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Interruption of Latency and In Vivo Adenovirus-Mediated Elimination of Macrophages Infected with M. Tuberculosis

Pulmonary macrophages are the principal host of tuberculosis, where it can remain latent and inaccessible to current TB drug therapies. Dmitry Shayakhmetov of the University of Washington will study whether infecting these host cells with adenovirus will induce rapid cell death, reducing TB load and blocking the re-infection cycle.

More information about Explore the Basis of Latency in Tuberculosis (Round 1)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.