In the seventeenth round of Grand Challenges Explorations, proposals were solicited that target the following challenges: Assess Family Planning Needs, Preferences and Behaviors to Inform Innovations in Contraceptive Technologies and Services; Develop Novel Platforms to Accelerate Contraceptive Drug Discovery; Design New Analytics Approaches for Malaria Elimination; Accelerate Development of New Therapies for Childhood Cryptosporidium Infection; Novel Approaches to Characterizing and Tracking the Global Burden of Antimicrobial Resistance; Explore New Solutions in Global Health Priority Areas. The first four challenges are new this round.