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Therapeutic Pseudovirus Particles to Target Superspreaders

Highly infectious "superspreaders" often drive the spread of infectious agents but are difficult to identify and treat. Leor S. Weinberger of UCSD and James Lloyd- Smith of UCLA will develop and test engineered pseudoviruses called Therapeutic Infectious Particles (TIPs), which conditionally replicate along with the pathogen as it spreads through populations, but have their virulence elements replaced with therapeutic elements that slow down disease progression and curtail transmission.

More information about Create New Ways of Protecting Against Infectious Diseases (Round 2)

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View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.