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HIV Protease-Dependent Activation of a Cytotoxic Prodrug

For viral replication, HIV viruses are dependent upon proteins, called proteases, to appropriately cleave peptides and form functional viral particles. Craig Crews of Yale University in the U.S. will attempt to exploit these proteases by designing a drug that will cleave only to HIV protease and release a cytotoxin that results in programmed cell death.

More information about Create New Ways to Prevent or Cure HIV Infection (Round 2)

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View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.