Skip to main content

Grand Challenges

Bill & Melinda Gates Foundation

Main menu

  • About
  • Challenges
  • Awarded Grants
  • News
  • Grant Opportunities
  • Search

You are here

  1. Home
  2. Awarded Grants
  3. Grand Challenges

Print link

Print

Awarded Grants

Filter by Initiative

  • (-) Remove Grand Challenges filter Grand Challenges (179)

Filter by Challenge

Filter by Awarded Year

  • 2019 Apply 2019 filter (23)
  • 2018 Apply 2018 filter (16)
  • 2016 Apply 2016 filter (26)
  • 2015 Apply 2015 filter (19)
  • 2014 Apply 2014 filter (1)
  • 2013 Apply 2013 filter (3)
  • 2012 Apply 2012 filter (22)
  • 2011 Apply 2011 filter (25)
  • 2006 Apply 2006 filter (1)
  • 2005 Apply 2005 filter (43)

Filter by Country

Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some of the same problems, but from differing perspectives.

Sort by:
Date Awarded
Title (A-Z)
10
25
50
100

Finding Solutions to Thrive After Birth Asphyxia in Africa

Pia WintermarkResearch Institute of the McGill University Health CentreMontreal, Quebec, Canada
Grand Challenges
Annual Meeting Call-to-Action
1 Mar 2019

Pia Wintermark of McGill University in Canada and Cally Tann of the London School of Hygiene & Tropical Medicine in the United Kingdom will establish a pilot cohort in Uganda of term newborns who suffered from asphyxia at birth, which means that their brain and other organs did not receive enough blood or oxygen, and conduct a clinical test of a novel neurorestorative agent (i.e., to repair brain injuries) to see if it can improve early brain development in this setting. Birth asphyxia and the resulting neonatal encephalopathy is the third leading cause of mortality in infants under five and leads to significant brain damage and long-term neurodevelopmental morbidities. In a rat model of term neonatal brain damage, they found that a compound, sildenafil, reduced brain damage and inflammation, and increased nerve cell growth. This compound has already proven safe for use in humans for other purposes. They will first assemble a pilot cohort of 100 neonates with neonatal encephalopathy in Uganda, and clinically evaluate them over the first three months of age to better characterize the disease in this setting. From this cohort, 30 newborns will be selected to test whether daily treatment of sildenafil from day 2 to day 9 of life can improve brain growth and development and is a feasible and acceptable neurorestorative treatment strategy in this setting.

WRKY This Way: A New Way to Tackle Biotic and Abiotic Stress

Alison BentleyNational Institute of Agricutltural BotanyCambridge, United Kingdom
Grand Challenges
Annual Meeting Call-to-Action
1 Mar 2019

Alison Bentley of the National Institute of Agricultural Botany and Ari Sadanandom of the University of Durham both in the United Kingdom will examine whether a new molecular link that they found explaining the increase in plant diseases (biotic factors) associated with high nutrient levels (abiotic factors) can be exploited to maximize wheat crop yield with minimal negative impact on the environment. Wheat, one of the first domesticated food crops, has been grown for over 10,000 years and is critically important to global food supply. Traditionally, crop yields are maximized by applying nitrogen fertilizer to stimulate growth, and fungicides and pesticides to prevent disease. These approaches are expensive and can harm the environment. Another complication is that increasing amounts of nitrogen fertilizer also increases the occurrence of disease. They have identified a group of transcription factors (TFs) - proteins that control expression of specific genes – that appear to protect plants against the fungus Septoria specifically under varying nitrogen levels. To investigate this, they will create transgenic wheat to increase or decrease each TF and explore the effect on disease resistance and growth in different concentrations of nitrogen. Understanding this relationship will allow them to boost plant resistance to disease under high growth conditions, and thereby optimize crop yield with maximal economic gain and minimal environmental impact.

