Advancing Non-Clinical Capabilities for Drug Discovery in Eastern Africa

Atunga Nyachieo of the Kenya Institute of Primate Research (KIPRE) in Kenya, with Alfred Botchway of Attentive Science in the U.S., will perform a pilot study as a first step in creating an integrated, preclinical, toxicology testing hub at KIPRE to accelerate drug discovery. The pilot will begin with a toxicology study in rodents to assess existing protocols, including those for dose formulation, oral administration, observation and recording of clinical signs of toxicity, collection and processing of blood and tissue, and histopathology review of tissue slides. This assessment will identify gaps as well as guiding the development of standard operating procedures and of specialized training programs in toxicology and related disciplines.