraceptive uptake, continuation, and informed method choice at scale - and, if so, which approach works best?
This challenge is designed to generate practical evidence on what high-quality, AI-assisted family planning engagement looks like in the AI era. We are interested in understanding which AI-enabled tools are most effective to engage users and improve contraception uptake and continuation.

Before applying to this Grand Challenges request for proposals (RFP), applicants should familiarize themselves with the supporting documents, including the&nbsp;<a href="https://docs.gatesfoundation.org/documents/sample-terms-and-conditions.pdf" target="_blank">terms and conditions of the Gates Foundation</a>, the&nbsp;<a href="https://gcgh.grandchallenges.org/sites/default/files/files/indicators_of_micronutrient_status_rules_and_guidelines.pdf" target="_blank">Rules and Guidelines</a>,&nbsp;<a href="https://gcgh.grandchallenges.org/sites/default/files/files/indicators_of_micronutrient_status_application_instructions.pdf" target="_blank">Application Instructions</a>, and&nbsp;<a href="https://gcgh.grandchallenges.org/multiplex-platforms-assess-indicators-micronutrient-status-and-infection-and-inflammation" target="_blank">Frequently Asked Questions (FAQs)</a>.If you plan to apply to this RFP, we will host a dedicated&nbsp;<a href="https://events.teams.microsoft.com/event/87a5ecee-9e3c-417d-a46c-ab3012b9fa85@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank">webinar</a>&nbsp;on August 11, 2026, 7:00-8:00 a.m. US PDT. The session will provide an overview of the RFP and include time for questions. To attend, please <a href="https://events.teams.microsoft.com/event/87a5ecee-9e3c-417d-a46c-ab3012b9fa85@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank">register</a> and&nbsp;<a href="https://forms.cloud.microsoft/Pages/ResponsePage.aspx?id=ODhrKdVLbEm9S_RW6nQ7dNyUf4PhutFBmFMAT6JKpddUOVBQVzFaR041MFc4MEU0QkFDTEpUVEs1Qi4u" target="_blank">submit your questions in advance</a>. A recording will be posted on the challenge page following the session for those unable to join live.<h2>Background</h2>Vitamins and minerals, collectively referred to as micronutrients), play essential roles in human metabolism and are required for physical growth, cognitive development, immune function, and the recovery from infection. Micronutrient deficiencies, particularly among vulnerable groups in low- and middle-income countries (chiefly women of child-bearing age, especially during pregnancy and lactation, preschool-age children and older adults), constrain social and economic development and limit progress toward good health and well-being. These deficiencies may arise from insufficient dietary intake, from concurrent disease or parasitism, or from genetic traits that affect MN metabolism. Diagnosing their causes, magnitude, severity, and population prevalence is essential for designing appropriate treatments and interventions, and for monitoring their effectiveness and safety.Over the past fifty years, progress against several long-standing micronutrient deficiencies has been substantial. Goiter and cognitive impairment caused by iodine deficiency have largely disappeared with iodized salt and iodine supplementation in animal feed; survival and resistance to infection have improved through correction of vitamin A deficiency; and neural tube defects have fallen in many high-income countries through folic acid fortification and supplementation. Progress against iron deficiency and anemia has been more modest, in part because infection and inflammation impair iron absorption and utilization. Micronutrient status must therefore be assessed together with biomarkers of infection and inflammation. There is also a need to add bioindicators for micronutrients that are infrequently assessed but central to physiology: vitamins B2 and B12, for example, are essential for the conversion of folic acid into folate (the active form of vitamin B9) and for combined action as catalyzers of many enzymatic reactions. In non-affluent populations, B2 or B12 deficiency may be as important as B9 deficiency.Recent advances in immunological and molecular recognition technologies allow several bioindicators to be measured simultaneously. For example, the Quansys multiplex kit measures several analytes (soluble transferrin receptor, ferritin, retinol binding protein, thyroglobulin and the acute-phase proteins CRP and AGP) in a single microplate well. This is possible because these analytes are immunogenic proteins for which specific antibodies can be generated. Extending this approach to less immunogenic bioindicators may now be feasible using other analyte-binding molecules, such as folate-binding protein from milk or porcine plasma, the B12 intrinsic factor, and synthetic nucleotide sequences, including RNA or DNA) aptamers that bind small molecules. This Grand Challenge seeks novel approaches to extend analytical coverage, improve sensitivity and specificity, simplify measurement, reduce cost, and enable frequent monitoring of micronutrient status by local institutions. A multiplex assay works only for analytes of similar chemical nature and concentration, so the wider micronutrient panel under discussion for the MNBI (for example zinc, vitamin C and vitamin D) cannot simply be folded into a single platform; those analytes require different detection principles and belong to separate future workstreams. No single platform is expected to carry every analyte, and this challenge focuses on the multiplex-compatible set, allowing a complementary, separate plate where needed (for example, red-blood-cell folate).<h2>The Challenge</h2>Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of&nbsp;analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would&nbsp;also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations&nbsp;(women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.This challenge is structured around two alternatives,&nbsp;a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate <a href="https://gcgh.grandchallenges.org/sites/default/files/files/indicators_of_micronutrient_status_target_product_profile.pdf" target="_blank">Target Product Profile</a> for this platform, and applicants will be held to the relevant performance, cost and instrument targets.<table class="table"><thead><tr><th>Parameter</th><th>Alternative A - Minimum scope</th><th>Alternative B - Optimistic scope</th></tr></thead><tbody><tr><td>Analyte panel</td><td>Strengthen and modestly extend the current multiplex test. Measure: soluble transferrin receptor, ferritin, RBP4, thyroglobulin, plasma methyl-tetrahydrofolate (without cross-reactivity with folic acid; a complementary folic-acid-specific test may be proposed), holo-transcobalamin (without cross-reactivity with apo-transcobalamin and all-haptocorrin), CRP and AGP.</td><td>All Alternative A analytes, plus metabolites or proteins associated with vitamin B1 and B2 deficiency, and thyroid hormones. A complementary test for whole-folate vitamers in red blood cells may also be included, on a separate microtiter platform if needed.</td></tr><tr><td>Sample volume</td><td>≤10 µL plasma/serum</td><td>≤5 µL plasma/serum. Other specimen types, such as dried blood spots (DBS), may also be addressed as optimistic scope; see note below. Response (not optimization) in twice that volume of whole blood from the same individuals should also be measured and reported, together with hematocrit.</td></tr><tr><td>Analytical Precision (CV)</td><td>&lt;20% CV total; &lt;15% within-run at the functional analytical sensitivity covering the expected physiological range of each analyte</td><td>&lt;10% CV total; &lt;8% within-run at the functional analytical sensitivity covering the expected physiological range of each analyte</td></tr><tr><td>Analytical sensitivity (LoD)</td><td>sTfR: 2–30 mg/L&nbsp; Ferritin: 5–100 µg/L&nbsp; RBP4: 0.3–3.0 µmol/L&nbsp; Thyroglobulin: 10–100 µg/L&nbsp; Methyl-THF: 5–50 nmol/L&nbsp; Holo-transcobalamin: to be defined&nbsp; CRP: 1–30 mg/L&nbsp; AGP: 0.5–5 g/L&nbsp; &nbsp;&nbsp; &nbsp;&nbsp; &nbsp;</td><td>sTfR: 1–40 mg/L&nbsp; Ferritin: 2–200 µg/L&nbsp; RBP4: 0.2–4.0 µmol/L&nbsp; Thyroglobulin: 5–300 µg/L&nbsp; Methyl-THF: 2–100 nmol/L&nbsp; RBC folate: 100–2000 nmol/L&nbsp; Holo-transcobalamin: to be defined&nbsp; CRP: 1–50 mg/L&nbsp; AGP: 0.25–5 g/L&nbsp; Thyroid hormones, B1, B2: as required for satisfactory diagnostic performance</td></tr><tr><td>Accuracy (Bias / Trueness)</td><td>≤ 10% bias across the measuring range for all target analytes when tested against certified reference materials</td><td>≤ 5% bias across the measuring range for all target analytes when tested against certified reference materials</td></tr><tr><td>Concordance&nbsp;</td><td>≥90% concordance when measured against, validated laboratory immunoassays or analytical gold standard methods, for all target analytes</td><td>≥95% concordance when measured against, validated laboratory immunoassays or analytical gold standard methods, for all target analytes</td></tr><tr><td>Cost target</td><td>≤US$20 per sample for all analytes measured in duplicate (i.e., 2 wells). This ceiling is per sample for the full panel in duplicate, not per analyte.</td><td>≤US$20 per sample for all analytes measured in duplicate (i.e., 2 wells). Optimistic stretch goal: ≤US$10 per sample for the full panel in duplicate.</td></tr><tr><td>Instrument</td><td>Bench-top signal-detection device, ≤US$30,000 per unit.</td><td>Bench-top signal-detection device, ≤US$25,000 per unit.</td></tr><tr><td>Funding &amp; term</td><td>Awards up to US$200,000 per project; grant term up to 12 months.</td><td>Awards up to US$800,000 per project; grant term up to 24 months. Budgets and terms evaluated per project and commensurate with scope.</td></tr></tbody></table>Note on dried blood spots:&nbsp;application of these assays to dried blood spots is a distinct downstream study to be undertaken once the tests are developed, and is not part of the core development scope of either alternative. Sample-volume targets are included&nbsp;to keep this pathway open. Applicants with an integrated, DBS-capable approach may optionally submit DBS-readiness data; such data are invited but will not be scored.Specifically, the objectives of this challenge are to:<ul><li data-list-item-id="ec71dae7ebd73fcfb4af1ada5080fd4d2">Improve the current multiplex test for immunological determination of nutritional-status analytes, overcoming standard heterogeneity, widening the functional analytical range to the expected physiological values, and maintaining simplicity and low cost (Alternatives A and B).</li><li data-list-item-id="e4652bd7b56a456f359a2781093fd2efd">Extend the panel to bioindicators of vitamins B9 and B12&nbsp;by introducing novel binding molecules (Alternatives A and B).</li><li data-list-item-id="ec85570c6f740e8ac601eb32c1d08e258">Measure the nutritional status of vitamins B1 and B2&nbsp;using metabolites or proteins associated with their deficiency (Alternative B).</li><li data-list-item-id="e1a1592a1c8ce58c2fff4f6de0bc70dd1">Develop an immunological or other binding-based test for total folate in red blood cells that gives results comparable to the microbiological assay, and maintain accuracy and precision from small plasma/serum volumes to enable later application to dried blood spots (Alternative B).</li><li data-list-item-id="e3e04f0075fbbcfcb9073c1cf0372b2ff">Maintain accuracy and precision using small plasma or serum volumes in order to enable later application to dried blood spots.</li></ul>Funding LevelAwards depend on the alternative proposed:<ul><li data-list-item-id="e9a580cd00d5973c818a40fc1871d23e3">Alternative A (minimum scope):&nbsp;awards up to US$200,000 per project, with a grant term of up to 12 months.</li><li data-list-item-id="e86361caceef84a8f992cd2c339a50751">Alternative B (optimistic scope):&nbsp;awards up to US$800,000 per project, with a grant term of up to 24 months, evaluated per project.</li></ul>Application budgets should be commensurate with the scope of work proposed. Indirect costs may be included in the budget, up to a maximum of 15% of the total budget (subject to the&nbsp;<a href="https://docs.gatesfoundation.org/Documents/Indirect_Cost_Policy.pdf" target="_blank" title="https://docs.gatesfoundation.org/documents/indirect_cost_policy.pdf">Gates Foundation's indirect cost policy</a>).Eligibility CriteriaThis initiative is open to nonprofit organizations, for-profit companies, international organizations, government agencies and academic institutions. We particularly encourage applications led by women or in collaboration with women-led organizations, and applications from or in collaboration with institutions based in low- and middle-income countries. Only applicants applying through a legally recognized corporate entity are eligible. Because no single institution is likely to hold all the necessary expertise, collaboration among groups working in human metabolism, biomolecule characterization and immunology is strongly encouraged.We are looking for proposals that:<ul><li data-list-item-id="e31e4ae110579e371bf9dd1b98d7a9f3a">Address a clearly defined analyte, performance or cost target within the scope of this challenge.</li><li data-list-item-id="ef490a4802de4777b0f37a2e8babc26ce">Demonstrate a novel or innovative approach to extending multiplex analytical coverage (e.g. new analyte-binding molecules).</li><li data-list-item-id="ea182f134906554a5d5e40f5941be8ee2">Demonstrate collaboration and coordination among institutions with complementary expertise.</li><li data-list-item-id="ea48951bdaa5f88326caa97dc64a2d8d7">Can realistically achieve the objectives within the proposed timeframe.</li><li data-list-item-id="eecb468964a18246a49485342986627fb">Include a feasible implementation plan for low- and middle-income reference laboratories, with attention to affordability and end-user needs.</li><li data-list-item-id="e0d8b96e6a12025d1d650ab86f9454351">Show potential for scalability at low cost and assure the future supply of equipment and reagents.</li><li data-list-item-id="ea15fe930ff1d56c8b6e94bf709a06531">Offer ongoing technical assistance and equipment maintenance.</li></ul>We will not fund proposals that:<ul><li data-list-item-id="e70c2364c722d94b53669e242cf2d8a26">Fall outside the thematic focus of this RFP.</li><li data-list-item-id="e5f1135f2ca25f8a173c0be926958783d">Offer incremental improvements without meaningful innovation.</li><li data-list-item-id="ed8c2d3179849764add43dcb7827daebe">Are commercialization-only efforts.</li><li data-list-item-id="e67ae49490f6bde003e542ba94f16e680">Constitute basic research without translational relevance.</li><li data-list-item-id="eec1cc1ca51b96e799beaff536cb21081">Focus on excluded geographies or populations.</li></ul>

Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease

Before applying to this Grand Challenges request for proposals (RFP), applicants should familiarize themselves with the supporting documents, including the&nbsp;<a href="https://docs.gatesfoundation.org/documents/sample-terms-and-conditions.pdf" target="_blank" rel="noopener noreferrer">terms and conditions of the Gates Foundation</a>, the&nbsp;<a href="https://gcgh.grandchallenges.org/sites/default/files/files/indicators_of_micronutrient_status_rules_and_guidelines.pdf" target="_blank" rel="noopener noreferrer">Rules and Guidelines</a>,&nbsp;<a href="https://gcgh.grandchallenges.org/sites/default/files/files/indicators_of_micronutrient_status_application_instructions.pdf" target="_blank" rel="noopener noreferrer">Application Instructions</a>, and&nbsp;<a href="https://gcgh.grandchallenges.org/sites/default/files/files/indicators_of_micronutrient_status_faqs.pdf" target="_blank" rel="noopener noreferrer">Frequently Asked Questions (FAQs)</a>.
If you plan to apply to this RFP, we will host a dedicated&nbsp;<a href="https://events.teams.microsoft.com/event/87a5ecee-9e3c-417d-a46c-ab3012b9fa85@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank" rel="noopener noreferrer">webinar</a>&nbsp;on August 11, 2026, 7:00-8:00 a.m. US PDT. The session will provide an overview of the RFP and include time for questions. To attend, please <a href="https://events.teams.microsoft.com/event/87a5ecee-9e3c-417d-a46c-ab3012b9fa85@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank" rel="noopener noreferrer">register</a> and&nbsp;<a href="https://forms.cloud.microsoft/Pages/ResponsePage.aspx?id=ODhrKdVLbEm9S_RW6nQ7dNyUf4PhutFBmFMAT6JKpddUOVBQVzFaR041MFc4MEU0QkFDTEpUVEs1Qi4u" target="_blank" rel="noopener noreferrer">submit your questions in advance</a>. A recording will be posted on the challenge page following the session for those unable to join live.
<h2>Background</h2>
Vitamins and minerals, collectively referred to as micronutrients), play essential roles in human metabolism and are required for physical growth, cognitive development, immune function, and the recovery from infection. Micronutrient deficiencies, particularly among vulnerable groups in low- and middle-income countries (chiefly women of child-bearing age, especially during pregnancy and lactation, preschool-age children and older adults), constrain social and economic development and limit progress toward good health and well-being. These deficiencies may arise from insufficient dietary intake, from concurrent disease or parasitism, or from genetic traits that affect MN metabolism. Diagnosing their causes, magnitude, severity, and population prevalence is essential for designing appropriate treatments and interventions, and for monitoring their effectiveness and safety.
Over the past fifty years, progress against several long-standing micronutrient deficiencies has been substantial. Goiter and cognitive impairment caused by iodine deficiency have largely disappeared with iodized salt and iodine supplementation in animal feed; survival and resistance to infection have improved through correction of vitamin A deficiency; and neural tube defects have fallen in many high-income countries through folic acid fortification and supplementation. Progress against iron deficiency and anemia has been more modest, in part because infection and inflammation impair iron absorption and utilization. Micronutrient status must therefore be assessed together with biomarkers of infection and inflammation. There is also a need to add bioindicators for micronutrients that are infrequently assessed but central to physiology: vitamins B2 and B12, for example, are essential for the conversion of folic acid into folate (the active form of vitamin B9) and for combined action as catalyzers of many enzymatic reactions. In non-affluent populations, B2 or B12 deficiency may be as important as B9 deficiency.
Recent advances in immunological and molecular recognition technologies allow several bioindicators to be measured simultaneously. For example, the Quansys multiplex kit measures several analytes (soluble transferrin receptor, ferritin, retinol binding protein, thyroglobulin and the acute-phase proteins CRP and AGP) in a single microplate well. This is possible because these analytes are immunogenic proteins for which specific antibodies can be generated. Extending this approach to less immunogenic bioindicators may now be feasible using other analyte-binding molecules, such as folate-binding protein from milk or porcine plasma, the B12 intrinsic factor, and synthetic nucleotide sequences, including RNA or DNA) aptamers that bind small molecules. This Grand Challenge seeks novel approaches to extend analytical coverage, improve sensitivity and specificity, simplify measurement, reduce cost, and enable frequent monitoring of micronutrient status by local institutions. A multiplex assay works only for analytes of similar chemical nature and concentration, so the wider micronutrient panel under discussion for the MNBI (for example zinc, vitamin C and vitamin D) cannot simply be folded into a single platform; those analytes require different detection principles and belong to separate future workstreams. No single platform is expected to carry every analyte, and this challenge focuses on the multiplex-compatible set, allowing a complementary, separate plate where needed (for example, red-blood-cell folate).
<h2>The Challenge</h2>
Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of&nbsp;analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would&nbsp;also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).
The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations&nbsp;(women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.
This challenge is structured around two alternatives,&nbsp;a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate <a href="https://gcgh.grandchallenges.org/sites/default/files/files/indicators_of_micronutrient_status_target_product_profile.pdf" target="_blank" rel="noopener noreferrer">Target Product Profile</a> for this platform, and applicants will be held to the relevant performance, cost and instrument targets.
<div class="responsive-table"><table>
<thead>
<tr>
<th>Parameter</th>
<th>Alternative A - Minimum scope</th>
<th>Alternative B - Optimistic scope</th>
</tr>
</thead>
<tbody>
<tr>
<td>Analyte panel</td>
<td>Strengthen and modestly extend the current multiplex test. Measure: soluble transferrin receptor, ferritin, RBP4, thyroglobulin, plasma methyl-tetrahydrofolate (without cross-reactivity with folic acid; a complementary folic-acid-specific test may be proposed), holo-transcobalamin (without cross-reactivity with apo-transcobalamin and all-haptocorrin), CRP and AGP.</td>
<td>All Alternative A analytes, plus metabolites or proteins associated with vitamin B1 and B2 deficiency, and thyroid hormones. A complementary test for whole-folate vitamers in red blood cells may also be included, on a separate microtiter platform if needed.</td>
</tr>
<tr>
<td>Sample volume</td>
<td>≤10 µL plasma/serum</td>
<td>≤5 µL plasma/serum. Other specimen types, such as dried blood spots (DBS), may also be addressed as optimistic scope; see note below. Response (not optimization) in twice that volume of whole blood from the same individuals should also be measured and reported, together with hematocrit.</td>
</tr>
<tr>
<td>Analytical Precision (CV)</td>
<td>&lt;20% CV total; &lt;15% within-run at the functional analytical sensitivity covering the expected physiological range of each analyte</td>
<td>&lt;10% CV total; &lt;8% within-run at the functional analytical sensitivity covering the expected physiological range of each analyte</td>
</tr>
<tr>
<td>Analytical sensitivity (LoD)</td>
<td>sTfR: 2–30 mg/L&nbsp; Ferritin: 5–100 µg/L&nbsp; RBP4: 0.3–3.0 µmol/L&nbsp; Thyroglobulin: 10–100 µg/L&nbsp; Methyl-THF: 5–50 nmol/L&nbsp; Holo-transcobalamin: to be defined&nbsp; CRP: 1–30 mg/L&nbsp; AGP: 0.5–5 g/L&nbsp; &nbsp;&nbsp; &nbsp;&nbsp; &nbsp;</td>
<td>sTfR: 1–40 mg/L&nbsp; Ferritin: 2–200 µg/L&nbsp; RBP4: 0.2–4.0 µmol/L&nbsp; Thyroglobulin: 5–300 µg/L&nbsp; Methyl-THF: 2–100 nmol/L&nbsp; RBC folate: 100–2000 nmol/L&nbsp; Holo-transcobalamin: to be defined&nbsp; CRP: 1–50 mg/L&nbsp; AGP: 0.25–5 g/L&nbsp; Thyroid hormones, B1, B2: as required for satisfactory diagnostic performance</td>
</tr>
<tr>
<td>Accuracy (Bias / Trueness)</td>
<td>≤ 10% bias across the measuring range for all target analytes when tested against certified reference materials</td>
<td>≤ 5% bias across the measuring range for all target analytes when tested against certified reference materials</td>
</tr>
<tr>
<td>Concordance&nbsp;</td>
<td>≥90% concordance when measured against, validated laboratory immunoassays or analytical gold standard methods, for all target analytes</td>
<td>≥95% concordance when measured against, validated laboratory immunoassays or analytical gold standard methods, for all target analytes</td>
</tr>
<tr>
<td>Cost target</td>
<td>≤US$20 per sample for all analytes measured in duplicate (i.e., 2 wells). This ceiling is per sample for the full panel in duplicate, not per analyte.</td>
<td>≤US$20 per sample for all analytes measured in duplicate (i.e., 2 wells). Optimistic stretch goal: ≤US$10 per sample for the full panel in duplicate.</td>
</tr>
<tr>
<td>Instrument</td>
<td>Bench-top signal-detection device, ≤US$30,000 per unit.</td>
<td>Bench-top signal-detection device, ≤US$25,000 per unit.</td>
</tr>
<tr>
<td>Funding &amp; term</td>
<td>Awards up to US$200,000 per project; grant term up to 12 months.</td>
<td>Awards up to US$800,000 per project; grant term up to 24 months. Budgets and terms evaluated per project and commensurate with scope.</td>
</tr>
</tbody>
</table></div>
Note on dried blood spots:&nbsp;application of these assays to dried blood spots is a distinct downstream study to be undertaken once the tests are developed, and is not part of the core development scope of either alternative. Sample-volume targets are included&nbsp;to keep this pathway open. Applicants with an integrated, DBS-capable approach may optionally submit DBS-readiness data; such data are invited but will not be scored.
Specifically, the objectives of this challenge are to:
<ul>
<li>Improve the current multiplex test for immunological determination of nutritional-status analytes, overcoming standard heterogeneity, widening the functional analytical range to the expected physiological values, and maintaining simplicity and low cost (Alternatives A and B).</li>
<li>Extend the panel to bioindicators of vitamins B9 and B12&nbsp;by introducing novel binding molecules (Alternatives A and B).</li>
<li>Measure the nutritional status of vitamins B1 and B2&nbsp;using metabolites or proteins associated with their deficiency (Alternative B).</li>
<li>Develop an immunological or other binding-based test for total folate in red blood cells that gives results comparable to the microbiological assay, and maintain accuracy and precision from small plasma/serum volumes to enable later application to dried blood spots (Alternative B).</li>
<li>Maintain accuracy and precision using small plasma or serum volumes in order to enable later application to dried blood spots.</li>
</ul>
Funding Level
Awards depend on the alternative proposed:
<ul>
<li>Alternative A (minimum scope):&nbsp;awards up to US$200,000 per project, with a grant term of up to 12 months.</li>
<li>Alternative B (optimistic scope):&nbsp;awards up to US$800,000 per project, with a grant term of up to 24 months, evaluated per project.</li>
</ul>
Application budgets should be commensurate with the scope of work proposed. Indirect costs may be included in the budget, up to a maximum of 15% of the total budget (subject to the&nbsp;<a href="https://docs.gatesfoundation.org/Documents/Indirect_Cost_Policy.pdf" target="_blank" title="https://docs.gatesfoundation.org/documents/indirect_cost_policy.pdf" rel="noopener noreferrer">Gates Foundation's indirect cost policy</a>).
Eligibility Criteria
This initiative is open to nonprofit organizations, for-profit companies, international organizations, government agencies and academic institutions. We particularly encourage applications led by women or in collaboration with women-led organizations, and applications from or in collaboration with institutions based in low- and middle-income countries. Only applicants applying through a legally recognized corporate entity are eligible. Because no single institution is likely to hold all the necessary expertise, collaboration among groups working in human metabolism, biomolecule characterization and immunology is strongly encouraged.
We are looking for proposals that:
<ul>
<li>Address a clearly defined analyte, performance or cost target within the scope of this challenge.</li>
<li>Demonstrate a novel or innovative approach to extending multiplex analytical coverage (e.g. new analyte-binding molecules).</li>
<li>Demonstrate collaboration and coordination among institutions with complementary expertise.</li>
<li>Can realistically achieve the objectives within the proposed timeframe.</li>
<li>Include a feasible implementation plan for low- and middle-income reference laboratories, with attention to affordability and end-user needs.</li>
<li>Show potential for scalability at low cost and assure the future supply of equipment and reagents.</li>
<li>Offer ongoing technical assistance and equipment maintenance.</li>
</ul>
We will not fund proposals that:
<ul>
<li>Fall outside the thematic focus of this RFP.</li>
<li>Offer incremental improvements without meaningful innovation.</li>
<li>Are commercialization-only efforts.</li>
<li>Constitute basic research without translational relevance.</li>
<li>Focus on excluded geographies or populations.</li>
</ul>

Micronutrient deficiencies, particularly among vulnerable groups in low- and middle-income countries (chiefly women of child-bearing age, especially during pregnancy and lactation, preschool-age children and older adults), constrain social and economic development and limit progress toward good health and well-being. These deficiencies may arise from insufficient dietary intake, from concurrent disease or parasitism, or from genetic traits that affect MN metabolism. Diagnosing their causes, magnitude, severity, and population prevalence is essential for designing appropriate treatments and interventions, and for monitoring their effectiveness and safety.

