The Gates Foundation is part of the Grand Challenges partnership network. Visit <a href="https://www.grandchallenges.org" target="_blank">www.grandchallenges.org</a> to view the map of awarded grants across this network and grant opportunities from partners.

Grand Challenges supports exceptional scientists with the expertise to do breakthrough R&amp;D as well as the experience, networks, and skills to excel as scientific leaders. These champions co-create projects with global partners, mobilize key institutions in their countries, and improve public health in their communities and around the world.

Grand Challenges funds innovations to tackle the biggest problems in global health and development. Since 2004, through the Grand Challenges program, we have supported more than 2500 innovation projects in more than 90 countries.

For more than 20 years, Grand Challenges has built trusted relationships with global health funders and researchers. We tap into this powerful network to create unique scientific collaborations with a transformative impact on people's lives.

Innovation happens all along the journey from idea, to experiment, to product or policy, and finally to delivery at scale in communities. We fund innovation projects while supporting an environment of champions, systems, and partnerships to maximize the impact these projects make in people's lives.

The 4 Pillars of the Grand Challenges Ecosystem

Doing groundbreaking science requires the right mix of institutions, policies, and tools. Grand Challenges works with partners in low- and middle-income countries to build or strengthen the capacities they need to succeed in R&amp;D.

We challenge innovators around the world to work on urgent priorities in global health and development. We issue new challenges regularly and award the most promising proposals with grant funding.&nbsp;

Past Challenges

<h2>Background</h2>Artificial Intelligence (AI) has significant potential to transform healthcare around the world. But as AI technology continues to advance, there is an urgent need to position low- and middle-income countries<a href="#_ftn1" title="" id="_ftnref1" name="_ftnref1">[i]</a> (LMICs) to lead on the design and co-creation of AI-enabled technologies – thereby helping to improve the health and well-being of their women, children, and vulnerable communities. Through this call for proposal, we are emphasizing AI solutions that are locally driven and owned hence more relevant to address the needs of people they intend to serve and more likely to be accepted and used by local communities.Responsible global use of AI entails a safe, equitable, transparent, reliable, and beneficial process that is adhered to with a high level of accountability. As the world rapidly moves to seize AI's opportunities, it is imperative to monitor and mitigate the safety, ethical, equity, and reliability dimensions of AI deployment. This will allow the enormous resilience, creativity, and commitment of researchers, scientists, and policymakers to capture the full capability of AI for lasting good.Grand Challenges (GC) partners including GC Brazil, GC Ethiopia, GC India, GC Senegal, GC South Africa, and GC Africa (pan-African), along with the Bill &amp; Melinda Gates Foundation, the Patrick J. McGovern Foundation, and the Pasteur Network, have jointly discussed the need for an equitable and responsible approach to the use of AI and specifically Large Language Models (LLMs) in LMICs. This call by the various GC partners is a follow-up to the initial call by the Bill &amp; Melinda Gates Foundation representing collaborative steps towards identifying, nurturing, and catalyzing the creativity, energy, and skills that researchers, implementers, governments, and technical partners have demonstrated in solving specific challenges in their countries and regions through LLMs. We are optimistic that this family of related AI RFPs will provide a platform for potentially transformative solutions to improve the lives and conditions for numerous vulnerable communities.Note that this request for proposals is being launched by six Grand Challenges partners: African researchers located in Ethiopia, Senegal, and South Africa, should apply through the corresponding country specific Grand Challenges portal; African researchers located in all other African countries should apply through the Grand Challenges Africa portal; Brazilian researchers located in Brazilian organizations should apply through the Grand Challenges Brazil portal; and Indian researchers located in Indian organizations should apply through the Grand Challenges India portal. Eligible Pasteur Network sites located in Africa should apply through Grand Challenges Africa and Pasteur Network sites located in Brazil should apply through Grand Challenges Brazil. All other eligible Pasteur Network sites (not located in Africa or Brazil) should apply through Grand Challenges Senegal. Please consult the information provided in the subsection referencing geography of interest on the linked partner site to ensure that your application fits the requirements of the RFP you are applying to._______________________________________________________<a href="#_ftnref1" title="" id="_ftn1" name="_ftn1">[i]</a> See <a href="https://data.worldbank.org/country/XO" target="_blank">World Bank – Low Income Countries</a> for definitions.

