Skip to main content

Grand Challenges

Bill & Melinda Gates Foundation

Main menu

  • About
  • Challenges
  • Awarded Grants
  • News
  • Grant Opportunities
  • Search

You are here

  1. Home
  2. Awarded Grants
  3. 2013
  4. 2011
  5. 2010

Print link

Print

Awarded Grants

Filter by Initiative

  • Grand Challenges Explorations Apply Grand Challenges Explorations filter (481)
  • Grand Challenges for Development Apply Grand Challenges for Development filter (50)
  • Grand Challenges Apply Grand Challenges filter (28)
  • Grand Challenges Brazil Apply Grand Challenges Brazil filter (12)
  • Grand Challenges Canada Apply Grand Challenges Canada filter (9)
  • Grand Challenges India Apply Grand Challenges India filter (4)

Filter by Challenge

Filter by Awarded Year

  • 2019 Apply 2019 filter (121)
  • 2018 Apply 2018 filter (129)
  • 2017 Apply 2017 filter (98)
  • 2016 Apply 2016 filter (162)
  • 2015 Apply 2015 filter (171)
  • 2014 Apply 2014 filter (152)
  • (-) Remove 2013 filter 2013 (184)
  • 2012 Apply 2012 filter (244)
  • (-) Remove 2011 filter 2011 (258)
  • (-) Remove 2010 filter 2010 (142)
  • 2009 Apply 2009 filter (157)
  • 2008 Apply 2008 filter (105)
  • 2006 Apply 2006 filter (1)
  • 2005 Apply 2005 filter (43)

Filter by Country

Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some of the same problems, but from differing perspectives.

Sort by:
Date Awarded
Title (A-Z)
10
25
50
100

Use of Multi-Criteria Decision Analysis to Assess Impacts of Rabies, Brucellosis and Their Interventions

Syed AbbasPublic Health Foundation of IndiaNew Delhi, Delhi, India
Grand Challenges Explorations
Human and Animal Health
22 Oct 2013

Syed Abbas of the Public Health Foundation of India in India, with colleagues Manish Kakkar and Krishna Rao, will adapt a Multi-Criteria Decision Analysis approach to integrate different perspectives from the animal, environment, and human health sectors on the impact and intervention scenarios of zoonotic diseases, which infect animals and humans. The impact of a single disease and the effects of a specific intervention strategy affect the sectors in different ways. They will test their approach by consulting major stakeholders in each sector on the impact of intervention on one human disease (rabies) and one animal disease (brucellosis) within their sector, and use these to develop weights that allow direct comparisons across the sectors in order to promote more effective collaborations that can better protect health and food security.

Interoperable Data for Poverty Eradication

Simon ParrishDevelopment Initiatives Poverty Research LtdBristol, United Kingdom
Grand Challenges Explorations
Data Systems
22 Oct 2013

Simon Parrish of Development Initiatives in the United Kingdom will create a toolkit for the generation of a single interoperable dataset from diverse databases to help more users better assess the impact of resource spending in developing countries. Accurately assessing the impact of spending in areas such as health and education in specific locations, and the ability to directly compare different locations, is necessary to effectively eradicate poverty. However, the relevant datasets are currently incompatible or difficult to access by the appropriate communities. Parrish will partner with a Ugandan organization and community leaders in two districts to identify relevant datasets and the pertinent information they contain. This will be used to generate a merged dataset along with a web-based tool for local users, which will then be evaluated for interoperability and usability.

The One Health Metric: Measuring the Poverty Impacts of Disease

Kim ThomsonUniversity of ReadingReading, United Kingdom
Grand Challenges Explorations
Human and Animal Health
22 Oct 2013

Kim Thomson of the University of Reading in the United Kingdom will develop a combined metric to account for the impact of both human and animal diseases on poverty. This one health metric will incorporate two recognized poverty metrics: one that measures the poverty impact of individual livestock diseases, and the other that measures the poverty impact of human disease, which reflects both quantity and quality of life years. This will enable comparisons of poverty impact both between different diseases and across different populations. Thomson will devise the metric using available global health and disease datasets, and assess its reliability by field-testing it using data from Kenyan households.

Stored Energy Solar Stove Technology

Derek Dunn-RankinUniversity of California, IrvineIrvine, California, United States
Grand Challenges Explorations
Women Farmers
22 Oct 2013

Derek Dunn-Rankin of the University of California, Irvine in the U.S. will refine the design of an energy storage device that collects and stores solar energy to enable indoor or evening cooking in developing countries. Traditional stoves use wood or animal dung as an energy source, which are labor-intensive methods, environmentally unfriendly, and potentially deleterious to health. The storage device consists of an insulated box containing potassium nitrite and sodium nitrite, which undergo a solid-to-liquid phase transition at a certain temperature. During re-solidification, the stored energy is slowly released to provide a stable heat source that can be used to cook foods such as bread and rice. They will work to optimize the design to improve performance and reduce the cost of the device, in order to move towards mass production.

Nano-Beads Adjuvant for Theileria parva Vaccine

Jean-Pierre ScheerlinckUniversity of MelbourneMelbourne, Victoria, Australia
Grand Challenges Explorations
Human and Animal Health
21 Oct 2013

Jean-Pierre Scheerlinck of the University of Melbourne in Australia will develop an effective vaccine against the parasite Theileria parva, which causes East Coast Fever in cattle, by conjugating parasite lysates to nanobeads, which act as an adjuvant to induce a strong immune response. Upon infection, the parasite enters cells of the immune system making classical vaccination strategies that induce antibody responses ineffective. Protecting these animals against infection instead requires a cytotoxic T cell immune response. Nanobeads are inexpensive, inert, 40nm diameter beads that, when covered with antigens, can induce a cytotoxic T cell response in humans. Scheerlinck will generate parasite lysates from infected lymphocytes grown in the laboratory as a source of antigens, conjugate it covalently to nanobeads, and inject them into cattle to test for a robust cytotoxic T cell response and protection against Theileria parva infection.