Multiplex Platforms to Assess Indicators of Micronutrient Status Inflammation and Infectious Disease

Innovations in Decentralized Pan-Orthoebolavirus Diagnostics

This Grand Challenge seeks specific, field-ready innovations in pan-Orthoebolavirus diagnostics that address the concrete gaps exposed by the 2026 outbreak and prepare the global community for the next one. We are seeking well-defined solutions to well-defined problems, from teams with the specific expertise, access, and partnerships to deliver them.

Innovations in Decentralized Pan-Orthoebolavirus Diagnostics

**NOTE: This opportunity was open only to participants who registered for the 2026 Grand Challenges Annual Meeting.Before applying to this Grand Challenges request for proposals (RFP), applicants should familiarize themselves with the supporting documents, including the&nbsp;<a href="https://docs.gatesfoundation.org/documents/sample-terms-and-conditions.pdf" target="_blank">terms and conditions of the Gates Foundation</a>, the&nbsp;<a href="https://gcgh.grandchallenges.org/sites/default/files/files/gcam_2026_cta_rules_and_guidelines.pdf" target="_blank">Rules and Guidelines</a>,&nbsp;<a href="https://gcgh.grandchallenges.org/sites/default/files/files/gcam_2026_cta_application_instructions.pdf" target="_blank">Application Instructions</a>, and&nbsp;<a href="https://gcgh.grandchallenges.org/sites/default/files/files/gcam_2026_cta_faqs.pdf" target="_blank">Frequently Asked Questions</a>.<h2>The Opportunity</h2>The Grand Challenges Annual Meeting (GCAM) fosters innovation and international collaboration to address the biggest challenges in global health and development. It has been held in&nbsp;<a href="https://grandchallenges.org/annual-meeting" target="_blank">13 countries</a>&nbsp;over the past 21 years and in a virtual format for three years. The 2026 meeting continues the Annual Meeting's goal of supporting a global community of problem solvers who work together to set an innovation agenda and advance breakthrough science – to go further and faster together.<h2>The Challenge</h2>This Call-to-Action provides an opportunity for those registered for the 2026 GCAM to take action based on ideas they develop and people they engage with during the meeting. As noted by past applicants in their submitted proposals, the meeting provides diverse opportunities to combine expertise and perspectives to accelerate the impact of what would otherwise be separate efforts by individual investigators. The&nbsp;<a href="https://gcgh.grandchallenges.org/grants/JTdCJTIyc29ydCUyMiUzQSUyMmRlc2NlbmRpbmclMjIlMkMlMjJzb3J0RmllbGQlMjIlM0ElMjJkYXRlJTIyJTJDJTIybnVtYmVyUGVyUGFnZSUyMiUzQTEwMCUyQyUyMnBhZ2VOdW1iZXIlMjIlM0EwJTdE/JTdCJTIyeWVhcnMlMjIlM0ElNUIlNUQlMkMlMjJjaGFsbGVuZ2VzJTIyJTNBJTVCJTIyMTI5JTIyJTVEJTJDJTIydGVybXMlMjIlM0ElNUIlNUQlMkMlMjJpbml0aWF0aXZlcyUyMiUzQSU1QiU1RCUyQyUyMmxvY2F0aW9ucyUyMiUzQSU1QiU1RCU3RA==" target="_blank">grants awarded</a>&nbsp;for past Call-to-Action opportunities show this, and we hope this year’s meeting will similarly catalyze collaborative projects that yield tangible solutions to key problems by the end of the grant period.FundingWe will consider proposals for awards of up to $100,000 USD for individual pilot projects, or $200,000 for collaborative pilot projects, with a grant term of 18 months. Proposed budgets should be commensurate with the scale and complexity of the work. Indirect costs are allowable and must be included within the total requested funding, in accordance with the Gates Foundation’s&nbsp;<a href="https://docs.gatesfoundation.org/documents/indirect_cost_policy.pdf" target="_blank">indirect cost policy</a>).Eligibility Criteria<ul><li data-list-item-id="e57008f9a5689eabb19d590946780bc75">Participants registered for the 2026 GCAM may submit one application as the Primary Applicant on behalf of an eligible affiliated organization for either a Pilot project or a Collaborative pilot project. Participants may serve as collaborators on multiple applications.</li><li data-list-item-id="e51a29de320e8f0bb53595662040e1e7d">Collaborative pilot proposals must involve participants from multiple institutions, and all collaborators must be registered participants in the 2026 GCAM. Priority will be given to new or newly expanded collaborations.</li><li data-list-item-id="e4dcfaffd9882b172ee962997e423711a">Applications are welcome from nonprofit organizations, for-profit companies, international organizations, government agencies, and academic institutions.</li><li data-list-item-id="e2e7166db7b420888484ef304128dc6e1">Individuals, as well as organizations classified as individuals for U.S. tax purposes, are not eligible to receive funding under this initiative.</li><li data-list-item-id="e0696b69a0802c03ba0d75ec716e0c734">We encourage proposals led by investigators based in low- and middle-income countries, as well as proposals led by women investigators and women-led institutions.</li></ul>We will give highest priority to proposals that:<ul><li data-list-item-id="ed3afd274e6da02fce9a93673c600516f">Contribute to partnership networks that elevate local perspectives and leadership, including projects led by investigators from low- and middle-income countries and balanced representation of women principal investigators.&nbsp;</li><li data-list-item-id="ebe01d53e5685584ed14067efab462e82">Are explicitly aligned with one eligible scientific track and the specific content presented within that track (see&nbsp;<a href="https://web.cvent.com/event/c1e08f5c-af38-4797-82a6-cc410245f1cb/websitePage:a65b32b2-0bf9-4476-8fb9-0761a872a471" target="_blank">meeting agenda</a>).&nbsp;</li><li data-list-item-id="e0ec597c8a36c0cb75b5065ac4f1c6e1c">Proposals should reflect ideas and collaborations developed through participation in the track sessions. Eligible scientific tracks for this RFP are listed below.</li></ul>Scientific tracks eligible for the Grand Challenges Annual Meeting Call-to-Action<ul><li class="ck-list-marker-italic" data-list-item-id="e8f54ec4bb39d09c0ba715ad6934ef850">Malaria: Innovation for Eradication</li><li class="ck-list-marker-italic" data-list-item-id="e1edce52c35432b2eeade698a42300bef">Next Generation Vaccines, Biologics and Platform Technologies to Accelerate Malaria Eradication</li><li class="ck-list-marker-italic" data-list-item-id="e18c561b45b47316f648da073cf5961f6">Dual Mission: Science Now + Ecosystems for the Future</li><li class="ck-list-marker-italic" data-list-item-id="e559edd647633131af8c1bcaac3c656a1">Evidence and Innovation for Impact in Women’s Health and Fetal Well-Being</li></ul>We will not consider funding approaches that:<ul><li data-list-item-id="eac2243f78dbecb774d23df3bc9c2dd67">Are not explicitly aligned with the content of one of the eligible meeting scientific tracks listed above.</li></ul>

2026 Grand Challenges Annual Meeting Call-to-Action

**NOTE: This opportunity is open only to participants who registered for the 2026 Grand Challenges Annual Meeting.
Before applying to this Grand Challenges request for proposals (RFP), applicants should familiarize themselves with the supporting documents, including the&nbsp;<a href="https://docs.gatesfoundation.org/documents/sample-terms-and-conditions.pdf" target="_blank" rel="noopener noreferrer">terms and conditions of the Gates Foundation</a>, the&nbsp;<a href="https://gcgh.grandchallenges.org/sites/default/files/files/gcam_2026_cta_rules_and_guidelines.pdf" target="_blank" rel="noopener noreferrer">Rules and Guidelines</a>,&nbsp;<a href="https://gcgh.grandchallenges.org/sites/default/files/files/gcam_2026_cta_application_instructions.pdf" target="_blank" rel="noopener noreferrer">Application Instructions</a>, and&nbsp;<a href="https://gcgh.grandchallenges.org/2026-grand-challenges-annual-meeting-call-action-frequently-asked-questions-faqs" target="_blank" rel="noopener noreferrer">Frequently Asked Questions</a>.
<h2>The Opportunity</h2>
The Grand Challenges Annual Meeting (GCAM) fosters innovation and international collaboration to address the biggest challenges in global health and development. It has been held in&nbsp;<a href="https://grandchallenges.org/annual-meeting" target="_blank" rel="noopener noreferrer">13 countries</a>&nbsp;over the past 21 years and in a virtual format for three years. The 2026 meeting continues the Annual Meeting's goal of supporting a global community of problem solvers who work together to set an innovation agenda and advance breakthrough science – to go further and faster together.
<h2>The Challenge</h2>
This Call-to-Action provides an opportunity for those registered for the 2026 GCAM to take action based on ideas they develop and people they engage with during the meeting. As noted by past applicants in their submitted proposals, the meeting provides diverse opportunities to combine expertise and perspectives to accelerate the impact of what would otherwise be separate efforts by individual investigators. The&nbsp;<a href="https://gcgh.grandchallenges.org/grants/JTdCJTIyc29ydCUyMiUzQSUyMmRlc2NlbmRpbmclMjIlMkMlMjJzb3J0RmllbGQlMjIlM0ElMjJkYXRlJTIyJTJDJTIybnVtYmVyUGVyUGFnZSUyMiUzQTEwMCUyQyUyMnBhZ2VOdW1iZXIlMjIlM0EwJTdE/JTdCJTIyeWVhcnMlMjIlM0ElNUIlNUQlMkMlMjJjaGFsbGVuZ2VzJTIyJTNBJTVCJTIyMTI5JTIyJTVEJTJDJTIydGVybXMlMjIlM0ElNUIlNUQlMkMlMjJpbml0aWF0aXZlcyUyMiUzQSU1QiU1RCUyQyUyMmxvY2F0aW9ucyUyMiUzQSU1QiU1RCU3RA==" target="_blank" rel="noopener noreferrer">grants awarded</a>&nbsp;for past Call-to-Action opportunities show this, and we hope this year’s meeting will similarly catalyze collaborative projects that yield tangible solutions to key problems by the end of the grant period.
Funding
We will consider proposals for awards of up to $100,000 USD for individual pilot projects, or $200,000 for collaborative pilot projects, with a grant term of 18 months. Proposed budgets should be commensurate with the scale and complexity of the work. Indirect costs are allowable and must be included within the total requested funding, in accordance with the Gates Foundation’s&nbsp;<a href="https://docs.gatesfoundation.org/documents/indirect_cost_policy.pdf" target="_blank" rel="noopener noreferrer">indirect cost policy</a>).
Eligibility Criteria
<ul>
<li>Participants registered for the 2026 GCAM may submit one application as the Primary Applicant on behalf of an eligible affiliated organization for either a Pilot project or a Collaborative pilot project. Participants may serve as collaborators on multiple applications.</li>
<li>Collaborative pilot proposals must involve participants from multiple institutions, and all collaborators must be registered participants in the 2026 GCAM. Priority will be given to new or newly expanded collaborations.</li>
<li>Applications are welcome from nonprofit organizations, for-profit companies, international organizations, government agencies, and academic institutions.</li>
<li>Individuals, as well as organizations classified as individuals for U.S. tax purposes, are not eligible to receive funding under this initiative.</li>
<li>We encourage proposals led by investigators based in low- and middle-income countries, as well as proposals led by women investigators and women-led institutions.</li>
</ul>
We will give highest priority to proposals that:
<ul>
<li>Contribute to partnership networks that elevate local perspectives and leadership, including projects led by investigators from low- and middle-income countries and balanced representation of women principal investigators.&nbsp;</li>
<li>Are explicitly aligned with one eligible scientific track and the specific content presented within that track (see&nbsp;<a href="https://web.cvent.com/event/c1e08f5c-af38-4797-82a6-cc410245f1cb/websitePage:a65b32b2-0bf9-4476-8fb9-0761a872a471" target="_blank" rel="noopener noreferrer">meeting agenda</a>).&nbsp;</li>
<li>Proposals should reflect ideas and collaborations developed through participation in the track sessions. Eligible scientific tracks for this RFP are listed below.</li>
</ul>
Scientific tracks eligible for the Grand Challenges Annual Meeting Call-to-Action
<ul>
<li>Malaria: Innovation for Eradication</li>
<li>Next Generation Vaccines, Biologics and Platform Technologies to Accelerate Malaria Eradication</li>
<li>Dual Mission: Science Now + Ecosystems for the Future</li>
<li>Evidence and Innovation for Impact in Women’s Health and Fetal Well-Being</li>
</ul>
We will not consider funding approaches that:
<ul>
<li>Are not explicitly aligned with the content of one of the eligible meeting scientific tracks listed above.</li>
</ul>

This Call-to-Action provides an opportunity for those registered for the 2025 Grand Challenges Annual Meeting to take action based on ideas they develop and people they engage with during the virtual meeting.

