Skip to main content

Grand Challenges

Bill & Melinda Gates Foundation

Main menu

  • About
  • Challenges
  • Awarded Grants
  • News
  • Grant Opportunities
  • Search

You are here

  1. Home
  2. Awarded Grants
  3. 2009
  4. Grand Challenges Explorations

Print link

Print

Awarded Grants

Filter by Initiative

  • (-) Remove Grand Challenges Explorations filter Grand Challenges Explorations (157)

Filter by Challenge

Filter by Awarded Year

  • 2019 Apply 2019 filter (90)
  • 2018 Apply 2018 filter (70)
  • 2017 Apply 2017 filter (78)
  • 2016 Apply 2016 filter (99)
  • 2015 Apply 2015 filter (121)
  • 2014 Apply 2014 filter (110)
  • 2013 Apply 2013 filter (141)
  • 2012 Apply 2012 filter (203)
  • 2011 Apply 2011 filter (198)
  • 2010 Apply 2010 filter (142)
  • (-) Remove 2009 filter 2009 (157)
  • 2008 Apply 2008 filter (105)

Filter by Country

FILTER INITIAL GRANTS BY FOLLOW-ON FUNDING

  • Funding not received Apply Funding not received filter (133)
  • Funding received Apply Funding received filter (24)

Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some of the same problems, but from differing perspectives.

Sort by:
Date Awarded
Title (A-Z)
10
25
50
100

Reawakening Retrocyclins to Combat Mucosal STIs in Women

Alexander ColeUniversity of Central Florida Research FoundationOrlando, Florida, United States
Grand Challenges Explorations
Mucosal Immunity
16 Nov 2009

Alexander Cole of the University of Central Florida will attempt to restore natural expression of retrocyclins, antiviral peptides whose production in humans has been latent for millions of years. Cole will test inexpensive and widely available antibiotics for their ability to induce production of these retrocyclins, leading to its possible use as a vaginal microbicide.

Diagnosis of Pneumonia Using Sound Recordings

Udantha AbeyratneUniversity of QueenslandBrisbane, Queensland, Australia
Grand Challenges Explorations
Diagnostics
1 Nov 2009

Udantha Abeyratne of the University of Queensland in Australia proposes using low-cost devices such as mobile phones and mp3 players equipped with microphones to record cough and sleeping sounds that do not require direct contact with the patient. Recording will be analyzed using new algorithms in human speech analysis to identify sounds that characterize the presence of pneumonia.

A Novel Virulence-Associated Malaria Drug Target

Paul GilsonBurnet InstituteMelbourne, Victoria, Australia
Grand Challenges Explorations
Malaria Eradication
1 Nov 2009

Paul Gilson of Macfarlane Burnet Institute for Medical Research and Public Health in Australia will study the function of a newly discovered malaria parasite mechanism that exports proteins into host red blood cells in an effort to develop compounds that block this transfer and inhibit parasite growth.

New Screening Technologies for Drug Discovery of Latent Malaria Infections

Ronald QuinnGriffith UniversityBrisbane, Queensland, Australia
Grand Challenges Explorations
Malaria Eradication
1 Nov 2009

Ronald Quinn of Griffith University's Eskitis Institute in Australia and colleagues are seeking to discover chemical fragments drawn from a variety of natural sources that bind to proteins expressed by the malaria parasite in its latent stage and the tuberculosis microorganism. In their Phase I and Phase II research, the team is working on identifying compounds that target proteins involved in key metabolic and energy pathways of latency as the basis for new drug therapies.

Vaccine for HIV Using a Novel Mucosal Vector and Adjuvant

Stephen KentUniversity of MelbourneMelbourne, Victoria, Australia
Grand Challenges Explorations
Vaccines
1 Nov 2009

Stephen Kent and John Stambas of the University of Melbourne in Australia will develop and test an attenuated influenza virus vector with an adjuvant that stimulates natural killer cells. The goal of this approach is to induce robust immunity at mucosal surfaces to HIV, which is important in both prevention and control of infection.

Development of a Genetically-Attenuated Live Malaria Vaccine

Krystal EvansThe Walter and Eliza Hall Institute of Medical ResearchVictoria, Victoria, Australia
Grand Challenges Explorations
Vaccines
1 Nov 2009

Krystal Evans of The Walter and Eliza Hall Institute in Australia will knock out several proteins that support the expression of the major virulence factor for the malaria parasite. Their aim is create a genetically-attenuated live malaria vaccine that elicits a strong immune response against diverse strains of the parasite.

Using Exercise to Improve Pneumococcal Vaccine Efficiency

Kate EdwardsThe University of SydneySydney, New South Wales, Australia
Grand Challenges Explorations
Vaccines
1 Nov 2009

Kate Edwards of University of Sydney in Sydney, Australia will test the theory that brief bouts of exercise consisting of cycling and weight lifting will increase antibody and cell-mediated responses to a pneumococcal vaccination administered immediately after the physical activity.

Microfluidic Isolation of Red Cells Infected With Malaria

Hongshen MaUniversity of British ColumbiaVancouver, British Columbia, Canada
Grand Challenges Explorations
Malaria Eradication
1 Nov 2009

Hongshen Ma of the University of British Columbia in Canada will develop an inexpensive hand-held device consisting of a series of funnels of decreasing size that will separate healthy red-blood cells, which can easily squeeze through openings, from malaria-parasite infected blood cells which become more rigid. A simple integrated optical sensor would then count stained cells in these various stages to determine the state of infection and inform treatment options.

Dendritic Cell Receptor-Targeted Malaria Vaccines

Rajan GeorgePaladin BiosciencesEdmonton, Alberta, Canada
Grand Challenges Explorations
Vaccines
1 Nov 2009

Rajan George of Paladin Biosciences, a division of Paladin Labs Inc. in Canada will produce a vaccine with multiple malaria antigens to target dendritic cell receptors and without the need for an adjuvant, in an effort to induce both antibody and cell-mediated immune responses to the malaria parasite at various stages of the infection.

New Intravaginal Delivery System to Induce Mucosal Immunity

Emmanuel HoUniversity of ManitobaWinnipeg, Manitoba, Canada
Grand Challenges Explorations
Mucosal Immunity
1 Nov 2009

Emmanuel Ho of the University of Manitoba in Winnipeg, Canada will develop a polyether urethane (PU) intra-vaginal ring designed to slowly release the HIV peptide gp120, as well as the cytokine IL-12 as an adjuvant, directly into the vaginal mucosa to stimulate a sustained mucosal immune response.

Pages

  • Currently on page 1
  • Page 2
  • Page 3
  • Page 4
  • Page 5
  • Page 6
  • Page 7
  • Page 8
  • Page 9
  • …
  • Next page
  • Last page
Sort by:
Date Awarded
Title (A-Z)
10
25
50
100

Contact us

Contact us

  • General Inquiries
  • Media Inquiries

Footer - Receive Updates

Receive updates

  • Sign up for email updates

Footer

  • Privacy Policy and Terms of Use
© 2003-2019. Grand Challenges. All Rights Reserved.

PLEASE REVIEW OUR UPDATED PRIVACY & COOKIES NOTICE

This site uses cookies and similar technologies to store information on your computer or device. By continuing to use this site, you agree to the placement of these cookies and similar technologies. Read our updated Privacy & Cookies Notice to learn more.