Grand Challenges India

Grand Challenges India: Catalyzing Equitable Artificial Intelligence (AI) Use to Improve Global Health

<h2>Background</h2>
Artificial Intelligence (AI) has significant potential to transform healthcare around the world. But as AI technology continues to advance, there is an urgent need to position low- and middle-income countries<a href="#_ftn1" title name="_ftnref1" id="_ftnref1">[i]</a> (LMICs) to lead on the design and co-creation of AI-enabled technologies – thereby helping to improve the health and well-being of their women, children, and vulnerable communities. Through this call for proposal, we are emphasizing AI solutions that are locally driven and owned hence more relevant to address the needs of people they intend to serve and more likely to be accepted and used by local communities.
Responsible global use of AI entails a safe, equitable, transparent, reliable, and beneficial process that is adhered to with a high level of accountability. As the world rapidly moves to seize AI's opportunities, it is imperative to monitor and mitigate the safety, ethical, equity, and reliability dimensions of AI deployment. This will allow the enormous resilience, creativity, and commitment of researchers, scientists, and policymakers to capture the full capability of AI for lasting good.
Grand Challenges (GC) partners including GC Brazil, GC Ethiopia, GC India, GC Senegal, GC South Africa, and GC Africa (pan-African), along with the Bill &amp; Melinda Gates Foundation, the Patrick J. McGovern Foundation, and the Pasteur Network, have jointly discussed the need for an equitable and responsible approach to the use of AI and specifically Large Language Models (LLMs) in LMICs. This call by the various GC partners is a follow-up to the initial call by the Bill &amp; Melinda Gates Foundation representing collaborative steps towards identifying, nurturing, and catalyzing the creativity, energy, and skills that researchers, implementers, governments, and technical partners have demonstrated in solving specific challenges in their countries and regions through LLMs. We are optimistic that this family of related AI RFPs will provide a platform for potentially transformative solutions to improve the lives and conditions for numerous vulnerable communities.
Note that this request for proposals is being launched by six Grand Challenges partners: African researchers located in Ethiopia, Senegal, and South Africa, should apply through the corresponding country specific Grand Challenges portal; African researchers located in all other African countries should apply through the Grand Challenges Africa portal; Brazilian researchers located in Brazilian organizations should apply through the Grand Challenges Brazil portal; and Indian researchers located in Indian organizations should apply through the Grand Challenges India portal. Eligible Pasteur Network sites located in Africa should apply through Grand Challenges Africa and Pasteur Network sites located in Brazil should apply through Grand Challenges Brazil. All other eligible Pasteur Network sites (not located in Africa or Brazil) should apply through Grand Challenges Senegal. Please consult the information provided in the subsection referencing geography of interest on the linked partner site to ensure that your application fits the requirements of the RFP you are applying to.
_______________________________________________________
<a href="#_ftnref1" title name="_ftn1" id="_ftn1">[i]</a> See <a href="https://data.worldbank.org/country/XO" target="_blank" rel="noopener noreferrer">World Bank – Low Income Countries</a> for definitions.

Artificial Intelligence (AI) has significant potential to transform healthcare around the world. But as AI technology continues to advance, there is an urgent need to position low- and middle-income countries (LMICs) to lead on the design and co-creation of AI-enabled technologies – thereby helping to improve the health and well-being of their women, children, and vulnerable communities. Through this call for proposal, we are emphasizing AI solutions that are locally driven and owned hence more relevant to address the needs of people they intend to serve and more likely to be accepted and used by local communities.