Notice: Applicants will be informed of the decision regarding their project proposals by the end of August 2026.Before applying to this Grand Challenges request for proposals (RFP), applicants should familiarize themselves with the supporting documents, including the <a href="https://docs.gatesfoundation.org/documents/sample-terms-and-conditions.pdf" target="_blank">terms and conditions of the Gates Foundation</a>, the <a href="https://gcgh.grandchallenges.org/sites/default/files/files/global_burden_of_diarrheal_diseases_rules_and_guidelines.pdf" target="_blank">Rules and Guidelines</a>, <a href="https://gcgh.grandchallenges.org/sites/default/files/files/global_burden_of_diarrheal_diseases_application_instructions.pdf" target="_blank">Application Instructions</a>, and <a href="https://gcgh.grandchallenges.org/estimating-global-burden-diarrheal-diseases-frequently-asked-questions-faqs" target="_blank">Frequently Asked Questions.</a>If you plan to apply to this RFP, we will host a dedicated <a href="https://events.teams.microsoft.com/event/705ad6ae-3dba-4300-960a-24954b5f9f04@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank">webinar</a> on May 14, 2026, 8:00-9:00 a.m. US PST. The session will provide an overview of the RFP and include time for questions. To attend, please register and <a href="https://forms.office.com/r/DdDppwuAFU" target="_blank">submit your questions in advance</a>. A recording will be posted on the challenge page following the session for those unable to join live.Please note that the webinar has reached full capacity and registration is now closed. A recording will be posted on this page within 24 hours after the event concludes.The Gates Foundation invites proposals to generate independent, policy-relevant estimates of the global burden of diarrheal diseases, with a focus on mortality and morbidity in children under five living in low- and middle-income countries (LMICs).<h2>Background</h2>Reliable burden estimates are essential for prioritizing disease syndromes and pathogens and for guiding investments in prevention, treatment, and product development. However, estimating diarrheal mortality and morbidity and pathogen-specific burden remains challenging because direct mortality and morbidity data are limited in many LMIC settings, etiologic data are uneven and often derived from studies of cases rather than deaths, and attribution methods must reconcile imperfect diagnostics, multiple pathogens, incomplete surveillance, and sparse location-specific evidence. Modelled estimates of global burden of disease can help overcome data sparsity, and multiple independent estimates would be valuable for triangulating estimates of burden and understanding key drivers of differences. Differences across existing estimates may arise from variation in data inputs, mortality envelopes, etiologic attribution methods, model structure, and assumptions.The Foundation seeks to support independent estimation efforts that inform the overall burden of diarrhea and pathogen-specific contributions, clarify key sources of uncertainty, and produce decision-useful estimates for policymakers, researchers, and global health partners.Multiple burden estimates would help inform the relative importance of diarrhea as a cause of mortality and morbidity in children under five and clarify which pathogens are responsible for the largest share of burden.<h2>The Challenge</h2>Through this Grand Challenge, the Foundation seeks to support organizations with strong epidemiologic and quantitative modeling capabilities to produce credible, transparent, and decision-useful estimates of diarrheal disease burden in LMICs.Applicants should propose approaches that can generate a minimum core set of estimates for the year 2025 and, where feasible, build longer-term analytic capacity in LMICs.Scope of WorkProposals must include plans to generate, at minimum:<ul><li data-list-item-id="e59ce878796907152dfcc7db8744bc6ae">Country-specific estimates of total diarrheal mortality burden in children under five.</li><li data-list-item-id="ee55b91df2f18170c107e6cf8ec9a14e3">Country-specific pathogen-attributed mortality burden for children under five.</li><li data-list-item-id="e6576d2d8fd4a798889d593a40830e899">Estimates reported as both total number of diarrhea-attributed deaths, pathogen-specific fractions, and mortality incidence rates, centered on 2025, using the most recent available data and appropriate methods for projection, interpolation, or extrapolation where needed.</li><li data-list-item-id="e85981683ad46ae75e3651c1a546d0f0e">When possible, country-specific estimates of total and/or pathogen-attributed morbidity burden, measured as all cause or pathogen-specific disease cases, severe disease cases, or hospitalizations and presented as the total numbers, pathogen-specific fractions, and/or incidence rates.</li><li data-list-item-id="e778fdcc2adcc8d939243468925fce0e0">Estimates reported as point estimates with confidence/uncertainty intervals.</li><li data-list-item-id="ebd6420a90b76726e46252ebec4a653bd">Geographic scope: may include proposed estimates for a single country, region, all LMICs, or global. While proposals may focus on a single country, region, all LMICs, or global estimates, preference will be given to proposals focused on geographies where diarrheal mortality is expected to be highest or where improved estimates of both mortality and morbidity would have particularly high programmatic relevance, including but not limited to India, Nigeria, and sub-Saharan Africa.</li></ul>We will consider fully independent modeling frameworks or partial re-estimation based on existing burden estimates and using alternative assumptions or datasets. Proposals must provide sufficient technical documentation for external review and should include planned approaches for etiologic attribution of both disease cases and deaths, including plans for adjudicating coinfections / multiple pathogens detected, at a minimum.At minimum, proposals should include estimates for the following pathogens:<ul><li data-list-item-id="ef913d690fc6d5be9b872a1ee5a6a82fc">Rotavirus</li><li data-list-item-id="ee4e35541c0b0a8b039f4a3e9b88f1a9c">Shigella</li><li data-list-item-id="e062c939e94012b47f81fb114a0ad30e3">Adenovirus 40/41</li><li data-list-item-id="e0a6d43d3105a57fcffd486048cd867fc">Norovirus GII</li><li data-list-item-id="e667158388ee2879e3eaa9bc7b0d5c285">ST-ETEC</li><li data-list-item-id="ea2dd162fb27bc10146616ea9f04e10fd">Cholera (endemic)</li><li data-list-item-id="e4af640003b6c76ebd5e8dbe93cc09d20">Cryptosporidium</li><li data-list-item-id="e3d00f0285c5f24ae9d899c245dbf096f">Campylobacter</li></ul>Applicants may also propose additional analyses beyond the minimum required set, such as:<ul><li data-list-item-id="e8ad3ca56cc2f505a9b0fc740cda65f39">Expansion to broader age groups</li><li data-list-item-id="eb4d1315975d5bdf3422e6bc56d58ee47">Expansion to additional diarrhea etiologies</li><li data-list-item-id="e34bd9e0a0434bf02e8b93b142eb9ddc9">Additional burden outputs, including DALYs or costs</li><li data-list-item-id="e56723d174697f4e51aceca20e77edaf0">Historical trend analyses</li><li data-list-item-id="ec3a273eacd0923d644d1391710cff010">Regional or global geographic aggregation</li></ul>However, all proposals must clearly deliver the minimum required output set above.Applicants should recognize that this opportunity is intended not only to produce burden estimates, but also to improve confidence in the evidence base used for priority setting. We are seeking outputs that can inform syndrome and pathogen prioritization and that are interpretable by global and country decision-makers. Proposals should therefore address how resulting estimates will be interpreted, compared with existing approaches, and made useful to stakeholders. There should also be clear communication of uncertainty and sensitivity to assumptions.What we are looking for:The Foundation is particularly interested in proposals that demonstrate:<ul><li data-list-item-id="e37189ccc85c6b2fc2e88c7186f0c9d26">Scientific rigor and methodological transparency</li><li data-list-item-id="eada5128925807ad8411a99d7bbe875d8">Credible alternatives or complements to existing estimates (e.g. IHME Global Burden of Disease)</li><li data-list-item-id="e4d1d84685a6ffbb7f281fa76bfdb2ef6">Strong use of available epidemiologic, surveillance, and etiologic data</li><li data-list-item-id="e9bbe7fb635d2e9148c28960b045c9007">Clear assumptions and sensitivity analyses</li><li data-list-item-id="e0cd83887db274187a67cf701fdb2cf0f">Practical relevance for decision-makers in global health and child survival</li><li data-list-item-id="e4129ff85f3df521a7121ffb5b9bb4540">Potential to strengthen analytic and modeling capacity in LMIC institutions or partnerships</li></ul>We will not fund proposals that:<ul><li data-list-item-id="e5fa12a3ea4a96b672ccc82f4cd1e5784">Do not focus on diarrheal burden estimation</li><li data-list-item-id="e875aa76f84644197017165805f575510">Do not include mortality estimates for children under five</li><li data-list-item-id="e14ac053261b187c031b45ffa2147e0e6">Do not provide a clear methodological approach for pathogen attribution</li><li data-list-item-id="ee8c3735f3f41009cbfc02c70239e0e78">Rely primarily on literature review without a substantive analytic plan</li><li data-list-item-id="ea2175241bd18ce3cd0d1c13aede36035">Do not specify underlying data sources and handling of uncertainty</li><li data-list-item-id="ea44318b1c25a083d37d15c33bf213ca1">Are intervention studies or surveillance implementation</li><li data-list-item-id="e97a900ea2f802faa763b563f8f229d30">Do not clearly explain how outputs will improve on, complement, or interrogate existing burden estimates</li><li data-list-item-id="e557cb167778bf212059dfa38f4cf6f4c">Are not submitted by an LMIC-based institution, led by an LMIC institution in partnership, or part of a global consortium with meaningful LMIC partner engagement&nbsp;</li><li data-list-item-id="e69d4d710bab4fc406de45b5f8dac7787">Do not explicitly address how they will generate estimates for the minimum required outputs</li></ul>EligibilityThis opportunity is open to research institutes, nonprofit organizations, for-profit companies, international organizations, government agencies, and academic institutions. with demonstrated expertise in disease burden estimation, epidemiology, biostatistics, and related quantitative methods.We welcome proposals from:<ul><li data-list-item-id="ef335880294ce9ba9f69311a83d223915">LMIC-based institutions</li><li data-list-item-id="e7578e97ae8bc7a5cccf4d092a4058f23">Partnerships led by LMIC institutions</li><li data-list-item-id="e0ee151e80f95b6ed3cd74e1d895366e2">Global consortia that include meaningful LMIC partner engagement and capacity development</li></ul>Applications that pair high-quality analytic output with intentional LMIC capacity building are especially encouraged.Funding LevelWe will consider applications requesting up to $1.5 million USD per project, with a maximum grant duration of two years. Proposed budgets should be commensurate with the scale and complexity of the work. Indirect costs are allowable and must be included within the total requested funding, in accordance with the Gates Foundation’s <a href="https://docs.gatesfoundation.org/documents/indirect_cost_policy.pdf" target="_blank">indirect cost policy</a>).

