The Gates Foundation is part of the Grand Challenges partnership network. Visit <a href="https://www.grandchallenges.org" target="_blank">www.grandchallenges.org</a> to view the map of awarded grants across this network and grant opportunities from partners.

Grand Challenges supports exceptional scientists with the expertise to do breakthrough R&amp;D as well as the experience, networks, and skills to excel as scientific leaders. These champions co-create projects with global partners, mobilize key institutions in their countries, and improve public health in their communities and around the world.

Grand Challenges funds innovations to tackle the biggest problems in global health and development. Since 2004, through the Grand Challenges program, we have supported more than 2500 innovation projects in more than 90 countries. &nbsp;

For more than 20 years, Grand Challenges has built trusted relationships with global health funders and researchers. We tap into this powerful network to create unique scientific collaborations with a transformative impact on people's lives. &nbsp;

Innovation happens all along the journey from idea, to experiment, to product or policy, and finally to delivery at scale in communities. We fund innovation projects while supporting an environment of champions, systems, and partnerships to maximize the impact these projects make in people's lives.

The 4 Pillars of the Grand Challenges Ecosystem

Doing groundbreaking science requires the right mix of institutions, policies, and tools. Grand Challenges works with partners in low- and middle-income countries to build or strengthen the capacities they need to succeed in R&amp;D.&nbsp; &nbsp;

Open Grant Opportunities

Professor Abdoulaye Djimdé Named to UN Secretary General's Scientific Advisory Board

<a href="https://gcgh.grandchallenges.org/champion/abdoulaye-djimde" target="_blank">Professor Abdoulaye Djimdé</a> has been appointed to the <a href="https://www.un.org/scientific-advisory-board/en/board-members" target="_blank">United Nations Secretary-General's Scientific Advisory Board</a>, marking an important step in elevating African leaders' voices in global research and science policy conversations.A leading expert in malaria genomics and drug resistance, Prof. Djimdé is focused on building research capacity and scientific collaboration across the continent. He embodies the <a href="https://gcgh.grandchallenges.org/champions" target="_blank">Calestous Juma Science Leadership Fellowship's</a> vision to cultivate scientists who not only drive innovation but also guide decision-making and international cooperation.At a time when the world faces increasingly complex health and development challenges, Prof. Djimdé will bring an important and unique perspective to the board's work on science, technology, and innovation for sustainable development. "Scientific knowledge is strongest when it reflects diverse perspectives," Prof. Djimdé said in response to the appointment, "and I look forward to contributing African experience and expertise to conversations shaping the future of global health and development."

The Grand Challenges family of initiatives fosters innovation to address key global health and development priorities.

Grant Opportunities

Grand Challenges South Africa

Innovations in Cost-Disruptive Tools for Diagnosis and Screening

This Grand Challenge seeks cost-disruptive tools for diagnosis and screening, defined as devices that amortize capital to near-zero incremental cost and consumable $1-class tests that materially reset the cost curve in LMICs while meeting real-world deployment constraints. Accordingly, this initiative aims to translate these cost-disruptive concepts into scalable solutions across high-priority disease areas.

Grand Challenges India

Breakthrough Solutions and Cost-Disruptive Innovations for Screening and Diagnosis

The Cost-disruptive novel screening and diagnosis tools program under GCI seeks transformative novel tools or approaches or devices and ultra-low-cost solutions for screening and/or diagnostics prioritizing near point-of-care and low-incremental-cost formats that can meet real-world operational constraints and really disrupt the accessibility and availability landscape. Here, cost-disruptive screening tools and diagnostics are defined as solutions with a target price point of approximately INR100 or US$1 per test or devices with negligible incremental cost per use. This initiative aims to advance cross-sector, platform, and multimodal solutions to enable scalable screening, same-visit decision-making, and translating the cost-disruptive concepts into scalable solutions across high-priority disease areas.

