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Bill & Melinda Gates Foundation

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Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some of the same problems, but from differing perspectives.

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"Lego" like Sanitation System: Pit Latrines Made of Biocomposites

Antonio AvilaUniversidade Federal de Minas GeraisBelo Horizonte, Minas Gerais, Brazil
Grand Challenges Explorations
Sanitation Technologies
15 Apr 2011

Antonio Avila of Universidade Federal de Minas Gerais in Brazil proposes to develop building blocks made from biocomposites that will replace conventional brick and cement constructions for pit latrines. The team will test these building blocks strength and their rate of biodegradation to determine their suitability for building latrines that will decompose once the pits are filled, allowing for the eventual reintroduction of the land for farming and other community uses.

A "Smart Diaphragm" for the Early Detection of Preterm Labor

Larry RandUniversity of California San FranciscoSan Francisco, California, United States
Grand Challenges Explorations
Mothers and Newborns
18 Apr 2011

Larry Rand and colleagues at the University of California, San Francisco in the U.S. will develop a vaginal diaphragm to detect changes in cervical collagen and wirelessly alert health providers before preterm labor begins. This device would identify a new pre-labor "window" during which intervention could reduce mortality and disability resulting from preterm birth among at-risk pregnant women. In Phase I, they designed an easy to use and low-cost device incorporating electrical impedance detection circuitry and fiber optic cable to accurately measure collagen concentration in the cervix of pregnant women over time. Prototypes were built for clinical tests to evaluate the capacity for identifying pregnant women at risk of preterm birth, as well as comfort and acceptability. In Phase II they will optimize the device to make it more robust and user-friendly and expand clinical testing to rural settings in South Africa. They will also develop phone-to-cloud technology for wirelessly collecting the measurements from the device through a mobile phone to a server (cloud) for analysis, and to enable return of the prognosis.

A Birth Control for Nuanced Control

Hope NeighborCamber CollectiveSeattle, Washington, United States
Grand Challenges Explorations
Family Planning
14 Jun 2017

Hope Neighbor of Camber Collective in the U.S. will use applied behavioral research to better understand how and why young, sexually active women who are approaching marriage in West Africa make decisions on family planning products. Women appear to regulate their fertility differently based on their specific situation and needs. Young women who are not yet married tend to use unsafe or ineffective practices such as herbal remedies and abortion. They will recruit women in this group to fill out journals to generate evidence on the nature of their fertility planning needs and identify specific attributes of contraceptives that would fit better into their daily lives. They will also develop hypothetical prototype contraceptives by involving the participants in a card game to identify ways of modifying existing contraceptives, such as enabling over-the-counter availability, and key attributes for future contraceptives that better suit their needs.

A Demand-Driven Supply Chain Technology Demonstrator

Sara GrobbelaarStellenbosch UniversityStellenbosch, South Africa
Grand Challenges Explorations
Health Supply Chains
1 Nov 2017

Sara Grobbelaar of Stellenbosch University in South Africa will develop a platform that can analyze existing real-time data on the stocks of health products at clinics across South Africa and present it to all players in the supply chain to ensure products are available when needed. In partnership with a Northern academic institution they will collect and sort relevant data, analyze trends, and develop decision-making tools. The platform will allow analysis, modeling, and forecasting in the health product supply chain so that unexpected changes such as supply disruptions or epidemics can be accommodated.

A Device to Treat Post Partum Hemorrhage

Glenna BettUniversity at BuffaloBuffalo, New York, United States
Grand Challenges Explorations
Mothers and Newborns
18 Apr 2011

Glenna Bett of SUNY University at Buffalo in the U.S. proposes to develop a device to treat postpartum hemorrhage suitable for use even when medical facilities are absent or minimal, and in non-sterile environments. If successful, this has the potential to reduce perinatal deaths worldwide.

A Disposable Sub-system for Nucleic Acid Sample Preparation Without Instrumentation or User Intervention

Robert CaryMesa Tech International, Inc.Santa Fe, New Mexico, United States
Grand Challenges in Global Health
Point-of-Care Diagnostics
20 Jun 2011

Robert (Bruce) Cary of Mesa Tech International, Inc. in the U.S. proposes to develop nucleic acid purification systems that use a novel configuration of lateral flow materials to bind and wash nucleic acids to yield amplification-­ready samples. These devices could provide purified samples from clinical specimens within minutes without user intervention, instrumentation, electricity or costly materials.

A Household Yeast Biosensor for Cholera

Virginia CornishColumbia UniversityNew York, New York, United States
Grand Challenges Explorations
Synthetic Biology
6 Oct 2011

Virginia Cornish and Nili Ostrov at Columbia University in the U.S. propose to engineer baker's yeast to produce the red tomato pigment lycopene when exposed to the cholera pathogen in drinking water. This safe and simple sensor could be inexpensively manufactured and highly effective for household monitoring of cholera in water by communities at risk for infection.

A Human Endogenous Retrovirus Vaccine to Eliminate Latent HIV

Mario OstrowskiUniversity of TorontoToronto, Ontario, Canada
Grand Challenges Explorations
HIV Infection
29 Sep 2011

Mario Ostrowski of the University of Toronto in Canada will test the theory that alterations of host cells by HIV might also activate human endogenous retroviruses in the same cells. Ostrowski will express antigens of an endogenous retrovirus to study whether they might also mark HIV infected cells, providing a basis for the development of a new HIV vaccine.

A Low-Cost Decentralized Sanitary System

Bin FanResearch Center for Eco-environmental Sciences (RCEES), Chinese Academy of Sciences (CAS); and Chinese Committee for SCOPE (Scientific Committee on Problems of the Environment)Beijing, China
Grand Challenges Explorations
Sanitation Technologies
31 Mar 2011

Bin Fan of the Research Center for Eco-environmental Sciences in China seeks to develop a decentralized sanitation system which uses a low-cost waterless, vacuum system to collect excrement and kitchen waste. The combined waste can then be processed into organic fertilizer.

A Low-Cost Tuberculosis Diagnostic Test for Pregnant Women

Niaina RakotosamimananaInstitut Pasteur de MadagascarAntananarivo, Madagascar
Grand Challenges Africa
Africa-Innovation Seed Grants
28 Sep 2017

Niaina Rakotosamimanana of the Pasteur Institute of Madagascar in Madagascar will develop a low-cost tuberculosis diagnostic and molecular test for pregnant women using dried blood samples drawn from finger pricks. This dried-blood spot based test is minimally invasive, can be used in remote areas where people lack access to all-weather roads and lack of infrastructure that has direct impact on health outcomes. The dried-blood spot can be sent via mail to the health centers for testing without established cold chain methods and meets several of the criteria set by the World Health Organization regarding quality of TB diagnostic tools. Dried-blood samples have a wide range of diagnostic capacity and have been shown to have advantages over other biological samples in terms of cost, ease of collection, transport, and storage.

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