Awarded Grants

Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some of the same problems, but from differing perspectives.

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Inhaled Oxytocin: Bringing Gold Standard Postpartum Hemorrhage Prevention to Women in Greatest Need

Victoria OliverMonash UniversityClayton, Victoria, Australia
Grand Challenges for Development
Saving Lives at Birth
19 Dec 2016

This project seeks to substantially expand access to oxytocin through the development of an affordable, simple to administer inhaled oxytocin delivery system. Using innovative technology, inhaled oxytocin is formulated as a fine powder that can withstand the climatic conditions common in tropical regions without the need for refrigeration. The product therefore removes the requirement for cold chain supply and storage, potentially allows task-shifting to lower tier healthcare and community workers and has the potential to save 146,000 lives over 8 years.

Evaluating the Approach to Administration and Dose of Bovine Lactoferrin to Prevent Neonatal Infections in Low Birthweight Newborns in Pakistan

Michael DibleyThe University of SydneySydney, New South Wales, Australia
Grand Challenges for Development
Saving Lives at Birth
19 Dec 2016

The goal of this project is to improve newborn survival among low birth weight (LBW) infants through a daily prophylactic dose of bovine lactoferrin (bLF). A two-stage project will be conducted with formative research followed by randomized controlled trial (RCT) to evaluate the appropriate daily dose of bLF and its efficacy in preventing neonatal infections.

Development and Evaluation of the RELI Delivery System - An Innovative, Simplified, Low-Cost Infusion Pump for Obstetric and Newborn Emergencies

Mike EisensteinProgram for Appropriate Technology in Health (PATH)Seattle, Washington, United States
Grand Challenges for Development
Saving Lives at Birth
6 Dec 2016

PATH's novel infusion pump, the RELI Delivery System, was designed to address many of the barriers surrounding access to infusion pumps in LRS: it does not require electricity or a battery, is inexpensive to manufacture and operate, does not require expensive consumables, and has a simple user interface. We will develop a functional prototype and related job aids to share with stakeholders.

Outpatient Treatment of Neonatal Sepsis by the Rectal Administration of Gentamicin

David McAdamsProgram for Appropriate Technology in Health (PATH)Seattle, Washington, United States
Grand Challenges for Development
Saving Lives at Birth
6 Dec 2016

We propose to investigate the feasibility of a needle-free method of administration for the antibiotic gentamicin via the rectal route. Under this project we would conduct laboratory release studies, preclinical rectal bioavailability studies and stakeholder interviews to assess the feasibility of novel concept. This delivery method would improve access to outpatient treatment of neonatal sepsis in areas serviced by low level healthcare providers and would remove the inherent risks associated with parenteral delivery.

Field Validation of a New Protein-To-Creatinine (PrCr) Strip Test: An Impactful New Tool to Improve Diagnosis of Preeclampsia at the Front Lines of Antenatal Care in Low-Resource Settings

Nicole AdvaniProgram for Appropriate Technology in Health (PATH)Seattle, Washington, United States
Grand Challenges for Development
Saving Lives at Birth
1 Dec 2016

PATH seeks to improve access to improved preeclampsia screening in routine antenatal care (ANC) by addressing the need for a low-cost, accurate proteinuria screening tool to replace the protein-only dipstick as the standard used in routine ANC in LRS. PATH is working in collaboration with LifeAssay Diagnostics, Ltd. (South Africa) to develop and support validation of a simple, low-cost protein-to-creatinine ratiometric urine dipstick test and is seeking to demonstrate the feasibility for implementation and use of the test within routine ANC.

ELICIT: Early Life Interventions for Childhood Growth and Development in Tanzania

Estomih MdumaHaydom Lutheran HospitalHaydom Mbulu, Tanzania
Grand Challenges
All Children Thriving
30 Nov 2016

Microarray Patch for Delivery of a Combination of Antibiotics for the Treatment of Neonatal Sepsis

Mary KearneyQueen's University BelfastBelfast, United Kingdom
Grand Challenges for Development
Saving Lives at Birth
30 Nov 2016

This team proposes to develop and test an innovative microarray patch to deliver a combination of antibiotics for the treatment of neonatal sepsis. An easy-to-use, less-invasive, affordable delivery method for amoxicillin and gentamicin could expand access to lifesaving outpatient antibiotic treatment for infants with severe infection during the neonatal period.

Safer Deliveries Using Point-of-Care Decision Support and Monitoring

Marc MitchellD-Tree InternationalWeston, Massachusetts, United States
Grand Challenges for Development
Saving Lives at Birth
29 Nov 2016

The Safer Deliveries project will improve the ability of nurses and midwives to identify danger signs for a woman and her baby during the critical period of labor and delivery and link these measures to specific decision support rules that guide the health worker in taking corrective action. Using ultra-low-cost disposable ECG leads, D-tree International will build a phone based device that provides continuous tracking of fetal and maternal heart rate and uterine contractions during labor and delivery leading to more timely and effective interventions to save the life of the mother and infant.

Life-saving Instruction for Emergencies (LIFE) Delivered Using Serious Games and mHealth Technologies

Mike EnglishUniversity of OxfordOxford, United Kingdom
Grand Challenges for Development
Saving Lives at Birth
29 Nov 2016

Drawing on 10 years of experience developing and delivering essential newborn care training, this project will develop 3D games using an iterative co-design process in UK and Kenya so it excites users and addresses needs and preferences. This project will explore incentives for learning and develop data capture tools to understand who is playing as well as where and when they are playing. This project will also design a test of the effectiveness of our training in Kenya, explore how to extend the approach to maternal care and plan for dissemination and testing.

Testing and Implementation of Low-cost Breathing Aid for Infants in Tigray, Ethiopia

Anjelica GonzalezYale UniversityNew Haven, Connecticut, United States
Grand Challenges for Development
Saving Lives at Birth
29 Nov 2016

PremieBreathe has built a functional infant breathing aid for $450, one tenth the price of commercial models. The device, a humidified high flow nasal cannula (HHFNC), is the gold standard of non-invasive neonatal respiratory care in high-income countries. With the support of Saving Lives at Birth, PremieBreathe will conduct initial trials at Ayder Referral Hospital in the Tigray region of Ethiopia, and identify design, manufacturing, and distribution partners to prepare for scaled production and dissemination.

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