Moma's Farm

Mustafa Ojonuba JibrinAhmadu Bello UniversityZaria, Nigeria
Grand Challenges Explorations
Women Farmers
21 Oct 2013

Mustafa Ojonuba Jibrin from Ahmadu Bello University in Nigeria will produce a participatory reality TV show to promote the use of draught animals to help female farmers in Nigeria with ploughing, ridging, and weeding. Female farmers are far less likely to use draught animals for farming as they have less access than male farmers, and lack skills and confidence, and it is considered culturally unacceptable for women to use them. As television and social media are widely available in Nigeria, he will develop a reality show using male and female participants with incentives to encourage public voting and thereby viewing, to promote female use of draught animals and increase cultural acceptance of the practice.

Integrated Human and Animal Vaccination Delivery

Ndadilnasiya Endie WaziriAfrican Field Epidemiology NetworkAbuja, Nigeria
Grand Challenges Explorations
Human and Animal Health
21 Oct 2013

Ndadilnasiya Endie Waziri of the the African Field Epidemiology Network in Nigeria will determine whether combining child and animal vaccination programs can reduce the incidence of vaccine preventable diseases in Nigeria. Current programs often fail to reach highly mobile rural communities who raise livestock. This dependency on livestock may make them more agreeable to vaccination programs that offer protection for both their animals and themselves, which would also optimize the use of limited health care resources. They will use GPS-enabled smart phones to map these nomadic communities and their movements. A vaccination strategy will be designed, and key workers in the human and animal health sector will be trained to educate the communities and deliver vaccinations against a variety of diseases including polio for humans and anthrax for livestock. Coverage and cost-effectiveness of the strategy will be evaluated.

Water Catchment, Storage and Irrigation for Women Farmers

Rachel HessMennonite Economic Development AssociatesLancaster, Pennsylvania, United States
Grand Challenges Explorations
Women Farmers
21 Oct 2013

Rachel Hess of the Mennonite Economic Development Associates in the U.S. will work in Ghana to test different models of water catchment and storage and irrigation systems to promote dry season cultivation in small farms in the north part of the country. Food production by women farmers in Ghana's northern savannah region is restricted to a single season of rainfall and is not sufficient to circumvent malnutrition. Low-cost water storage systems are available, but need to be brought to these rural areas and adapted to their needs and capabilities. They will recruit users to evaluate four models for ease of assembly and use, and select at least two to evaluate performance in 15-20 households, and do cost-benefit analyses.

C. elegans as a Targeted Molecular Surrogate for Filarid Parasites

Kaveh AshrafiUniversity of California San FranciscoSan Francisco, California, United States
Grand Challenges Explorations
Neglected Tropical Diseases
21 Oct 2013

Kaveh Ashrafi of the University of California, San Francisco in the U.S. will use the free-living model nematode worm Caenorhabditis elegans as a molecular platform to identify new drugs capable of killing adult filarial parasitic worms, which cause serious infections. C. elegans is a non-parasitic model organism that can be easily grown and manipulated in the lab, unlike related parasitic Roundworms. Ashrafi will genetically engineer C. elegans to carry the parasitic version of the gene encoding phosphodiesterase-4, inhibition of which is known to kill the parasites. This mutant, as well as one carrying the human version of the same gene, will be used in screens to identify drug candidates that can selectively kill adult parasites.

The Condom Applicator Pack (CAP)

Michael RutnerHouse of Petite Pty. Ltd.Sydney, New South Wales, Australia
Grand Challenges Explorations
Next Generation Condom
18 Oct 2013

Michael Rutner and Russell Burley of House of Petite Pty. Ltd. in Australia will build and test a universal condom applicator pack (CAP), which is designed to ensure that male condoms can be quickly, accurately, safely and easily fitted. Condoms are currently mostly applied manually, which can increase the risk of disease transmission or unplanned pregnancy due to damage to the condom during fitting or incorrect positioning, for example. The CAP and condom will be provided in the same packaging, and the mechanism is designed to ensure correct positioning and avoid damage. They will review materials for the CAP and build prototypes to be tested in the lab and in trials, as well as performing preliminary production and marketing.

Pages

  • First page
  • Previous page
  • Page 1
  • Page 2
  • Page 3
  • Currently on page 4
  • Page 5
  • Page 6
  • Page 7
  • Page 8
  • Page 9
  • …
  • Next page
  • Last page
Sort by:
Date Awarded
Title (A-Z)
10
25
50
100

Contact us

Contact us

  • General Inquiries
  • Media Inquiries

Footer - Receive Updates

Receive updates

  • Sign up for email updates

Footer

  • Privacy Policy and Terms of Use
© 2003-2019. Grand Challenges. All Rights Reserved.

PLEASE REVIEW OUR UPDATED PRIVACY & COOKIES NOTICE

This site uses cookies and similar technologies to store information on your computer or device. By continuing to use this site, you agree to the placement of these cookies and similar technologies. Read our updated Privacy & Cookies Notice to learn more.