Grand Challenges

Estimating the Global Burden of Diarrheal Diseases

Before applying to this Grand Challenges request for proposals (RFP), applicants should familiarize themselves with the supporting documents, including the <a href="https://docs.gatesfoundation.org/documents/sample-terms-and-conditions.pdf" target="_blank" rel="noopener noreferrer">terms and conditions of the Gates Foundation</a>, the <a href="https://gcgh.grandchallenges.org/sites/default/files/files/global_burden_of_diarrheal_diseases_rules_and_guidelines.pdf" target="_blank" rel="noopener noreferrer">Rules and Guidelines</a>, <a href="https://gcgh.grandchallenges.org/sites/default/files/files/global_burden_of_diarrheal_diseases_application_instructions.pdf" target="_blank" rel="noopener noreferrer">Application Instructions</a>, and <a href="https://gcgh.grandchallenges.org/estimating-global-burden-diarrheal-diseases-frequently-asked-questions-faqs" target="_blank" rel="noopener noreferrer">Frequently Asked Questions.</a>
If you plan to apply to this RFP, we will host a dedicated <a href="https://events.teams.microsoft.com/event/705ad6ae-3dba-4300-960a-24954b5f9f04@296b3838-4bd5-496c-bd4b-f456ea743b74" target="_blank" rel="noopener noreferrer">webinar</a> on May 14, 2026, 8:00-9:00 a.m. US PST. The session will provide an overview of the RFP and include time for questions. To attend, please register and <a href="https://forms.office.com/r/DdDppwuAFU" target="_blank" rel="noopener noreferrer">submit your questions in advance</a>. A recording will be posted on the challenge page following the session for those unable to join live.
Please note that the webinar has reached full capacity and registration is now closed. A recording will be posted on this page within 24 hours after the event concludes.
The Gates Foundation invites proposals to generate independent, policy-relevant estimates of the global burden of diarrheal diseases, with a focus on mortality and morbidity in children under five living in low- and middle-income countries (LMICs).
<h2>Background</h2>
Reliable burden estimates are essential for prioritizing disease syndromes and pathogens and for guiding investments in prevention, treatment, and product development. However, estimating diarrheal mortality and morbidity and pathogen-specific burden remains challenging because direct mortality and morbidity data are limited in many LMIC settings, etiologic data are uneven and often derived from studies of cases rather than deaths, and attribution methods must reconcile imperfect diagnostics, multiple pathogens, incomplete surveillance, and sparse location-specific evidence. Modelled estimates of global burden of disease can help overcome data sparsity, and multiple independent estimates would be valuable for triangulating estimates of burden and understanding key drivers of differences. Differences across existing estimates may arise from variation in data inputs, mortality envelopes, etiologic attribution methods, model structure, and assumptions.
The Foundation seeks to support independent estimation efforts that inform the overall burden of diarrhea and pathogen-specific contributions, clarify key sources of uncertainty, and produce decision-useful estimates for policymakers, researchers, and global health partners.
Multiple burden estimates would help inform the relative importance of diarrhea as a cause of mortality and morbidity in children under five and clarify which pathogens are responsible for the largest share of burden.
<h2>The Challenge</h2>
Through this Grand Challenge, the Foundation seeks to support organizations with strong epidemiologic and quantitative modeling capabilities to produce credible, transparent, and decision-useful estimates of diarrheal disease burden in LMICs.
Applicants should propose approaches that can generate a minimum core set of estimates for the year 2025 and, where feasible, build longer-term analytic capacity in LMICs.
Scope of Work
Proposals must include plans to generate, at minimum:
<ul>
<li>Country-specific estimates of total diarrheal mortality burden in children under five.</li>
<li>Country-specific pathogen-attributed mortality burden for children under five.</li>
<li>Estimates reported as both total number of diarrhea-attributed deaths, pathogen-specific fractions, and mortality incidence rates, centered on 2025, using the most recent available data and appropriate methods for projection, interpolation, or extrapolation where needed.</li>
<li>When possible, country-specific estimates of total and/or pathogen-attributed morbidity burden, measured as all cause or pathogen-specific disease cases, severe disease cases, or hospitalizations and presented as the total numbers, pathogen-specific fractions, and/or incidence rates.</li>
<li>Estimates reported as point estimates with confidence/uncertainty intervals.</li>
