Enhancing Mucosal Immune Response to OPV with IPV

Jacob John of Christian Medical College in India will test the theory that poor immunity generated by the oral poliovirus vaccine (OPV) may be responsible for persistence of the disease. John will study the effect of inactivated poliovirus vaccine (IPV) on gut immunity in children previously given the oral polio vaccine (OPV). Boosting immunity with IPV could result in strategies for accelerating polio eradication.