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Awarded Grants

Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some of the same problems, but from differing perspectives.

6Awarded Grants

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Challenges: Outdoor Mosquito Control
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Developing an Efficient Real-Time Trapping System for Outdoor Malaria Vector Surveillance

Xiao-Guang Chen, Southern Medical University (Guangzhou, China)
Aug 19, 2022
Grand Challenges China> Outdoor Mosquito Control

Xiao-Guang Chen, Zetian Lai and Chunmei Wang of Southern Medical University in China and their international partner Guiyun Yan of the University of California, Irvine in the U.S. will develop new traps that are more attractive to malaria vectors. They will incorporate the new traps with infrared vector detection, automatic recording and wireless transmission technologies, and test the efficacy of the new trap and the automated malaria vector surveillance apparatus both in the laboratory and in the field. This novel, real-time malaria vector surveillance tool can help efficiently monitor biting behavior, population abundance and transmission dynamics of malaria vectors, and tremendously enhance malaria transmission surveillance and facilitate the evaluation of new vector control measures targeting outdoor malaria vectors.

Developing the Sterile Insect Technique to Control the Urban Malaria Vector Anopheles stephensi

Zhang Dongjing, Sun Yat-sen University (Guangzhou, China)
Aug 19, 2022
Grand Challenges China> Outdoor Mosquito Control

Zhang Dongjing, Zheng Xiaoying, Wu Yu and Wang Gang of Sun Yat-sen University in China together with their international partners Badria El-Sayed, Tellal Ageep, Ammar Hassan and Mohamed Korti all from the National Centre for Research in Sudan, and Jeremy Bouyer, Maiga Hamidou, Hanano Yamada and Adly Abdalla of Insect Pest Control Laboratory in Austria will develop highly specific and environmentally friendly Sterile Insect Technique (SIT) to control outdoor Anopheles mosquitoes. Once the feasibility evaluation is passed, the results will form a systematic technical package of SIT to control Anopheles stephensi and provide the scientific basis and technical support for subsequent field trials of SIT to control this outdoor malaria vector in African countries such as Sudan or other Asian countries.

Development and Application of a Mosquito-Attractive Mycoinsecticide and its Release Device to Control Outdoor Mosquitoes

Weiguo Fang, Zhejiang University (Hangzhou, China)
Aug 19, 2022
Grand Challenges China> Outdoor Mosquito Control

Weiguo Fang of Zhejiang University and Guoding Zhu of Jiangsu Institute of Parasitic Diseases in China together with their international partner Abdoulaye Diabaté of Institut de Recherche en Sciences de La Santé in Burkina Faso, by referring to the widely used small farmer-operated factories for production of entomopathogenic fungal spores in China, will develop a spore production technology for the transgenic Metarhizium strain, which is cost-effective, of low technological bar and can be easily implemented in low-and middle-income countries and regions. A novel bifunctional device will also be provided for outdoor mosquito control. Currently, mycoinsecticides and their release devices are only suitable for indoor mosquito control.

Development of Fungal Mosquitocide for Outdoor Application

GuoXiong Peng, Chongqing University (Chongqing, China)
Aug 19, 2022
Grand Challenges China> Outdoor Mosquito Control

GuoXiong Peng, Yuxian Xia, Yueqing Cao and ZhengBo He of Chongqing University in China together with their international partner Raymond J. St. Leger of the University of Maryland in the U.S. will screen mosquitocidal fungal strains from China and abroad for high-yield virulent and stable production strains against larvae and adults, test the safety of the production strains, optimize solid fermentation medium, fermentation process and the components and proportion in the formulation to develop oil-based fungal mosquitocides for outdoor application. This will help address issues including mosquito resistance and environmental pollution caused by massive use of chemical insecticides.

Development of Novel Vector Control Technology and Product Based on Traditional Chinese Medicine

Biao Jiang, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (Shanghai, China)
Aug 19, 2022
Grand Challenges China> Outdoor Mosquito Control

Biao Jiang, Jianhua Yao, Ping Xing, Jia Li and Wanjun Wang of the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences together with their international partners Ole Skovmand and Sérgio Sousa both of Landcent (Europe) B.V. in The Netherlands will utilize in silico screening to discover mosquito insecticide or repellent compounds in traditional Chinese medicine. At least one safe, environmentally friendly and efficient novel mosquito insecticide or repellent insecticide is expected to be obtained, which will then be used to further develop outdoor vector control technology or products. The development of such mosquito insecticides or repellent compounds will help address insecticide resistance issues and accelerate the global malaria elimination process.

Using Mosquito Anti-Plasmodial Symbiotic Bacteria to Block the Spread of Malaria

Sibao Wang, Institute for Biological Sciences, Chinese Academy of Sciences (Shanghai, China)
Aug 19, 2022
Grand Challenges China> Outdoor Mosquito Control

Sibao Wang of the Institute for Biological Sciences, Chinese Academy of Sciences and Duoquan Wang from the China CDC together with their international partners Abdoulaye Diabaté of Institut de Recherche en Sciences de La Santé in Burkina Faso and Marcelo Jacobs-Lorena of Johns Hopkins University in the U.S. will develop procedures to efficiently introduce a specific bacterium into field mosquitoes in order to evaluate effectiveness of the bacterium spread through mosquito populations and to block parasite transmission in a more realistic setting. Introducing anti-Plasmodial symbiotic bacteria into mosquito populations can potentially transform mosquitoes into ineffective vectors. This unconventional approach has already shown promise in the laboratory.

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.