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HIV Protease-Dependent Activation of a Cytotoxic Prodrug

For viral replication, HIV viruses are dependent upon proteins, called proteases, to appropriately cleave peptides and form functional viral particles. Craig Crews of Yale University in the U.S. will attempt to exploit these proteases by designing a drug that will cleave only to HIV protease and release a cytotoxin that results in programmed cell death.

More information about Create New Ways to Prevent or Cure HIV Infection (Round 2)