Estimating the Global Burden of Diarrheal Diseases

Before applying to this Grand Challenges request for proposals (RFP), applicants should familiarize themselves with the supporting documents, including the <a href="https://docs.gatesfoundation.org/documents/sample-terms-and-conditions.pdf" target="_blank" rel="noopener noreferrer">terms and conditions of the Gates Foundation</a>, the <a href="https://gcgh.grandchallenges.org/sites/default/files/files/global_burden_of_diarrheal_diseases_rules_and_guidelines.pdf" target="_blank" rel="noopener noreferrer">Rules and Guidelines</a>, <a href="https://gcgh.grandchallenges.org/sites/default/files/files/global_burden_of_diarrheal_diseases_application_instructions.pdf" target="_blank" rel="noopener noreferrer">Application Instructions</a>, and <a href="https://gcgh.grandchallenges.org/estimating-global-burden-diarrheal-diseases-frequently-asked-questions-faqs" target="_blank" rel="noopener noreferrer">Frequently Asked Questions.</a>
If you plan to apply to this RFP, we will host a dedicated <a href="https://events.teams.microsoft.com/event/705ad6ae-3dba-4300-960a-24954b5f9f04@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank" rel="noopener noreferrer">webinar</a> on May 14, 2026, 8:00-9:00 a.m. US PST. The session will provide an overview of the RFP and include time for questions. To attend, please register and <a href="https://forms.office.com/r/DdDppwuAFU" target="_blank" rel="noopener noreferrer">submit your questions in advance</a>. A recording will be posted on the challenge page following the session for those unable to join live.
Please note that the webinar has reached full capacity and registration is now closed. A recording will be posted on this page within 24 hours after the event concludes.
The Gates Foundation invites proposals to generate independent, policy-relevant estimates of the global burden of diarrheal diseases, with a focus on mortality and morbidity in children under five living in low- and middle-income countries (LMICs).
<h2>Background</h2>
Reliable burden estimates are essential for prioritizing disease syndromes and pathogens and for guiding investments in prevention, treatment, and product development. However, estimating diarrheal mortality and morbidity and pathogen-specific burden remains challenging because direct mortality and morbidity data are limited in many LMIC settings, etiologic data are uneven and often derived from studies of cases rather than deaths, and attribution methods must reconcile imperfect diagnostics, multiple pathogens, incomplete surveillance, and sparse location-specific evidence. Modelled estimates of global burden of disease can help overcome data sparsity, and multiple independent estimates would be valuable for triangulating estimates of burden and understanding key drivers of differences. Differences across existing estimates may arise from variation in data inputs, mortality envelopes, etiologic attribution methods, model structure, and assumptions.
The Foundation seeks to support independent estimation efforts that inform the overall burden of diarrhea and pathogen-specific contributions, clarify key sources of uncertainty, and produce decision-useful estimates for policymakers, researchers, and global health partners.
Multiple burden estimates would help inform the relative importance of diarrhea as a cause of mortality and morbidity in children under five and clarify which pathogens are responsible for the largest share of burden.
<h2>The Challenge</h2>
Through this Grand Challenge, the Foundation seeks to support organizations with strong epidemiologic and quantitative modeling capabilities to produce credible, transparent, and decision-useful estimates of diarrheal disease burden in LMICs.
Applicants should propose approaches that can generate a minimum core set of estimates for the year 2025 and, where feasible, build longer-term analytic capacity in LMICs.
Scope of Work
Proposals must include plans to generate, at minimum:
<ul>
<li>Country-specific estimates of total diarrheal mortality burden in children under five.</li>
<li>Country-specific pathogen-attributed mortality burden for children under five.</li>
<li>Estimates reported as both total number of diarrhea-attributed deaths, pathogen-specific fractions, and mortality incidence rates, centered on 2025, using the most recent available data and appropriate methods for projection, interpolation, or extrapolation where needed.</li>
<li>When possible, country-specific estimates of total and/or pathogen-attributed morbidity burden, measured as all cause or pathogen-specific disease cases, severe disease cases, or hospitalizations and presented as the total numbers, pathogen-specific fractions, and/or incidence rates.</li>
<li>Estimates reported as point estimates with confidence/uncertainty intervals.</li>
<li>Geographic scope: may include proposed estimates for a single country, region, all LMICs, or global. While proposals may focus on a single country, region, all LMICs, or global estimates, preference will be given to proposals focused on geographies where diarrheal mortality is expected to be highest or where improved estimates of both mortality and morbidity would have particularly high programmatic relevance, including but not limited to India, Nigeria, and sub-Saharan Africa.</li>
</ul>
We will consider fully independent modeling frameworks or partial re-estimation based on existing burden estimates and using alternative assumptions or datasets. Proposals must provide sufficient technical documentation for external review and should include planned approaches for etiologic attribution of both disease cases and deaths, including plans for adjudicating coinfections / multiple pathogens detected, at a minimum.
At minimum, proposals should include estimates for the following pathogens:
<ul>
<li>Rotavirus</li>
<li>Shigella</li>
<li>Adenovirus 40/41</li>
<li>Norovirus GII</li>
<li>ST-ETEC</li>
<li>Cholera (endemic)</li>
<li>Cryptosporidium</li>
<li>Campylobacter</li>
</ul>
Applicants may also propose additional analyses beyond the minimum required set, such as:
<ul>
<li>Expansion to broader age groups</li>
<li>Expansion to additional diarrhea etiologies</li>
<li>Additional burden outputs, including DALYs or costs</li>
<li>Historical trend analyses</li>
<li>Regional or global geographic aggregation</li>
</ul>
However, all proposals must clearly deliver the minimum required output set above.
Applicants should recognize that this opportunity is intended not only to produce burden estimates, but also to improve confidence in the evidence base used for priority setting. We are seeking outputs that can inform syndrome and pathogen prioritization and that are interpretable by global and country decision-makers. Proposals should therefore address how resulting estimates will be interpreted, compared with existing approaches, and made useful to stakeholders. There should also be clear communication of uncertainty and sensitivity to assumptions.
What we are looking for:
The Foundation is particularly interested in proposals that demonstrate:
<ul>
<li>Scientific rigor and methodological transparency</li>
<li>Credible alternatives or complements to existing estimates (e.g. IHME Global Burden of Disease)</li>
<li>Strong use of available epidemiologic, surveillance, and etiologic data</li>
<li>Clear assumptions and sensitivity analyses</li>
<li>Practical relevance for decision-makers in global health and child survival</li>
<li>Potential to strengthen analytic and modeling capacity in LMIC institutions or partnerships</li>
</ul>
We will not fund proposals that:
<ul>
<li>Do not focus on diarrheal burden estimation</li>
<li>Do not include mortality estimates for children under five</li>
<li>Do not provide a clear methodological approach for pathogen attribution</li>
<li>Rely primarily on literature review without a substantive analytic plan</li>
<li>Do not specify underlying data sources and handling of uncertainty</li>
<li>Are intervention studies or surveillance implementation</li>
<li>Do not clearly explain how outputs will improve on, complement, or interrogate existing burden estimates</li>
<li>Are not submitted by an LMIC-based institution, led by an LMIC institution in partnership, or part of a global consortium with meaningful LMIC partner engagement&nbsp;</li>
<li>Do not explicitly address how they will generate estimates for the minimum required outputs</li>
</ul>
Eligibility
This opportunity is open to research institutes, nonprofit organizations, for-profit companies, international organizations, government agencies, and academic institutions. with demonstrated expertise in disease burden estimation, epidemiology, biostatistics, and related quantitative methods.
We welcome proposals from:
<ul>
<li>LMIC-based institutions</li>
<li>Partnerships led by LMIC institutions</li>
<li>Global consortia that include meaningful LMIC partner engagement and capacity development</li>
</ul>
Applications that pair high-quality analytic output with intentional LMIC capacity building are especially encouraged.
Funding Level
We will consider applications requesting up to $1.5 million USD per project, with a maximum grant duration of two years. Proposed budgets should be commensurate with the scale and complexity of the work. Indirect costs are allowable and must be included within the total requested funding, in accordance with the Gates Foundation’s <a href="https://docs.gatesfoundation.org/documents/indirect_cost_policy.pdf" target="_blank" rel="noopener noreferrer">indirect cost policy</a>).

The Gates Foundation invites proposals to generate independent, policy-relevant estimates of the global burden of diarrheal diseases, with a focus on mortality and morbidity in children under five living in low- and middle-income countries (LMICs).

Establishment of an African Procurement and Supply Chain Observatory for Public Health and R and D Reagents and Laboratory Supplies

**NOTE: Application for this opportunity was by invitation only.

Establishment of an African Procurement and Supply Chain Observatory for Public Health and R&amp;D Reagents and Laboratory Supplies

Notice: Applicants will be informed of the decision regarding their project proposals by the end of August 2026.Before applying to this Grand Challenges request for proposals (RFP), applicants should familiarize themselves with the supporting documents, including the <a href="https://docs.gatesfoundation.org/documents/sample-terms-and-conditions.pdf" target="_blank">terms and conditions of the Gates Foundation</a>, the <a href="https://gcgh.grandchallenges.org/sites/default/files/files/strategies_to_improve_fortification_programs_rules_and_guidelines.pdf" target="_blank">Rules and Guidelines</a>, <a href="https://gcgh.grandchallenges.org/sites/default/files/files/strategies_to_improve_fortification_programs_application_instructions.pdf" target="_blank">Application Instructions</a>, and <a href="https://gcgh.grandchallenges.org/addressing-physiological-barriers-micronutrient-absorption-fortified-foods-frequently-asked" target="_blank">Frequently Asked Questions</a>.If you are planning to apply to this RFP, we will be hosting a dedicated <a href="https://events.teams.microsoft.com/event/56546af0-f206-4898-9303-a5ebfac6e9a7@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank">webinar</a> on April 2, from 8:30-9:30 AM Pacific Time. This session will provide a comprehensive overview of the RFP details and an opportunity to have your questions answered. To participate in the <a href="https://events.teams.microsoft.com/event/56546af0-f206-4898-9303-a5ebfac6e9a7@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank">webinar</a>, please register and <a href="https://forms.office.com/Pages/ResponsePage.aspx?id=ODhrKdVLbEm9S_RW6nQ7dMKiReMZsCJFmCa42S92Da1UNkJHR1BPNkhSMVNDVDUwNEdKRlBQUExRVS4u" target="_blank">submit your questions in advance</a>. If you cannot attend live, the webinar will be recorded and available on this challenge page after the session.<h2>Background</h2>Despite the proven potential of large-scale food fortification to address micronutrient deficiencies, biological constraints may limit its impact in high-burden settings. Chronic inflammation - driven by recurrent infections, environmental enteric dysfunction (EED), poor sanitation, metabolic disorders, or other systemic stressors - can impair intestinal absorption and alter nutrient metabolism. For example, inflammation-induced upregulation of hepcidin reduces iron absorption and mobilization, diminishing the effectiveness of iron fortification even when dietary intake is sufficient. Inflammation and gut barrier dysfunction can also compromise the absorption of other micronutrients, including zinc and fat-soluble vitamins. In parallel, alterations in the gut microbiome may influence micronutrient bioavailability through competitive uptake, reduced endogenous vitamin synthesis, and amplification of mucosal inflammation. These physiological barriers are particularly salient in low-resource contexts where infection and undernutrition co-occur.<h2>The Challenge</h2>We are soliciting, through this Grand Challenges RFP, applications that advance innovative approaches to better understand, measure, and mitigate infection, inflammation- and microbiome-mediated constraints that limit the impact of fortification interventions. The goal is to overcome key biological barriers and unlock the full potential of fortification programs to accelerate equitable gains in nutrition and health. Solutions could include novel biomarkers to identify populations with impaired nutrient utilization, fortificant formulations optimized for inflammatory states, adjunctive strategies to restore gut function, or integrated interventions that address infection, gut health, and micronutrient delivery simultaneously. Addressing these biological barriers is essential to unlocking the full potential of fortification programs and accelerating equitable gains in nutrition and health.The challenge aims to:<ul><li data-list-item-id="ebbf9b74f0f4b3cba5cc790cb97037c82">Identify the physiological parameters that can be modulated to improve micronutrient absorption.</li><li data-list-item-id="e537085a76e843ff964c1a1c9ea14503b">Offer a solution for delivery and effective absorption of micronutrients such as iron in a target population where nutritional interventions have not been effective.</li><li data-list-item-id="e0a78682579355ebea296ee3e5305041b">All stages of development would be accepted provided the potential impact is clearly defined. We will particularly consider new innovative product ideas, proof of concept and discovery of new approaches to achieve more effective fortification. The solution is not limited to a product; it can also be a strategic approach and is open to discovery R&amp;D program proposals to address unanswered scientific questions.&nbsp;</li></ul>Funding LevelWe will consider proposals for awards of up to $250,000 USD for each project, with a grant term of 18 months. Application budgets should be commensurate with the scope of work proposed. Indirect costs will be considered and should be included in the budget for the up to $250,000 USD award (subject to the&nbsp;<a href="https://docs.gatesfoundation.org/Documents/Indirect_Cost_Policy.pdf" target="_blank" title="https://docs.gatesfoundation.org/documents/indirect_cost_policy.pdf">Gates Foundation's indirect cost policy</a>).Eligibility CriteriaThis initiative is open globally to nonprofit organizations, for-profit companies, international organizations, government agencies and academic institutions. Multi stakeholder collaborations are encouraged. Individuals and organizations classified as individuals for U.S. tax purposes are not eligible to receive an award from the foundation as part of this initiative.&nbsp;We are looking for proposals that consider:&nbsp;<ul><li class="ck-list-marker-bold" data-list-item-id="eb607a653256058a11e5a63da8385a14b">Clear framing of the problem:<ul><li data-list-item-id="e3366a9d1df5a73525d287063efd10ef2">Explicit articulation of how inflammation, infection, EED, metabolic conditions, or gut dysbiosis limit micronutrient absorption and utilization.</li><li data-list-item-id="ed397a35dea94b09b29f52c7983383536">Defined target population and context where fortification effectiveness is currently constrained.</li></ul></li><li class="ck-list-marker-bold" data-list-item-id="e437c36f0afae274cec7d87b147c47e2a">Strong biological rationale<ul><li data-list-item-id="e93aedb43adab6d5442b4a7b431435981">Mechanistic understanding (e.g., hepcidin-mediated iron blockade, impaired fat absorption, microbiome–nutrient interactions).</li><li data-list-item-id="ecb11ad7574fca4909a2bed3ef0da573e">Clear linkage between proposed solution and the underlying physiological barrier.</li></ul></li><li class="ck-list-marker-bold" data-list-item-id="ebcd0d9f1d0ddaebeb8ee5f7b62823931">Innovative and testable solution<ul><li data-list-item-id="e5b60ac022d18dd7b4d9ba061f61161bf">Novel fortificant formulations, delivery approaches, or adjunctive therapies.</li><li data-list-item-id="eb4c6bee4cf43c6076db21804332ccb17">Microbiome-modulating, anti-inflammatory, or gut-repair strategies integrated with fortification.</li><li data-list-item-id="e4da126edd4a5e36144d8bd76bff8b761">Development or validation of practical biomarkers to identify or stratify affected populations.</li></ul></li><li class="ck-list-marker-bold" data-list-item-id="ebf9c1de13807d07b2d04aafa5683e719">Feasibility and scalability<ul><li data-list-item-id="eb0c280efafdb4f0d67b38d947239bd14">Practical pathway for integration into existing fortification platforms or delivery systems.</li><li data-list-item-id="e4c5af63cf8e8051dda2c3dbc03ed404d">Cost-effective design appropriate for low-resource settings.</li><li data-list-item-id="e70f405618b685eed86d33b0f5b6c9495">Consideration of regulatory, manufacturing, and supply chain implications.</li></ul></li><li class="ck-list-marker-bold" data-list-item-id="ef7500931145d483bea5f172b9dfac39e">Measurement and evaluation plan<ul><li data-list-item-id="e0b06d6936be0935dd06b3799b8816ecf">Clearly articulated theory of change with appropriate outcomes related to micronutrient absorption, status, and functional impact.</li><li data-list-item-id="eaf272c27b92b4fc2a377f907f01836b5">Inclusion of inflammation and/or gut function biomarkers where appropriate.</li><li data-list-item-id="e365fa60ddd7b8c9eb7ee59ff41192bc3">Rigorous study design with defined milestones and go/no-go criteria.</li></ul></li><li class="ck-list-marker-bold" data-list-item-id="ecbb5622f9b22d1bd967b101add43d81d">Equity and context relevance<ul><li data-list-item-id="e91fbb976e4578f8512ad8b386f289fca">Focus on populations with high burdens of infection, undernutrition, or systemic inflammation.</li><li data-list-item-id="e641012c386e96a42a56d7a6a6948e2df">Engagement with local partners and alignment with national nutrition strategies.</li></ul></li><li class="ck-list-marker-bold" data-list-item-id="ede926e51d60beb775a9377725b94e7c1">Risk assessment and mitigation<ul><li data-list-item-id="e96666468a7f637d0518ef77c68cd0e7e">Consideration of potential unintended consequences (e.g., microbiome disruption, pathogen proliferation, adverse nutrient interactions).</li><li data-list-item-id="ed53301c8ddd0c03ec298020f9e91592d">Defined strategy for mitigating and managing scientific and implementation risks.</li></ul></li><li class="ck-list-marker-bold" data-list-item-id="e6a8478a9c639d21e97eb4da7cbf4a4de">Team capability<ul><li data-list-item-id="e58bf1af0acafcce3be9f4a188b8057ec">Multidisciplinary expertise as required for the topic (nutrition, immunology, microbiome science, implementation science, product development).</li><li data-list-item-id="ebbde30ff10400cab2465b66ac74433bc">Demonstrated ability to translate discovery into scalable impact.</li></ul></li></ul>We will not fund proposals that focus on:<ul><li data-list-item-id="e16700856870d969e4d283470a571aa86">Agricultural and plant biology related topics of research.</li><li data-list-item-id="ea2d99c5397971a3f35d57873a6a617ac">Live biotherapeutics which will encounter regulatory challenges for use in food.</li><li data-list-item-id="e68a8e737a1df43d260580d7c2e872d3d">Public health data collection and population status assessment.</li><li data-list-item-id="effea6f6ce28119adb015095790017187">Policy making and advocacy.</li><li data-list-item-id="e6a034f23e8089cdb84c34e611da4f150">Commercialization and marketing solely.</li></ul>

