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Use of HIV Provirus as a Target for Selective Killing Latently Infected Cells

K. Ganesan and Pradip Sen of the Council of Scientific & Industrial Research - Institute of Microbial Technology in India will work to selectively kill cells latently infected with HIV by engineering reagents that would initiate killing only upon specific binding to proviral DNA. If successful, further development could result in a possible cure for latent HIV, which is thought to block the ability of anti-retroviral drugs to fully eradicate the disease. This grant was selected through India's IKP Knowledge Park and their IKP-GCE program.

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.