Lactoferrin for Neuroprotection of the Developing Brain

Anne CC LeeBrigham and Women's HospitalBoston, Massachusetts, United States
Grand Challenges
Annual Meeting Call-to-Action
1 Mar 2019

Anne CC Lee and Mandy Brown Belfort of Brigham and Women's Hospital in the U.S. along with Stéphane Sizonenko and Petra Huppi of the University of Geneva in Switzerland will test whether lactoferrin, a breast milk nutrient, can promote growth and reduce injury in the developing infant brain. Of the 15 million annual preterm births, almost a million of the surviving babies have severe neurological defects such as cerebral palsy. However, there are limited treatments available. Breast milk has a positive effect on the infant brain, but the mechanisms for this are unclear. Their preliminary data showed that lactoferrin, a glycoprotein found in breast milk, has a neuroprotective effect in several rat models of neonatal brain injury. They will build on this to study the effect of different concentrations of lactoferrin in the rat models, as well as assaying candidate inflammation, cell death, and neurotrophic factors to identify the molecular mechanisms involved. They will perform a human observational study to associate the different levels of lactoferrin found in breast milk samples from a cohort of mothers of preterm infants at Brigham and Women's Hospital with the infant's brain development as assessed by magnetic resonance imaging. They will also measure lactoferrin levels in samples collected from 100 mothers in Bangladesh to see how they compare. Together, they will generate essential data on lactoferrin for future human clinical trials in low- to middle-income countries.

Makesense Daily: Your Personalized Engagement Journey to Solve the SDGs You Care About

Alizée Lozac'hmeurMakesenseParis, France
Grand Challenges
Global Citizenship
1 Nov 2018

Alizée Lozac'hmeur of Makesense in Paris will develop online mobile and web applications and provide opportunities to engage with experts and funders as part of a tailor-made approach to help young people learn about and solve the health and social issues that matter to them. They will integrate their digital platform, where participants can register their details and issue of interest, with a project database and events calendar to promote collaborations. Users will receive inspiration and advice and be informed of relevant opportunities by frequent emails or mobile phone messages to help them reach their goals. They will integrate the digital services, build a network of community organizers, and launch a marketing strategy to test their approach in France for engaging young people who are interested in solving a specific UN Sustainable Development Goal (SDG).

Young Adult Fiction and Technology to Create a Global Citizenship Process

Anna Gabriella CasalmeNovellySouth Gate, California, United States
Grand Challenges
Global Citizenship
1 Nov 2018

Anna Casalme of Novelly in the U.S. will develop a mobile phone application that combines young adult fiction about social issues with learning tasks and international discussion forums to encourage young people to become global citizens and spark their interest in issues such as gender equality and health. Building on their existing program, they will design and develop the application with specific features, add one novel, and pilot test it, before refining the design and opening it to the public. After three months, they will evaluate their approach by collecting user data such as number of users, their reading progress, and participation in discussion groups.

Young Protectors: Mapping, Communicating, and Intervening to Reduce Disease Risk in Low-Income Communities

Hussein KhalilFederal University of Bahia (UFBA)Rio de Janeiro, Bahia, Brazil
Grand Challenges
Global Citizenship
1 Nov 2018

Hussein Khalil of the Federal University of Bahia in Brazil will provide young people in urban slums with knowledge and tools to identify elements that promote the spread of diseases by rats and mosquitos such as dengue and Zika virus infection, and engage their communities to help combat those diseases. They will recruit 40 young residents from two urban slums to test their approach. The youth will be taught to map rat- and mosquito-infested areas and identify possible causes, such as poor waste disposal, by photographing their environments, and to use tools to track rat movements and insect breeding. They will also use gamification methods to stimulate learning and promote collaborations between the youth and adult residents to identify the most effective interventions. Once simple solutions have been identified, the youth will help to implement them in their community and produce and share progress reports using online and offline tools.

Peace First Youth Challenge: Middle East

Eric DawsonPeace First Inc.Boston, Massachusetts, United States
Grand Challenges
Global Citizenship
1 Nov 2018

Eric Dawson of Peace First Inc. in the U.S. will develop a digital platform that provides tools, online mentors, resources, and funding to help young people aged between 13 and 25 in the Middle East solve critical issues in their communities. Their Youth Challenge Platform approach has already shown initial success for over a hundred projects proposed and run by international youth in the U.S. They will adapt their platform for the Middle East by including different languages and tools, particularly to foster cross-cultural collaborations. They will partner with youth organizations in five to 10 Middle Eastern countries and recruit 50 teams of young people who are interested in solving problems related to the UN sustainable development goals. These teams will be supported through the platform to help them design and implement innovative solutions. Surveys and interviews will be used to evaluate the success of their approach in this region.

