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Biomarkers for Bacteremia, Antimicrobial Resistance and Hospital Acquired Infections By NMR and Mass Spectrometry Among Febrile Neutropenic Patients

The project proposes use of metabolomics including High throughput Nuclear Magnetic Resonance (NMR) spectroscopy and Liquid-chromatography mass spectrometry (LC-MS) as a powerful tool for the discovery of biomarkers for differentiating bacteremic cases and non-bacteremic cases among febrile neutropenic Cancer patients to decrease antibiotic consumption, differentiating antimicrobial resistance extended spectrum beta-lactamase (ESBL) present or not based on metabolites and differentiating community acquired blood stream infections and hospital acquired blood stream infections including Central line associated blood stream infections (CLABSI) based on metabolomics. This will greatly reduce the antibiotic consumption, selection of drug-resistant strains, antibiotic associated complications, hospital acquired infections

More information about Grand Challenges India: New Approaches to Characterize the Global Burden of Antimicrobial Resistance

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.