Grand Challenges India Catalyzing Equitable Artificial Intelligence (AI) Use to Improve Global Health

Grand Challenges Africa

Grand Challenges Africa: Catalyzing Equitable Artificial Intelligence (AI) Use to Improve Global Health

Grand Challenges Africa Catalyzing Equitable Artificial Intelligence (AI) Use to Improve Global Health

Grand Challenges Brazil

Grand Challenges Brazil: Catalyzing Equitable Artificial Intelligence (AI) Use to Improve Global Health

Grand Challenges Brazil Catalyzing Equitable Artificial Intelligence (AI) Use to Improve Global Health

Grand Challenges Ethiopia

Grand Challenges Ethiopia: Catalyzing Equitable Artificial Intelligence (AI) Use to Improve Global Health

Grand Challenges Ethiopia Catalyzing Equitable Artificial Intelligence (AI) Use to Improve Global Health

Grand Challenges Senegal

Grand Challenges Senegal: Catalyzing Equitable Artificial Intelligence (AI) Use to Improve Global Health

Artificial Intelligence (AI) has significant potential to transform healthcare around the world. But as AI technology continues to advance, there is an urgent need to position low- and middle-income countries[i] (LMICs) to lead on the design and co-creation of AI-enabled technologies – thereby helping to improve the health and well-being of their women, children, and vulnerable communities. Through this call for proposal, we are emphasizing AI solutions that are locally driven and owned hence more relevant to address the needs of people they intend to serve and more likely to be accepted and used by local communities.

Grand Challenges Senegal Catalyzing Equitable Artificial Intelligence (AI) Use to Improve Global Health

Grand Challenges South Africa

Grand Challenges South Africa: Catalyzing Equitable Artificial Intelligence (AI) Use to Improve Global Health

Grand Challenges South Africa Catalyzing Equitable Artificial Intelligence (AI) Use to Improve Global Health