Addressing Physiological Barriers to Micronutrient Absorption from Fortified Foods

Before applying to this Grand Challenges request for proposals (RFP), applicants should familiarize themselves with the supporting documents, including the <a href="https://docs.gatesfoundation.org/documents/sample-terms-and-conditions.pdf" target="_blank" rel="noopener noreferrer">terms and conditions of the Gates Foundation</a>, the <a href="https://gcgh.grandchallenges.org/sites/default/files/files/strategies_to_improve_fortification_programs_rules_and_guidelines.pdf" target="_blank" rel="noopener noreferrer">Rules and Guidelines</a>, <a href="https://gcgh.grandchallenges.org/sites/default/files/files/strategies_to_improve_fortification_programs_application_instructions.pdf" target="_blank" rel="noopener noreferrer">Application Instructions</a>, and <a href="https://gcgh.grandchallenges.org/addressing-physiological-barriers-micronutrient-absorption-fortified-foods-frequently-asked" target="_blank" rel="noopener noreferrer">Frequently Asked Questions</a>.
If you are planning to apply to this RFP, we will be hosting a dedicated <a href="https://events.teams.microsoft.com/event/56546af0-f206-4898-9303-a5ebfac6e9a7@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank" rel="noopener noreferrer">webinar</a> on April 2, from 8:30-9:30 AM Pacific Time. This session will provide a comprehensive overview of the RFP details and an opportunity to have your questions answered. To participate in the <a href="https://events.teams.microsoft.com/event/56546af0-f206-4898-9303-a5ebfac6e9a7@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank" rel="noopener noreferrer">webinar</a>, please register and <a href="https://forms.office.com/Pages/ResponsePage.aspx?id=ODhrKdVLbEm9S_RW6nQ7dMKiReMZsCJFmCa42S92Da1UNkJHR1BPNkhSMVNDVDUwNEdKRlBQUExRVS4u" target="_blank" rel="noopener noreferrer">submit your questions in advance</a>. If you cannot attend live, the webinar will be recorded and available on this challenge page after the session.
<h2>Background</h2>
Despite the proven potential of large-scale food fortification to address micronutrient deficiencies, biological constraints may limit its impact in high-burden settings. Chronic inflammation - driven by recurrent infections, environmental enteric dysfunction (EED), poor sanitation, metabolic disorders, or other systemic stressors - can impair intestinal absorption and alter nutrient metabolism. For example, inflammation-induced upregulation of hepcidin reduces iron absorption and mobilization, diminishing the effectiveness of iron fortification even when dietary intake is sufficient. Inflammation and gut barrier dysfunction can also compromise the absorption of other micronutrients, including zinc and fat-soluble vitamins. In parallel, alterations in the gut microbiome may influence micronutrient bioavailability through competitive uptake, reduced endogenous vitamin synthesis, and amplification of mucosal inflammation. These physiological barriers are particularly salient in low-resource contexts where infection and undernutrition co-occur.
<h2>The Challenge</h2>
We are soliciting, through this Grand Challenges RFP, applications that advance innovative approaches to better understand, measure, and mitigate infection, inflammation- and microbiome-mediated constraints that limit the impact of fortification interventions. The goal is to overcome key biological barriers and unlock the full potential of fortification programs to accelerate equitable gains in nutrition and health. Solutions could include novel biomarkers to identify populations with impaired nutrient utilization, fortificant formulations optimized for inflammatory states, adjunctive strategies to restore gut function, or integrated interventions that address infection, gut health, and micronutrient delivery simultaneously. Addressing these biological barriers is essential to unlocking the full potential of fortification programs and accelerating equitable gains in nutrition and health.
The challenge aims to:
<ul>
<li>Identify the physiological parameters that can be modulated to improve micronutrient absorption.</li>
<li>Offer a solution for delivery and effective absorption of micronutrients such as iron in a target population where nutritional interventions have not been effective.</li>
<li>All stages of development would be accepted provided the potential impact is clearly defined. We will particularly consider new innovative product ideas, proof of concept and discovery of new approaches to achieve more effective fortification. The solution is not limited to a product; it can also be a strategic approach and is open to discovery R&amp;D program proposals to address unanswered scientific questions.&nbsp;</li>
</ul>
Funding Level
We will consider proposals for awards of up to $250,000 USD for each project, with a grant term of 18 months. Application budgets should be commensurate with the scope of work proposed. Indirect costs will be considered and should be included in the budget for the up to $250,000 USD award (subject to the&nbsp;<a href="https://docs.gatesfoundation.org/Documents/Indirect_Cost_Policy.pdf" target="_blank" title="https://docs.gatesfoundation.org/documents/indirect_cost_policy.pdf" rel="noopener noreferrer">Gates Foundation's indirect cost policy</a>).
Eligibility Criteria
This initiative is open globally to nonprofit organizations, for-profit companies, international organizations, government agencies and academic institutions. Multi stakeholder collaborations are encouraged. Individuals and organizations classified as individuals for U.S. tax purposes are not eligible to receive an award from the foundation as part of this initiative.&nbsp;
We are looking for proposals that consider:&nbsp;
<ul>
<li>Clear framing of the problem:
<ul>
<li>Explicit articulation of how inflammation, infection, EED, metabolic conditions, or gut dysbiosis limit micronutrient absorption and utilization.</li>
<li>Defined target population and context where fortification effectiveness is currently constrained.</li>
</ul>
</li>
<li>Strong biological rationale
<ul>
<li>Mechanistic understanding (e.g., hepcidin-mediated iron blockade, impaired fat absorption, microbiome–nutrient interactions).</li>
<li>Clear linkage between proposed solution and the underlying physiological barrier.</li>
</ul>
</li>
<li>Innovative and testable solution
<ul>
<li>Novel fortificant formulations, delivery approaches, or adjunctive therapies.</li>
<li>Microbiome-modulating, anti-inflammatory, or gut-repair strategies integrated with fortification.</li>
<li>Development or validation of practical biomarkers to identify or stratify affected populations.</li>
</ul>
</li>
<li>Feasibility and scalability
<ul>
<li>Practical pathway for integration into existing fortification platforms or delivery systems.</li>
<li>Cost-effective design appropriate for low-resource settings.</li>
<li>Consideration of regulatory, manufacturing, and supply chain implications.</li>
</ul>
</li>
<li>Measurement and evaluation plan
<ul>
<li>Clearly articulated theory of change with appropriate outcomes related to micronutrient absorption, status, and functional impact.</li>
<li>Inclusion of inflammation and/or gut function biomarkers where appropriate.</li>
<li>Rigorous study design with defined milestones and go/no-go criteria.</li>
</ul>
</li>
<li>Equity and context relevance
<ul>
<li>Focus on populations with high burdens of infection, undernutrition, or systemic inflammation.</li>
<li>Engagement with local partners and alignment with national nutrition strategies.</li>
</ul>
</li>
<li>Risk assessment and mitigation
<ul>
<li>Consideration of potential unintended consequences (e.g., microbiome disruption, pathogen proliferation, adverse nutrient interactions).</li>
<li>Defined strategy for mitigating and managing scientific and implementation risks.</li>
</ul>
</li>
<li>Team capability
<ul>
<li>Multidisciplinary expertise as required for the topic (nutrition, immunology, microbiome science, implementation science, product development).</li>
<li>Demonstrated ability to translate discovery into scalable impact.</li>
</ul>
</li>
</ul>
We will not fund proposals that focus on:
<ul>
<li>Agricultural and plant biology related topics of research.</li>
<li>Live biotherapeutics which will encounter regulatory challenges for use in food.</li>
<li>Public health data collection and population status assessment.</li>
<li>Policy making and advocacy.</li>
<li>Commercialization and marketing solely.</li>
</ul>

We are soliciting applications that advance innovative approaches to better understand, measure, and mitigate infection, inflammation- and microbiome-mediated constraints that limit the impact of fortification interventions. The goal is to overcome key biological barriers and unlock the full potential of fortification programs to accelerate equitable gains in nutrition and health.