<li>Geographic scope: may include proposed estimates for a single country, region, all LMICs, or global. While proposals may focus on a single country, region, all LMICs, or global estimates, preference will be given to proposals focused on geographies where diarrheal mortality is expected to be highest or where improved estimates of both mortality and morbidity would have particularly high programmatic relevance, including but not limited to India, Nigeria, and sub-Saharan Africa.</li>
</ul>
We will consider fully independent modeling frameworks or partial re-estimation based on existing burden estimates and using alternative assumptions or datasets. Proposals must provide sufficient technical documentation for external review and should include planned approaches for etiologic attribution of both disease cases and deaths, including plans for adjudicating coinfections / multiple pathogens detected, at a minimum.
At minimum, proposals should include estimates for the following pathogens:
<ul>
<li>Rotavirus</li>
<li>Shigella</li>
<li>Adenovirus 40/41</li>
<li>Norovirus GII</li>
<li>ST-ETEC</li>
<li>Cholera (endemic)</li>
<li>Cryptosporidium</li>
<li>Campylobacter</li>
</ul>
Applicants may also propose additional analyses beyond the minimum required set, such as:
<ul>
<li>Expansion to broader age groups</li>
<li>Expansion to additional diarrhea etiologies</li>
<li>Additional burden outputs, including DALYs or costs</li>
<li>Historical trend analyses</li>
<li>Regional or global geographic aggregation</li>
</ul>
However, all proposals must clearly deliver the minimum required output set above.
Applicants should recognize that this opportunity is intended not only to produce burden estimates, but also to improve confidence in the evidence base used for priority setting. We are seeking outputs that can inform syndrome and pathogen prioritization and that are interpretable by global and country decision-makers. Proposals should therefore address how resulting estimates will be interpreted, compared with existing approaches, and made useful to stakeholders. There should also be clear communication of uncertainty and sensitivity to assumptions.
What we are looking for:
The Foundation is particularly interested in proposals that demonstrate:
<ul>
<li>Scientific rigor and methodological transparency</li>
<li>Credible alternatives or complements to existing estimates (e.g. IHME Global Burden of Disease)</li>
<li>Strong use of available epidemiologic, surveillance, and etiologic data</li>
<li>Clear assumptions and sensitivity analyses</li>
<li>Practical relevance for decision-makers in global health and child survival</li>
<li>Potential to strengthen analytic and modeling capacity in LMIC institutions or partnerships</li>
</ul>
We will not fund proposals that:
<ul>
<li>Do not focus on diarrheal burden estimation</li>
<li>Do not include mortality estimates for children under five</li>
<li>Do not provide a clear methodological approach for pathogen attribution</li>
<li>Rely primarily on literature review without a substantive analytic plan</li>
<li>Do not specify underlying data sources and handling of uncertainty</li>
<li>Are intervention studies or surveillance implementation</li>
<li>Do not clearly explain how outputs will improve on, complement, or interrogate existing burden estimates</li>
<li>Are not submitted by an LMIC-based institution, led by an LMIC institution in partnership, or part of a global consortium with meaningful LMIC partner engagement&nbsp;</li>
<li>Do not explicitly address how they will generate estimates for the minimum required outputs</li>
</ul>
Eligibility
This opportunity is open to research institutes, nonprofit organizations, for-profit companies, international organizations, government agencies, and academic institutions. with demonstrated expertise in disease burden estimation, epidemiology, biostatistics, and related quantitative methods.
We welcome proposals from:
<ul>
<li>LMIC-based institutions</li>
<li>Partnerships led by LMIC institutions</li>
<li>Global consortia that include meaningful LMIC partner engagement and capacity development</li>
</ul>
Applications that pair high-quality analytic output with intentional LMIC capacity building are especially encouraged.
Funding Level
We will consider applications requesting up to $1.5 million USD per project, with a maximum grant duration of two years. Proposed budgets should be commensurate with the scale and complexity of the work. Indirect costs are allowable and must be included within the total requested funding, in accordance with the Gates Foundation’s <a href="https://docs.gatesfoundation.org/documents/indirect_cost_policy.pdf" target="_blank" rel="noopener noreferrer">indirect cost policy</a>).

The Gates Foundation invites proposals to generate independent, policy-relevant estimates of the global burden of diarrheal diseases, with a focus on mortality and morbidity in children under five living in low- and middle-income countries (LMICs).