<h2>Background</h2>The power of science and innovation can improve global health and development outcomes and dramatically reduce global inequity. Harnessing the potential of Artificial Intelligence (AI) can improve the lives and wellbeing of women, children, and vulnerable communities everywhere.As AI technology continues to swiftly evolve and advance, the global community must move with urgency to ensure low- and middle-income countries<a href="#_ftn1" title="" id="_ftnref1" name="_ftnref1">[i]</a> (LMICs) are included in the co-creation process. AI solutions targeting LMICs must be locally driven and owned and relevant to each person's needs. Local communities must be given the opportunity to provide their own perspective and cultural context so that they can decide on both 1) their own thresholds for safe usage and 2) the overall utility of AI within their own lives.Additionally, LMICs must have equitable access to AI tools and approaches. Responsible global use of AI entails a safe, equitable, transparent, reliable, and beneficial process that is adhered to with a high level of accountability. As the world rapidly moves to seize AI's opportunity, it is imperative to monitor and mitigate the safety, ethical, equity, and reliability dimensions of AI deployment. This will allow the enormous resilience, creativity, and commitment of researchers, scientists, and policymakers to capture the full capability of AI for lasting good.The Bill &amp; Melinda Gates Foundation and Grand Challenges (GC) Partners (including GC South Africa and GC Brazil, with others to be confirmed) have jointly discussed the need for an equitable and responsible approach to the use of AI and specifically Large Language Models (LLMs) in LMICs. This initial call by the Bill &amp; Melinda Gates Foundation represents an early step towards identifying, nurturing, and catalyzing the creativity, energy, and skills that researchers, implementers, governments, and technical partners have demonstrated in solving specific challenges in their countries and regions through LLMs. We are optimistic that this will lead to more investment from the Gates Foundation, GC partners, and other funders, to ensure that this potentially transformative technology improves the lives and conditions of the most vulnerable communities around the world.<h2>The Challenge</h2>This RFP seeks innovative and safe approaches to the use of Large Language Models (ChatGPT-4, or other credible sources with equivalent capability) to build an evidence base across the <a href="https://www.gatesfoundation.org/our-work#program_strategies" target="_blank">Bill &amp; Melinda Gates Foundation Divisions</a> of Global Health, Gender Equality, Global Growth and Opportunity (including Global Education), and Global Development contexts in LMICs.We are looking for projects that can be executed over a 3-month period and will achieve at least one of the following objectives:<ol><li>Demonstrate how the tool can be used to support decision making (in terms of speed, accuracy, inclusivity, quality) in the following domains.<ul><li>Accelerate the pathway from evidence to policy development.</li><li>Accelerate the pathway from policy to implementation.</li><li>Enhance the quality and timeliness of focused communications.</li><li>Improve the quality of resource allocation exercises.</li><li>Decision support for front line workers.</li></ul></li><li>Achieve a better understanding of the opportunities and challenges related to ChatGPT-4, or other credible sources with equivalent capabilities, use in LMICs and how they can be effectively mitigated.</li><li>Conduct observational research that highlights end-user specific applications of ChatGPT-4, or other credible sources with equivalent capabilities, amongst vulnerable populations in LMICs.</li></ol>Ideally the proposal will also:<ul><li>Work on a specific problem that has been identified as a priority in a country or region.</li><li>Contribute to the body of evidence related to AI use in LMICs across health, gender, financial inclusion, agriculture, and education.</li><li>Foster innovation with AI in the interest of supporting decision makers and affected communities.</li><li>Enable an improved understanding of the potential and risks of AI for LMICs.</li><li>Place a strong emphasis on systematically observing, validating, and documenting the process and outcomes for each proposal.