Notice: Applicants will be informed of the decision regarding their project proposals by the end of August 2026.Before applying to this Grand Challenges request for proposals (RFP), applicants should familiarize themselves with the supporting documents, including the <a href="https://docs.gatesfoundation.org/documents/sample-terms-and-conditions.pdf" target="_blank">terms and conditions of the Gates Foundation</a>, the <a href="https://gcgh.grandchallenges.org/sites/default/files/files/ai_accelerate_charitable_giving_rules_and_guidelines.pdf" target="_blank">Rules and Guidelines</a>, <a href="https://gcgh.grandchallenges.org/sites/default/files/files/ai_accelerate_charitable_giving_applications_instructions.pdf" target="_blank">Application Instructions</a>, and <a href="https://gcgh.grandchallenges.org/artificial-intelligence-ai-accelerate-charitable-giving-frequently-asked-questions-faqs" target="_blank">Frequently Asked Questions</a>.If you are planning to apply to this RFP, we will be hosting a dedicated <a href="https://events.teams.microsoft.com/event/f5a7bf0d-a822-4102-a6d3-5e1c5bbeb22f@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank">webinar</a> on March 23, from 7:00-8:00 AM Pacific Time. This session will provide a comprehensive overview of the RFP details and an opportunity to have your questions answered. To participate in the <a href="https://events.teams.microsoft.com/event/f5a7bf0d-a822-4102-a6d3-5e1c5bbeb22f@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank">webinar</a>, please register and <a href="https://forms.office.com/Pages/ResponsePage.aspx?id=ODhrKdVLbEm9S_RW6nQ7dMKiReMZsCJFmCa42S92Da1UNEFaUTNVMjNSUVYzVklVTk0zQkFJQzZWSC4u" target="_blank">submit your questions in advance</a>. If you cannot attend live, the webinar will be recorded and available on this challenge page after the session.<h2>Background</h2>The Gates Foundation's Philanthropic Partnerships Team (PPT) mobilizes resources and cultivates champions for global health and development (GH&amp;D), ensuring that philanthropy helps the world's most vulnerable children survive and thrive.Many people want to make a difference but aren't always sure how to turn that intention into action. Our work helps donors move from interest to impact, working alongside individuals, foundations, advisors, and other sector partners while strengthening the broader systems that support effective giving.Artificial intelligence (AI) is advancing rapidly, reshaping how people access information, make decisions, and engage with the world. For philanthropy, this creates an opportunity to rethink how AI can help donors discover causes and move from interest to action at moments when it matters most.To explore this opportunity, PPT is launching the AI to Accelerate Charitable Giving Grand Challenges RFP to explore how AI can strengthen philanthropic practice and unlock new possibilities for generosity. The Challenge aims to enhance human decision-making with AI-powered tools, data, and insights that help donors give more and give sooner.<h2>The Challenge</h2>We are seeking applications and use cases of AI that address the core question: How might AI support donors to give more and give sooner?This RFP is focused on supporting donor-facing applications and underlying systems of giving that test and demonstrate bold, innovative applications of AI that strengthen and expand philanthropic giving. Desired outputs include generating practical evidence and examples to inform broader practice across the philanthropic sector. We are particularly interested in solutions that increase support for GH&amp;D.For this RFP, GH&amp;D refers broadly to efforts that improve health, economic opportunity, and human well-being in low- and middle-income countries. Within this field, we are especially interested in efforts that reduce preventable mortality, combat infectious diseases, and expand pathways out of extreme poverty, consistent with the <a href="https://www.gatesfoundation.org/ideas/articles/core-mission-child-health-success" target="_blank">Gates Foundation's long-term goals</a>.Projects do not need to focus exclusively on GH&amp;D to be competitive. However, proposals that clearly demonstrate applicability to GH&amp;D challenges, or that generate insights relevant to these priorities, will receive additional consideration. We welcome proposals that address the needs of various donor types including everyday donors, high-net-worth individuals, foundations, or other entities relevant to the challenge areas below.We invite proposals that address at least one of the following challenge areas:1. Help donors connect with causes and understand where to give to achieve their giving goalsHow can AI help people discover causes they care about, understand why they matter, and see where their giving can make a meaningful difference?Many donors want to give but struggle to navigate a crowded and complex landscape of causes, organizations, and appeals. Geographic distance, limited context, and uncertainty about effectiveness can make it difficult to decide where to focus funds or where to begin.We seek solutions that help donors make sense of their options, connect their values to specific opportunities, and build confidence that their contributions can make a meaningful difference across a range of issue areas, including GH&amp;D. Examples include:<ul><li data-list-item-id="e1119d717e2f254346ac2438642d443b5">AI-powered recommendation engines that match donors to issues they care about</li><li data-list-item-id="ef2f75e715cb9668d60946a03784f7554">Personalized learning tools that adapt content, depth, or recommendations as a donor's understanding, interests, and confidence evolve over time</li><li data-list-item-id="e3074b9a63347d7085b0d67561c658259">Immersive or narrative tools that make global issues feel human and relatable</li><li data-list-item-id="e3cb47e736abab2a63e65e2e73a753e3a">Applications that help donors visualize the impact their dollars can create</li></ul>2. Turn interest and intent into donationsHow can AI create pathways to help people move from motivation to meaningful contribution?Many people are motivated to contribute yet fail to follow through because the giving process feels complex, overwhelming, or uncertain.We seek solutions that reduce friction, enable follow-through on the intention to give, and foster sustained engagement beyond a single transaction. Examples include:<ul><li data-list-item-id="e44850b8e62cc33421a466e5bf6f2c31a">Tools that simplify logistical barriers to giving such as cross-border vetting, due diligence, or compliance challenges</li><li data-list-item-id="e4a10799319d50b29f2fb5ebecd9fdbf7">Systems that build community or shared motivation among donors</li><li data-list-item-id="ec587a4e52bdc3ad16179f0e01828a4b0">Designs that make giving feel clear, safe, and meaningful</li></ul>3. Develop the foundational systems and infrastructure that enable AI-powered givingHow can we ensure that AI systems reflect accurate philanthropic data and values so that giving and social impact are part of the information people access every day?As AI increasingly shapes how people learn and make decisions, philanthropy must be represented in the underlying data and tools that drive these systems.We seek focused, practical projects that ensure philanthropic data is visible, credible, and usable by AI systems in ways that support donor understanding, confidence, and giving. Examples include:<ul><li data-list-item-id="e4abd662d2296683cc76b1ede5cd27869">Data pipelines or open standards that expose charitable data to algorithms</li><li data-list-item-id="e4b568313c15cfcd49d62755bd8814e9f">Training models to better recognize and contextualize social impact</li><li data-list-item-id="eb8837b823f5938ba57951500ec0d3464">Applications that make nonprofit websites and payment platforms more interoperable with AI agents (i.e., enabling agents to donate to nonprofit organizations)</li><li data-list-item-id="ee10ab68159ced58dcb27c7549b19a2ba">Solutions that detect and prevent fraud or misuse in donation processes supported by AI</li></ul>AI Ethics and ResponsibilityThe Gates Foundation is committed to harnessing AI for social good while mitigating risks such as bias, inequity, and potential harm, particularly to vulnerable populations. As AI-enabled tools increasingly shape how people access information and make decisions, ethical and responsible use of AI is a foundational consideration that should inform how solutions are designed, tested, and deployed.Applicants are not required to submit a separate response on ethical and responsible AI considerations. However, proposals should demonstrate thoughtful awareness of ethical issues as part of the project's learning and experimentation process, including how potential risks may evolve as systems are tested with real users. The Foundation may request clarification during the application review process as needed.In evaluating proposals, reviewers will consider alignment with the Foundation's AI principles, which are summarized below:<ol><li data-list-item-id="eded8e7bdc4ee5d1d727723537bdb3d2a">AI efforts should align with the Foundation's mission to improve health, reduce poverty, and expand opportunities for those facing the greatest challenges.</li><li data-list-item-id="e3c72dbef8a91996f0c37542b3efc635b">AI solutions should be informed by the needs and perspectives of the community they are intended to serve.</li><li data-list-item-id="e4d61e588eb77308936d63e7df333cc1d">Potential risks and unintended harms should be identified and addressed throughout the AI lifecycle, including monitoring for unintended consequences.</li><li data-list-item-id="e65834f6d98aad78adcbec098bc1243bb">Personal and sensitive data must be handled responsibly and protected from misuse.</li><li data-list-item-id="e48a805760099da57b7706ce6552a4ffe">AI solutions should be designed for broad benefit and be accessible and usable in their intended contexts.</li><li data-list-item-id="ebc332036272c54fe7921c5a56c663bbb">Be transparent about how AI is used, including its purpose, limitations, and governance.</li></ol>Funding LevelWe will consider applications requesting awards up to $150,000 USD per project, with a grant duration of up to 1 year. Budgets should align with the scale and complexity of the proposed work. Indirect costs are allowable and should be included within the total requested funding (subject to the Gates Foundation's <a href="https://docs.gatesfoundation.org/documents/indirect_cost_policy.pdf" target="_blank">indirect cost policy</a>).Travel expenses for in-person convenings with peer grantees hosted by the Gates Foundation will be covered separately by the Foundation. Please only include additional travel costs within your proposed budget.Eligibility CriteriaApplicants must be able to conduct all project activities and reporting in English and be willing and able to participate in up to three virtual and/or in-person learning convenings with peer grantees over the one-year grant period. Eligible entities for this initiative include:<ul><li data-list-item-id="e30e27491f8487956f4db3b801248a93a">Nonprofit and Civil Society Organizations, including registered nonprofits and charities, non-governmental organizations (NGOs), and community-based organizations.</li><li data-list-item-id="eb46b1e1fe307306735845f4748c9cb44">Mission-Driven For-Profit Organizations. For-profit entities that have a clear public-benefit mission aligned with the goals of the RFP are eligible. Funding cannot be used for core commercial product development or general business operations. Proposed activities must advance equitable, responsible, or safe uses of AI in ways that benefit society.</li><li data-list-item-id="efb5eeaa0e5bfaf5004b7e2ddd752c0c7">Consortia, Partnerships, &amp; Collaborative Proposals. Proposals may be submitted through partnerships and other collaborative arrangements. In such cases, one lead organization must serve as the primary applicant and submit the proposal, with partner organizations included as sub-grantees.</li></ul>For this initiative, the following entities are not eligible:<ul><li data-list-item-id="e235e8594bd34cc8d551c707844f89bbf">Individuals and organizations classified as individuals for U.S. tax purposes.</li><li data-list-item-id="ed06df9dc485dc09b716e13ae2a0644d2">Government agencies or departments.</li><li data-list-item-id="efc45f3fc2fb79abc1f952c43ae9a3364">Academic institutions applying independently (unless part of a consortium led by an eligible organization).</li></ul>Proposal RequirementsRecognizing that AI-enabled philanthropic tools are part of an evolving field, we value both measurable donor outcomes and the production of practical learning about what works, what does not, and why. Proposals are encouraged to contribute insights that can inform broader philanthropic practice, even where initial approaches require iteration.We are looking for proposals that:<ul><li class="ck-list-marker-bold" data-list-item-id="e0fd0945a8f391e78b2640acc5f065fd7">Have relevance to the challenge areas<ul><li data-list-item-id="ebdfab14b7906cfbea6057d06dbbdb781">Apply AI in clear, compelling ways to motivate donors to give more and give sooner, directly advancing one or more of the challenge areas. &nbsp;</li></ul></li><li class="ck-list-marker-bold" data-list-item-id="e9c797aa907462102835602f8856e2555">Illustrate expected impact<ul><li data-list-item-id="e653c61c7b8de7479e0689b9dae59eb03">Articulate the meaningful change the project is expected to produce that can inform broader philanthropic practice. &nbsp;</li></ul></li><li class="ck-list-marker-bold" data-list-item-id="ee48b3849d8db9ef0c5d24da703b307c2">Plan for feasibility<ul><li data-list-item-id="e1aab3151f6287df299628af175358cf4">Describe the methodology for pressure-testing and validating the proposed concept, including how AI tools, models, or data pipelines will be tested and evaluated in real-world conditions to assess feasibility. &nbsp;</li></ul></li><li class="ck-list-marker-bold" data-list-item-id="ee7028dd4b22fcbce6ebedeb00e5672ad">Have plans for measuring success<ul><li data-list-item-id="eab59158f33b8501eed1fe09d27eed159">Describe how success will be assessed during the grant period including the indicators or methods used to evaluate both pilot outcomes (i.e., changes in donor behavior or confidence) and learning outcomes.</li><li data-list-item-id="ee80bbdc5182f3f7a8e39f1adfff9a1c2">Explain how these insights will inform broader philanthropic practice. &nbsp;</li></ul></li><li class="ck-list-marker-bold" data-list-item-id="e5da208aee7906610e0c279f779de6014">Describe potential scale<ul><li data-list-item-id="e4b73bb95fe4f3ae75c5584f7a756fe38">Articulate how the project could be sustained, scaled, or shared beyond the grant period.</li><li data-list-item-id="e1893fe9a1f90d4580cc0db379250a3a4">Demonstrate the potential for adaptation or extension across geographies, donor types, philanthropic issues, or giving platforms.</li><li data-list-item-id="e3c62bc005cac92f8dd8ad4cf542126fa">Go beyond narrowly tailored, organization-specific use cases to create insights, tools, or approaches that improve donor experience or decision-making and have broader applicability across the philanthropic ecosystem. &nbsp;</li></ul></li><li class="ck-list-marker-bold" data-list-item-id="ea1cb962f1607c8b3e51a5862c0ed88f7">Use responsible AI practices and safeguards<ul><li data-list-item-id="e0f2f2e302568b55bb19529df7ad49fff">Identify risks related to responsible AI use and describe plans to mitigate them, including fairness, transparency, privacy, and data governance.</li></ul></li></ul>We will not consider funding for proposals that:<ul><li data-list-item-id="eeb279b7e6bacfb279180871eb84d6828">Do not address the core question: How might AI support donors to give more and give sooner?</li><li data-list-item-id="e82ffbd13e68f2d27a33abc57a6b857a7">Do not identify at least one challenge area and demonstrate how the proposed solution meaningfully aligns with it.</li><li data-list-item-id="e14df73e253b6a2dae8e8f02ef4f960c6">Do not apply AI as a central component of the proposed solution.</li><li data-list-item-id="e3fc751ac657cf96792a5f5f995503081">Lack clear relevance to donor decision-making and charitable giving, including meaningful applicability to GH&amp;D.</li><li data-list-item-id="edc320fb6aa6ee4806e92689d3570356b">Do not include a practical plan to test, measure, and generate actionable learning within the grant period that informs broader philanthropic practice.</li><li data-list-item-id="e8928d1dbd06c80df26ecacc25ebab09d">Primarily support commercial product development, general business operations, or private profit.</li><li data-list-item-id="e8d280b23d521d5f163661f182364068c">Fail to demonstrate responsible AI practices, including attention to bias, privacy, transparency, and data governance.</li><li data-list-item-id="e5b3eb04ca67e04903babfe08af55f00e">Request more than $150,000 USD, exceed a one-year grant term, or are submitted by ineligible entities.</li></ul>

