An Accumulation Rulebook and Vulnerability Atlas for Klebsiella spp.

Andrew Edwards, Edward Tate, Matthew Child, Gad Frankel, Paul Freemont, Marko Storch, Alessandra Russo, Mauricio Barahona and Ramon Vilar of Imperial College London, part of the Fleming Initiative, in the United Kingdom, will use novel genomic and proteomic approaches to identify previously unrecognized targets for new anti-Klebsiella therapeutics. In parallel, the team will use high-throughput accumulation assays, physical chemistry, AI/Machine Learning, data science and molecular bacteriology approaches to decipher the chemical rules of small molecule accumulation in Klebsiella cells. Combined, this work will identify new targets and ensure that small molecule inhibitors accumulate at therapeutic concentrations, paving the way for the development of novel antibiotics active against Klebsiella and other Gram-negative priority pathogens.

This grant is funded by The Wellcome Trust.