</li><li>Conform with global principles of AI use i) to do no harm ii) to leverage technology against the toughest/most relevant problem iii) ensures that projects are led from LMICs even though there may be a high-income country (HIC) partner iv) local voices and ideas are captured throughout the process, and v) there is a dissemination plan of the outcomes of the projects.</li></ul>Priority will be given to proposals that have:<ul><li>an explicit request for an AI supported project,</li><li>those projects that have already completed a pilot before this Grand Challenges call, and/or,</li><li>projects that have lessons/tools that can be transferred to other use cases / situations/ contexts with minimal change.</li></ul>Funding Level:The funding level is a grant of up to USD $100,000.00, for each project, provided to the organization, with a term of up to 3 months.<a href="#_ftn2" title="" id="_ftnref2" name="_ftnref2">[ii]</a> Application budgets should be commensurate with the scope of work proposed. The budget envelope for this Grand Challenge request for proposals is up to $3,000,000.What We Are Looking For:<ul><li>Proposals are led by investigators in LMICs.</li><li>Proposals that demonstrate clear applications of ChatGPT-4, or other credible sources with equivalent capabilities, to address a specific challenge in LMICs related to the SDGs.</li><li>Proposals that demonstrate the grantee has a firm grasp of the application, has done some of the stakeholder mapping, and has an engagement plan to ensure the proposal is successful.</li><li>Proposals that include engagement with affected/supported populations, decision makers.</li><li>Proposals that show the potential for AI to be transformative for application in the <a href="https://www.gatesfoundation.org/our-work#program_strategies" target="_blank">Bill &amp; Melinda Gates Foundation Divisions</a> of Global Health, Gender Equality, Global Growth and Opportunity (including Global Education), and Global Development.</li><li>Proposals that present a high leverage and scalability opportunity.</li><li>Proposals that can easily be adapted or modified either across i) geographies or ii) fields.</li><li>Proposals that outline a clear, feasible and reproducible methodology.</li><li>Proposals that focus on identifying risks to responsible use and develop ways to mitigate those risks.</li><li>Proposals that have timely access to data, decision-maker time and interest in using AI</li><li>Proposals that articulate how the project will lead to impact in the near-term and how those benefits will be sustained past the lifetime of the project.</li><li>Proposals that demonstrate engagement with local and regional decision makers.</li><li>Proposals that are driven by a shared commitment to open science, data sharing, and building collaboration and analysis infrastructure to enable discoveries that will benefit people everywhere.</li></ul>Note: Global partners may be included. However, priority will be given to proposals that demonstrate at least 80% of the funding is going to LMIC institutions and where the investigator is a part of an LMIC institution.We will not consider funding for proposals that:<ul><li>Do not explicitly use/reference the use of ChatGPT-4, or other credible sources with equivalent capabilities, in their project execution.</li><li>Ignore the challenges and context constraints LMICs present.</li><li>Do not have timely access to necessary data, decision-maker time, commitment, and interest (a commendation/request letter will be advantageous).</li><li>Do not demonstrate that the majority of the work proposed will be undertaken by investigators and teams in LMICs.</li><li>Have a weak methodology.</li><li>Have no or weak validation plan.</li><li>Do not provide any thought towards scale up and sustainability.</li><li>Do not engage local and/or regional decision-makers.</li></ul><a href="#_ftnref1" title="" id="_ftn1" name="_ftn1">[i]</a> See <a href="https://data.worldbank.org/country/XO" target="_blank">World Bank – Low Income Countries</a> for definitions.<a href="#_ftnref2" title="" id="_ftn2" name="_ftn2">[ii]</a> Subject to the eligibility requirements in the <a href="https://gcgh.grandchallenges.org/sites/default/files/files/catalyzing_equitable_ai_use_rules_and_guidelines.pdf" target="_blank">Rules &amp; Guidelines</a>.