The SDG Experience - Student Immersion in SDG Solutions Through Virtual Field Trips

Rimjhim AggarwalArizona State UniversityTempe, Arizona, United States
Grand Challenges
Global Citizenship
1 Nov 2018

Rimjhim Aggarwal of Arizona State University in the U.S. will use a digital learning platform and teaching network to teach young people how to create 360-degree spherical imagery of field sites that function as virtual field trips to share their experiences about specific UN Sustainable Development Goals (SDG) and better engage and teach others. These virtual field trips can be distributed on the internet, giving a large number of viewers the sense of actually being in the field, and are thus valuable teaching tools. However, they require specialized skills and equipment to create them. They will teach young people how to make them by holding a workshop to train 20 honors and undergraduate university students to create three new virtual field trips for local SDGs. These will then be presented to other students as part of a university course via a digital learning platform to evaluate their impact.

Enhancing Community Food Security in Urban and Rural Areas Through Outreach Youth Champions (EFSOYC)

Lucy Kathuri-OgolaKenyatta UniversityNairobi, Kenya
Grand Challenges
Global Citizenship
1 Nov 2018

Lucy Kathuri-Ogola of Kenyatta University in Kenya will train young people to be outreach youth champions to support local smallholder farming households with low food security in Kenya by teaching them new agricultural practices and building financial and social support networks. They will develop a mobile phone application and training platform and test their approach in selected rural and urban areas in Kenya where many smallholder farming families rely heavily on food relief. Sixteen young people who are leaving university will be recruited as outreach youth champions and intensively trained over three weeks on best agricultural practices, and financial and support services such as farmer saving groups. The trained youths will then each go back into their own communities and work with ten households to improve overall social and economic status. They will use surveys to evaluate the effect of their approach on food security.

Creatively Empowering Youth and Kid Agripreneurs as Global Citizens to Achieve Food and Nutrition Security by 2050

Alpha SennonWHYFARMSiparia, , Trinidad and Tobago
Grand Challenges
Global Citizenship
1 Nov 2018

Alpha Sennon of WHYFARM in Trinidad and Tobago, along with Wainella Isaacs, Candace Charles-Sennon, Luke Smith, George Caesar, Akinola Sennon and their partners at TECH4Agri, will engage young people, who are the future feeders of 2050, in agriculture, and develop their knowledge and skills so that they can promote sustainable agriculture and improve food security in Trinidad and Tobago. They will implement four related projects in which participants can win cash prizes. These projects include an eight-week training course for ten professionals aged 18 to 30 that provides mentorship and skills to help develop their business plans, tours of ten primary schools with a local youth theater production company to teach nine to eleven year olds about the nutritional and economic value of baigan (eggplant), including a competition to design their own superheroes and nutritious snacks, and focusing their Agricultural Fun, Museum and Food Factory Park for the under 30's to teach visitors about food and local agricultural products using educational games. They will evaluate each project using surveys and metrics such as numbers of participants and related activity on social media.

Pages

  • First page
  • Previous page
  • Page 1
  • Page 2
  • Currently on page 3
  • Page 4
  • Page 5
  • Page 6
  • Page 7
  • Page 8
  • Page 9
  • …
  • Next page
  • Last page
Sort by:
Date Awarded
Title (A-Z)
10
25
50
100

Contact us

Contact us

  • General Inquiries
  • Media Inquiries

Footer - Receive Updates

Receive updates

  • Sign up for email updates

Footer

  • Privacy Policy and Terms of Use
© 2003-2019. Grand Challenges. All Rights Reserved.

PLEASE REVIEW OUR UPDATED PRIVACY & COOKIES NOTICE

This site uses cookies and similar technologies to store information on your computer or device. By continuing to use this site, you agree to the placement of these cookies and similar technologies. Read our updated Privacy & Cookies Notice to learn more.