Impacts of Antimicrobial Resistance in Low-Income Settings
Alexander Aiken of the London School of Hygiene and Tropical Medicine in the United Kingdom will conduct a pilot Matched Parallel Cohort (MPC) study to examine the impact of antibiotic-resistant infections on individuals specifically in low-income countries in sub-Saharan Africa. Data on antibiotic resistance is virtually absent for this population, even though preliminary data suggests that mortality rates are likely to be higher than for high-income countries. The study will be conducted in two hospitals in Kenya and South Africa. Patients will be classified into four groups, infected or uninfected with antibiotic-resistant bacteria, and infected or uninfected with antibiotic-sensitive bacteria, which is a more rigorous approach for evaluating the impact of resistance in a specific setting. For each patient they will document risk factors associated with antibiotic resistance such as prior antibiotic use, and assess the outcome of the infection after 30 days. This pilot will pave the way for a larger MPC study to more accurately measure the impact of resistance on morbidity and mortality.