Artificial Intelligence (AI) to Accelerate Charitable Giving

Before applying to this Grand Challenges request for proposals (RFP), applicants should familiarize themselves with the supporting documents, including the <a href="https://docs.gatesfoundation.org/documents/sample-terms-and-conditions.pdf" target="_blank" rel="noopener noreferrer">terms and conditions of the Gates Foundation</a>, the <a href="https://gcgh.grandchallenges.org/sites/default/files/files/ai_accelerate_charitable_giving_rules_and_guidelines.pdf" target="_blank" rel="noopener noreferrer">Rules and Guidelines</a>, <a href="https://gcgh.grandchallenges.org/sites/default/files/files/ai_accelerate_charitable_giving_applications_instructions.pdf" target="_blank" rel="noopener noreferrer">Application Instructions</a>, and <a href="https://gcgh.grandchallenges.org/artificial-intelligence-ai-accelerate-charitable-giving-frequently-asked-questions-faqs" target="_blank" rel="noopener noreferrer">Frequently Asked Questions</a>.
If you are planning to apply to this RFP, we will be hosting a dedicated <a href="https://events.teams.microsoft.com/event/f5a7bf0d-a822-4102-a6d3-5e1c5bbeb22f@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank" rel="noopener noreferrer">webinar</a> on March 23, from 7:00-8:00 AM Pacific Time. This session will provide a comprehensive overview of the RFP details and an opportunity to have your questions answered. To participate in the <a href="https://events.teams.microsoft.com/event/f5a7bf0d-a822-4102-a6d3-5e1c5bbeb22f@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank" rel="noopener noreferrer">webinar</a>, please register and <a href="https://forms.office.com/Pages/ResponsePage.aspx?id=ODhrKdVLbEm9S_RW6nQ7dMKiReMZsCJFmCa42S92Da1UNEFaUTNVMjNSUVYzVklVTk0zQkFJQzZWSC4u" target="_blank" rel="noopener noreferrer">submit your questions in advance</a>. If you cannot attend live, the webinar will be recorded and available on this challenge page after the session.
<h2>Background</h2>
The Gates Foundation's Philanthropic Partnerships Team (PPT) mobilizes resources and cultivates champions for global health and development (GH&amp;D), ensuring that philanthropy helps the world's most vulnerable children survive and thrive.
Many people want to make a difference but aren't always sure how to turn that intention into action. Our work helps donors move from interest to impact, working alongside individuals, foundations, advisors, and other sector partners while strengthening the broader systems that support effective giving.
Artificial intelligence (AI) is advancing rapidly, reshaping how people access information, make decisions, and engage with the world. For philanthropy, this creates an opportunity to rethink how AI can help donors discover causes and move from interest to action at moments when it matters most.
To explore this opportunity, PPT is launching the AI to Accelerate Charitable Giving Grand Challenges RFP to explore how AI can strengthen philanthropic practice and unlock new possibilities for generosity. The Challenge aims to enhance human decision-making with AI-powered tools, data, and insights that help donors give more and give sooner.
<h2>The Challenge</h2>
We are seeking applications and use cases of AI that address the core question: How might AI support donors to give more and give sooner?
This RFP is focused on supporting donor-facing applications and underlying systems of giving that test and demonstrate bold, innovative applications of AI that strengthen and expand philanthropic giving. Desired outputs include generating practical evidence and examples to inform broader practice across the philanthropic sector. We are particularly interested in solutions that increase support for GH&amp;D.
For this RFP, GH&amp;D refers broadly to efforts that improve health, economic opportunity, and human well-being in low- and middle-income countries. Within this field, we are especially interested in efforts that reduce preventable mortality, combat infectious diseases, and expand pathways out of extreme poverty, consistent with the <a href="https://www.gatesfoundation.org/ideas/articles/core-mission-child-health-success" target="_blank" rel="noopener noreferrer">Gates Foundation's long-term goals</a>.
Projects do not need to focus exclusively on GH&amp;D to be competitive. However, proposals that clearly demonstrate applicability to GH&amp;D challenges, or that generate insights relevant to these priorities, will receive additional consideration. We welcome proposals that address the needs of various donor types including everyday donors, high-net-worth individuals, foundations, or other entities relevant to the challenge areas below.
We invite proposals that address at least one of the following challenge areas:
1. Help donors connect with causes and understand where to give to achieve their giving goals
How can AI help people discover causes they care about, understand why they matter, and see where their giving can make a meaningful difference?
Many donors want to give but struggle to navigate a crowded and complex landscape of causes, organizations, and appeals. Geographic distance, limited context, and uncertainty about effectiveness can make it difficult to decide where to focus funds or where to begin.
We seek solutions that help donors make sense of their options, connect their values to specific opportunities, and build confidence that their contributions can make a meaningful difference across a range of issue areas, including GH&amp;D. Examples include:
<ul>
<li>AI-powered recommendation engines that match donors to issues they care about</li>
<li>Personalized learning tools that adapt content, depth, or recommendations as a donor's understanding, interests, and confidence evolve over time</li>
<li>Immersive or narrative tools that make global issues feel human and relatable</li>
<li>Applications that help donors visualize the impact their dollars can create</li>
</ul>
2. Turn interest and intent into donations
How can AI create pathways to help people move from motivation to meaningful contribution?
Many people are motivated to contribute yet fail to follow through because the giving process feels complex, overwhelming, or uncertain.
We seek solutions that reduce friction, enable follow-through on the intention to give, and foster sustained engagement beyond a single transaction. Examples include:
<ul>
<li>Tools that simplify logistical barriers to giving such as cross-border vetting, due diligence, or compliance challenges</li>
<li>Systems that build community or shared motivation among donors</li>
<li>Designs that make giving feel clear, safe, and meaningful</li>
</ul>
3. Develop the foundational systems and infrastructure that enable AI-powered giving
How can we ensure that AI systems reflect accurate philanthropic data and values so that giving and social impact are part of the information people access every day?
As AI increasingly shapes how people learn and make decisions, philanthropy must be represented in the underlying data and tools that drive these systems.
We seek focused, practical projects that ensure philanthropic data is visible, credible, and usable by AI systems in ways that support donor understanding, confidence, and giving. Examples include:
<ul>
<li>Data pipelines or open standards that expose charitable data to algorithms</li>
<li>Training models to better recognize and contextualize social impact</li>
<li>Applications that make nonprofit websites and payment platforms more interoperable with AI agents (i.e., enabling agents to donate to nonprofit organizations)</li>
<li>Solutions that detect and prevent fraud or misuse in donation processes supported by AI</li>
</ul>
AI Ethics and Responsibility
The Gates Foundation is committed to harnessing AI for social good while mitigating risks such as bias, inequity, and potential harm, particularly to vulnerable populations. As AI-enabled tools increasingly shape how people access information and make decisions, ethical and responsible use of AI is a foundational consideration that should inform how solutions are designed, tested, and deployed.
Applicants are not required to submit a separate response on ethical and responsible AI considerations. However, proposals should demonstrate thoughtful awareness of ethical issues as part of the project's learning and experimentation process, including how potential risks may evolve as systems are tested with real users. The Foundation may request clarification during the application review process as needed.
In evaluating proposals, reviewers will consider alignment with the Foundation's AI principles, which are summarized below:
<ol>
<li>AI efforts should align with the Foundation's mission to improve health, reduce poverty, and expand opportunities for those facing the greatest challenges.</li>
<li>AI solutions should be informed by the needs and perspectives of the community they are intended to serve.</li>
<li>Potential risks and unintended harms should be identified and addressed throughout the AI lifecycle, including monitoring for unintended consequences.</li>
<li>Personal and sensitive data must be handled responsibly and protected from misuse.</li>
<li>AI solutions should be designed for broad benefit and be accessible and usable in their intended contexts.</li>
<li>Be transparent about how AI is used, including its purpose, limitations, and governance.</li>
</ol>
Funding Level
We will consider applications requesting awards up to $150,000 USD per project, with a grant duration of up to 1 year. Budgets should align with the scale and complexity of the proposed work. Indirect costs are allowable and should be included within the total requested funding (subject to the Gates Foundation's <a href="https://docs.gatesfoundation.org/documents/indirect_cost_policy.pdf" target="_blank" rel="noopener noreferrer">indirect cost policy</a>).
Travel expenses for in-person convenings with peer grantees hosted by the Gates Foundation will be covered separately by the Foundation. Please only include additional travel costs within your proposed budget.
Eligibility Criteria
Applicants must be able to conduct all project activities and reporting in English and be willing and able to participate in up to three virtual and/or in-person learning convenings with peer grantees over the one-year grant period. Eligible entities for this initiative include:
<ul>
<li>Nonprofit and Civil Society Organizations, including registered nonprofits and charities, non-governmental organizations (NGOs), and community-based organizations.</li>
<li>Mission-Driven For-Profit Organizations. For-profit entities that have a clear public-benefit mission aligned with the goals of the RFP are eligible. Funding cannot be used for core commercial product development or general business operations. Proposed activities must advance equitable, responsible, or safe uses of AI in ways that benefit society.</li>
<li>Consortia, Partnerships, &amp; Collaborative Proposals. Proposals may be submitted through partnerships and other collaborative arrangements. In such cases, one lead organization must serve as the primary applicant and submit the proposal, with partner organizations included as sub-grantees.</li>
</ul>
For this initiative, the following entities are not eligible:
<ul>
<li>Individuals and organizations classified as individuals for U.S. tax purposes.</li>
<li>Government agencies or departments.</li>
<li>Academic institutions applying independently (unless part of a consortium led by an eligible organization).</li>
</ul>
Proposal Requirements
Recognizing that AI-enabled philanthropic tools are part of an evolving field, we value both measurable donor outcomes and the production of practical learning about what works, what does not, and why. Proposals are encouraged to contribute insights that can inform broader philanthropic practice, even where initial approaches require iteration.
We are looking for proposals that:
<ul>
<li>Have relevance to the challenge areas
<ul>
<li>Apply AI in clear, compelling ways to motivate donors to give more and give sooner, directly advancing one or more of the challenge areas. &nbsp;</li>
</ul>
</li>
<li>Illustrate expected impact
<ul>
<li>Articulate the meaningful change the project is expected to produce that can inform broader philanthropic practice. &nbsp;</li>
</ul>
</li>
<li>Plan for feasibility
<ul>
<li>Describe the methodology for pressure-testing and validating the proposed concept, including how AI tools, models, or data pipelines will be tested and evaluated in real-world conditions to assess feasibility. &nbsp;</li>
</ul>
</li>
<li>Have plans for measuring success
<ul>
<li>Describe how success will be assessed during the grant period including the indicators or methods used to evaluate both pilot outcomes (i.e., changes in donor behavior or confidence) and learning outcomes.</li>
<li>Explain how these insights will inform broader philanthropic practice. &nbsp;</li>
</ul>
</li>
<li>Describe potential scale
<ul>
<li>Articulate how the project could be sustained, scaled, or shared beyond the grant period.</li>
<li>Demonstrate the potential for adaptation or extension across geographies, donor types, philanthropic issues, or giving platforms.</li>
<li>Go beyond narrowly tailored, organization-specific use cases to create insights, tools, or approaches that improve donor experience or decision-making and have broader applicability across the philanthropic ecosystem. &nbsp;</li>
</ul>
</li>
<li>Use responsible AI practices and safeguards
<ul>
<li>Identify risks related to responsible AI use and describe plans to mitigate them, including fairness, transparency, privacy, and data governance.</li>
</ul>
</li>
</ul>
We will not consider funding for proposals that:
<ul>
<li>Do not address the core question: How might AI support donors to give more and give sooner?</li>
<li>Do not identify at least one challenge area and demonstrate how the proposed solution meaningfully aligns with it.</li>
<li>Do not apply AI as a central component of the proposed solution.</li>
<li>Lack clear relevance to donor decision-making and charitable giving, including meaningful applicability to GH&amp;D.</li>
<li>Do not include a practical plan to test, measure, and generate actionable learning within the grant period that informs broader philanthropic practice.</li>
<li>Primarily support commercial product development, general business operations, or private profit.</li>
<li>Fail to demonstrate responsible AI practices, including attention to bias, privacy, transparency, and data governance.</li>
<li>Request more than $150,000 USD, exceed a one-year grant term, or are submitted by ineligible entities.</li>
</ul>

Artificial intelligence (AI) is advancing rapidly, reshaping how people access information, make decisions, and engage with the world. For philanthropy, this creates an opportunity to rethink how AI can help donors discover causes and move from interest to action at moments when it matters most. To explore this opportunity, PPT is launching the AI to Accelerate Charitable Giving Fund to explore how AI can strengthen philanthropic practice and unlock new possibilities for generosity. The fund aims to enhance human decision-making with AI-powered tools, data, and insights that help donors give more and give sooner.