Our goal is to engineer thermostable microneedle (MN) patches to deliver tetanus vaccine. Instead of expecting pregnant women from remote areas to travel far for vaccination, we propose to provide microneedle patches designed to be applied to skin like a skin plaster. Their small size, and lack of vaccine reconstitution, improves on standard practice. MNs are formulated to dissolve releasing the vaccine quickly, with no biohazard sharp waste.

In collaboration with the Rwandan Ministry of Health National Research Laboratory, and our on the ground implementing partners, Nanobiosym will reduce HIV related deaths in infants by scaling up access to its novel POC nanodiagnostic platform by validating Nanobiosym's proprietary Point-of-Care Gene-RADAR diagnostic platform's ability to measure HIV positive mothers' viral load thereby ensuring they are responding to ART and reducing their chances of transmitting HIV to their child in-utero, at birth, or during the breastfeeding period.

The objective of the study is to evaluate the safety and feasibility of the Odon device, a low cost, easy to use technological innovation, in assisting vaginal delivery in singleton term pregnancies during the second stage of labor. Interim evaluation of the device for safety and feasibility showed no major severe adverse events among women or infants enrolled in the study. The experience suggests that the device is easy to use and allows successful expulsion of the baby. The Odon device could play a major role in improving intrapartum obstetric care in the most vulnerable populations with the least access to well-trained specialists, extraction procedures or timely caesarean section.

Effective resuscitation could reduce intrapartum related neonatal deaths by 30%, and deaths from prematurity by 10%, creating the potential to save 347,200 babies annually. However, one in five trained healthcare professionals (HCPs) fail to perform the resuscitation technique correctly, and those that do, often experience a rapid decline in proficiency. Our Augmented Infant Resuscitator's advanced training capabilities, instant feedback mechanism, and objective self-audit and retraining abilities will maximize and sustain gains from effective resuscitation. The AIR prototype provides instant feedback to users about effective ventilation. This is measured using inexpensive instrumentation that calculates ventilation rate, air volume and air pressure delivered by the bag-valve-mask (BVM) across the resuscitation face-mask. These parameters correlate with the four most common mistakes that result in ineffective resuscitation: 1) Failed seal at the face-mask interface resulting in failure to inflate the lungs; 2) Blocked airways; and 3) Wrong ventilation frequency 4) Insufficient/shallow lung inflation. Each of these mistakes can cause death or brain damage. AIR also records performance on an internal memory card for future feedback, improving HCPs training by identifying persistent gaps in technique.