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Bill & Melinda Gates Foundation

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Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some of the same problems, but from differing perspectives.

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Scaling Up Simprints: Mobile Biometrics for MNCH Care in Bangladesh

Dan Storisteanu SimPrints Technology Ltd.Cambridge, United Kingdom
Grand Challenges for Development
Saving Lives at Birth
1 Mar 2018

Scaling up Simprints: Mobile Biometrics for MNCH Care in Bangladesh

Scaling the BEMPU Hypothermia Alert Device Across Indian and International Markets

Ratul NarainBEMPU TechnologiesBengaluru, Karnataka, India
Grand Challenges for Development
Saving Lives at Birth
1 Mar 2018

Scaling the BEMPU hypothermia alert device across Indian and international markets

Safer Deliveries Using Point-of-Care Decision Support and Monitoring

Marc MitchellD-Tree InternationalWeston, Massachusetts, United States
Grand Challenges for Development
Saving Lives at Birth
29 Nov 2016

The Safer Deliveries project will improve the ability of nurses and midwives to identify danger signs for a woman and her baby during the critical period of labor and delivery and link these measures to specific decision support rules that guide the health worker in taking corrective action. Using ultra-low-cost disposable ECG leads, D-tree International will build a phone based device that provides continuous tracking of fetal and maternal heart rate and uterine contractions during labor and delivery leading to more timely and effective interventions to save the life of the mother and infant.

Reduction of Maternal Death Through Postpartum Hemorrhage: A Highly Heat-Resistant Form of Oxytocin that Does Not Require Injection

Robert OffordThe Mintaka Foundation for Medical ResearchGeneva, Switzerland
Grand Challenges for Development
Saving Lives at Birth
4 Jan 2016

We will seek to demonstrate measurable levels of the first inhalable formulation of oxytocin in blood and measurable biological effects of inhalation, all this with no seriously adverse side effects. Success will provide the essential platform for the further steps required to move into a first clinical trial. Our ultimate goal is licensure and distribution in affected areas: providing every mother on the planet with access to a life-saving drug when in labor.

Rapid Diagnostic Test for Urinary Adipsin Biomarker-Based Test for Improving PE Screening in Low-Resource Settings

Nicole AdvaniProgram for Appropriate Technology in Health (PATH)Seattle, Washington, United States
Grand Challenges for Development
Saving Lives at Birth
1 Mar 2018

Rapid diagnostic test for urinary adipsin biomarker-based test for improving PE screening in low resource settings

Quadruple Fortified Salt: An Efficient and Scalable Vehicle for Simultaneous Delivery of Iron, Folic Acid, Vitamin B 12 and Iodine in Low-Resource Settings

Levente DiosadyUniversity of TorontoToronto, Ontario, Canada
Grand Challenges for Development
Saving Lives at Birth
1 Jan 2016

Salt is universally consumed at a constant, predictable level independently of social status. Our approach is to develop innovative technology for incorporating these micronutrients into salt at levels that can have a significant beneficial health effect. Our objective is to develop a stable premix in the laboratory, test its long-term stability in salt, and scale up the process for premix production in pilot scale tests in India.

Outpatient Treatment of Neonatal Sepsis by the Rectal Administration of Gentamicin

David McAdamsProgram for Appropriate Technology in Health (PATH)Seattle, Washington, United States
Grand Challenges for Development
Saving Lives at Birth
6 Dec 2016

We propose to investigate the feasibility of a needle-free method of administration for the antibiotic gentamicin via the rectal route. Under this project we would conduct laboratory release studies, preclinical rectal bioavailability studies and stakeholder interviews to assess the feasibility of novel concept. This delivery method would improve access to outpatient treatment of neonatal sepsis in areas serviced by low level healthcare providers and would remove the inherent risks associated with parenteral delivery.

NIFTY: A Neonatal Intuitive Feeding Technology for preterm infants who have difficulty breastfeeding

Trish CoffeyProgram for Appropriate Technology in Health (PATH)Seattle, Washington, United States
Grand Challenges for Development
Saving Lives at Birth
1 May 2016

The NIFTY cup's extended reservoir off the cup lip optimizes efficient milk delivery, and mothers can directly express into the 60-ml cup. The NIFTY cup's soft silicone material protects the infant's mouth from injury. The cup has embossed volume measurements to track intake; is designed to enhance finger and wrist control over milk flow; and is made with quick-drying, UV- and heat-resistant, durable, affordable silicone that can be boiled for sterilization. Our project aims to 1) generate an evidence base by validating the NIFTY cup in a hospital in Ethiopia and 2) shape the sub-Saharan Africa market by identifying a commercialization partner and developing a go-to market strategy and global advocacy plan.

Newborn Heart Rate as a Catalyst for Improved Survival

Casey LowmanAmerican Academy of PediatricsItasca, Illinois, United States
Grand Challenges for Development
Saving Lives at Birth
1 Mar 2018

Newborn Heart Rate as a catalyst for improved survival

Neonate Biometric Scanner for Frontline Health Workers

Dan Storisteanu SimPrints Technology Ltd.Cambridge, United Kingdom
Grand Challenges for Development
Saving Lives at Birth
1 Mar 2018

Neonate Biometric Scanner for Frontline Health Workers

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