Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some of the same problems, but from differing perspectives.
Environmental exposure to antibiotics is correlated well with AMR. The present study proposes the development of high throughput screening (HTS) technique of 125 antibiotics from environmental samples like water (from river, aquifers and food sources like egg and raw meat). A novel in-vitro method will be adopted to correlate AMR with the environmental levels of antibiotics found in Delhi-NCR region and derive safe levels of antibiotics that should be permissible in the environment.
The Inali Arm solves a problem that derails the lives of millions of people across the world. India alone is home to more than 22 million people with disabilities, with children making up nearly 8 million of that number. Due to cost and lack of accessibility, most of these people never get the help they need. The proposal intends to develop indigenous low-cost, affordable arm to for thousands of people who are living without any prosthetic care.
Studies promoting egg consumption among women and children in lower middle-income countries (LMICs) show that growth indicators are significantly improved in children who consume eggs consistently. However, many states in India are chronically egg deficit, unable to fulfil their daily egg demand. The study is exploring the use of powdered-eggs in place of fresh eggs as they are cheaper and have a longer shelf life. Furthermore, the product is convenient to use, easy to transport, store and can be incorporated as an ingredient into Indian recipes and daily diets.
Wireless Capsule Endoscopy (WCE) has the potential to become the leading screening technique for the entire gastrointestinal (GI) tract. Till date, no Artificial Intelligence (AI) based diagnostic aid has been developed to assist endoscopists in identification and classification of abnormalities post the WCE procedure. The core objective of this proposal is to deliver a first-of-its-kind, multi-platform, AI-powered, fully automated diagnostic web application for real-time detection and classification of multiple abnormalities (angioectasias, aphthae, bleeding, chylous cysts, villous oedema, lymphangiectasia, polypoids, stenosis and ulcers).
The study proposes a novel low-cost health monitor with 4 components. The first component is a vibration sensor pad which when placed under the mattress detects heart and respiration signal using ballistocardiograph. The respiration signal obtained is also used for sleep apnea screening and the heart signal is also screened for arrhythmia instances and monitoring cardiac cycles (LVET, ICT, IRT). The second component is a bedside unit for data acquisition, processing & communication (GSM & WiFi) with alert system. The third component is a bluetooth enabled wireless finger pulse oximeter to measure oxygen saturation. The final component is a wearable 3D axis accelerometer for fall detection. This data is available in Realtime to the geriatric caregivers who can also setup and receive customized alerts for abnormal vitals signs and fall. The proposed solution is a novel low-cost easy-to-use health monitor that tracks heart and respiration rate, sleep cycles, cardiac cycles, oxygen saturation and detects fall.
The proposed novel solution besides targeting "safe delivery" intends to promote "healthy infant" for a healthy childhood. The cost effective, resource independent, foldable and portable, environmentally sustainable (no disposable single use item, zero waste generation and skill independent) kits are based on FDA approved chlorine dioxide sterilizing and releasing platform. It can be effectively used to sterilize all the essentials required for SAFE DELIVERY (i.e. surgical tools, hand gloves, clothing item, scissors and clips). It can also be used for sterilizing infant gears, disinfecting water and provides convenient hand hygiene.
Neutrophil CD64 and procalcitonin present in the peripheral blood are the most promising biomarkers of neonatal early and late onstage sepsis. However, detection of biomarkers from other body fluids, such as urine, appears to be more feasible, considering the non-invasive sample collection and their accessibility from neonates. Additionally, the urinary biomarkers, which includes cytokines such as IL-8, IL-10 and MCP-1, are elevated during early presumed infection. Thus, development of a PoC for an early detection of infection, which will assess biomarkers from urine, will not only be novel but also provide a beneficial solution to this grave health issue in neonates.
Current methods for detection of malnutrition use physical attributes but not nutrient level. Proposed device relates to technique for rapid quantification of multiple clinically important nutrients in biological fluids for timely interventions. The 3-tiered solution proposes: 1. Colorimetry based estimation of multi-nutrients on single test strip 2. Accurate quantification by a smartphone app 3. Cloud based data collection and analytical reporting for establishing PoC diagnosis.
GenRobotics aims to eradicate the scourge of manual scavenging by changing Manholes to Roboholes, thereby enable the socio-economic transformation of one of the most marginalised sections of society. The world’s first manhole cleaning robot-Bandicoot does all the tasks that are manually done inside the manhole. The robot operations can be controlled and monitored by the control panel placed outside manhole. It pulls out the solid waste material which is the real reason of blockage, with its specially designed human comparable robotic arm and unblock the sewer line system which help liquid waste to flow through sewer line system as usual.
Old age makes geriatric population vulnerable to non-communicable disorders like kidney disorder, cardiovascular disease, stroke, hypertension and diabetes nephropathy. Micro-albumin concentration in urine is a well-established biomarker for early diagnosis and management of these comorbidities. To address this gap, the current proposal aspires to deploy a novel self-monitoring Point-of-care (PoC) device to bring independent living with minimum health care support in resource limited settings.