Deciphering Cellular Heterogeneity in Endometrium Biopsies from Women with Heavy Menstrual Bleeding

Rohini Nair of Gujarat Biotechnology University in India will explore the cellular heterogeneity and molecular pathways associated with heavy menstrual bleeding to better understand the condition, using single-cell transcriptional profiling of the endometrium in patients. In collaboration with Rohina Aggarwal of the Institute of Kidney Diseases and Research Centre in India, 60 premenopausal women with self-identified heavy menstrual bleeding will be recruited: one subgroup with irregular menstrual cycles (half with uterine fibroids and half with adenomyosis) and one subgroup with regular menstrual cycles and no discernible pelvic pathology. A control group of women without clinical symptoms will also be recruited. Single-cell RNA sequencing will be performed on endometrial samples taken during participants' menstrual period to reveal potential biological mechanisms shared and unique across patients with the condition.