Grand Challenges

Catalyzing Equitable Artificial Intelligence (AI) Use

<h2>Background</h2>
The power of science and innovation can improve global health and development outcomes and dramatically reduce global inequity. Harnessing the potential of Artificial Intelligence (AI) can improve the lives and wellbeing of women, children, and vulnerable communities everywhere.
As AI technology continues to swiftly evolve and advance, the global community must move with urgency to ensure low- and middle-income countries<a href="#_edn1" title name="_ednref1" id="_ednref1">i</a> (LMICs) are included in the co-creation process. AI solutions targeting LMICs must be locally driven and owned and relevant to each person's needs. Local communities must be given the opportunity to provide their own perspective and cultural context so that they can decide on both 1) their own thresholds for safe usage and 2) the overall utility of AI within their own lives.
Additionally, LMICs must have equitable access to AI tools and approaches. Responsible global use of AI entails a safe, equitable, transparent, reliable, and beneficial process that is adhered to with a high level of accountability. As the world rapidly moves to seize AI's opportunity, it is imperative to monitor and mitigate the safety, ethical, equity, and reliability dimensions of AI deployment. This will allow the enormous resilience, creativity, and commitment of researchers, scientists, and policymakers to capture the full capability of AI for lasting good.
The Bill &amp; Melinda Gates Foundation and Grand Challenges (GC) Partners (including GC South Africa and GC Brazil, with others to be confirmed) have jointly discussed the need for an equitable and responsible approach to the use of AI and specifically Large Language Models (LLMs) in LMICs. This initial call by the Bill &amp; Melinda Gates Foundation represents an early step towards identifying, nurturing, and catalyzing the creativity, energy, and skills that researchers, implementers, governments, and technical partners have demonstrated in solving specific challenges in their countries and regions through LLMs. We are optimistic that this will lead to more investment from the Gates Foundation, GC partners, and other funders, to ensure that this potentially transformative technology improves the lives and conditions of the most vulnerable communities around the world.
<h2>The Challenge</h2>
This RFP seeks innovative and safe approaches to the use of Large Language Models (ChatGPT-4, or other credible sources with equivalent capability) to build an evidence base across the&nbsp;<a href="https://www.gatesfoundation.org/our-work#program_strategies" target="_blank" rel="noopener noreferrer">Bill &amp; Melinda Gates Foundation Divisions</a> of Global Health, Gender Equality, Global Growth and Opportunity (including Global Education), and Global Development contexts in LMICs.
We are looking for projects that can be executed over a 3-month period and will achieve at least one of the following objectives:
<ol>
<li>Demonstrate how the tool can be used to support decision making (in terms of speed, accuracy, inclusivity, quality) in the following domains.
<ul>
<li>Accelerate the pathway from evidence to policy development.</li>
<li>Accelerate the pathway from policy to implementation.</li>
<li>Enhance the quality and timeliness of focused communications.</li>
<li>Improve the quality of resource allocation exercises.</li>
<li>Decision support for front line workers.</li>
</ul>
</li>
<li>Achieve a better understanding of the opportunities and challenges related to ChatGPT-4, or other credible sources with equivalent capabilities, use in LMICs and how they can be effectively mitigated.</li>
<li>Conduct observational research that highlights end-user specific applications of ChatGPT-4, or other credible sources with equivalent capabilities, amongst vulnerable populations in LMICs.</li>
</ol>
Ideally the proposal will also:
<ul>
<li>Work on a specific problem that has been identified as a priority in a country or region.</li>
<li>Contribute to the body of evidence related to AI use in LMICs across health, gender, financial inclusion, agriculture, and education.</li>
<li>Foster innovation with AI in the interest of supporting decision makers and affected communities.</li>
<li>Enable an improved understanding of the potential and risks of AI for LMICs.</li>
<li>Place a strong emphasis on systematically observing, validating, and documenting the process and outcomes for each proposal.</li>
<li>Conform with global principles of AI use i) to do no harm ii) to leverage technology against the toughest/most relevant problem iii) ensures that projects are led from LMICs even though there may be a high-income country (HIC) partner iv) local voices and ideas are captured throughout the process, and v) there is a dissemination plan of the outcomes of the projects.</li>
</ul>
Priority will be given to proposals that have:
<ul>
<li>an explicit request for an AI supported project,</li>
<li>those projects that have already completed a pilot before this Grand Challenges call, and/or,</li>
<li>projects that have lessons/tools that can be transferred to other use cases / situations/ contexts with minimal change.</li>
</ul>
Funding Level:
The funding level is a grant of up to USD $100,000.00, for each project, provided to the organization, with a term of up to 3 months.<a href="#_edn2" title name="_ednref2" id="_ednref2">ii</a> Application budgets should be commensurate with the scope of work proposed. The budget envelope for this Grand Challenge request for proposals is up to $3,000,000.
What We Are Looking For:
<ul>
<li>Proposals are led by investigators in LMICs.</li>
<li>Proposals that demonstrate clear applications of ChatGPT-4, or other credible sources with equivalent capabilities, to address a specific challenge in LMICs related to the SDGs.</li>
<li>Proposals that demonstrate the grantee has a firm grasp of the application, has done some of the stakeholder mapping, and has an engagement plan to ensure the proposal is successful.</li>
<li>Proposals that include engagement with affected/supported populations, decision makers.</li>
<li>Proposals that show the potential for AI to be transformative for application in the <a href="https://www.gatesfoundation.org/our-work#program_strategies" target="_blank" rel="noopener noreferrer">Bill &amp; Melinda Gates Foundation Divisions</a> of Global Health, Gender Equality, Global Growth and Opportunity (including Global Education), and Global Development.</li>
<li>Proposals that present a high leverage and scalability opportunity.</li>
<li>Proposals that can easily be adapted or modified either across i) geographies or ii) fields.</li>
<li>Proposals that outline a clear, feasible and reproducible methodology.</li>
<li>Proposals that focus on identifying risks to responsible use and develop ways to mitigate those risks.</li>
<li>Proposals that have timely access to data, decision-maker time and interest in using AI</li>
<li>Proposals that articulate how the project will lead to impact in the near-term and how those benefits will be sustained past the lifetime of the project.</li>
<li>Proposals that demonstrate engagement with local and regional decision makers.</li>
<li>Proposals that are driven by a shared commitment to open science, data sharing, and building collaboration and analysis infrastructure to enable discoveries that will benefit people everywhere.</li>
</ul>
Note: Global partners may be included. However, priority will be given to proposals that demonstrate at least 80% of the funding is going to LMIC institutions and where the investigator is a part of an LMIC institution.
We will not consider funding for proposals that:
<ul>
<li>Do not explicitly use/reference the use of ChatGPT-4, or other credible sources with equivalent capabilities, in their project execution.</li>
<li>Ignore the challenges and context constraints LMICs present.</li>
<li>Do not have timely access to necessary data, decision-maker time, commitment, and interest (a commendation/request letter will be advantageous).</li>
<li>Do not demonstrate that the majority of the work proposed will be undertaken by investigators and teams in LMICs.</li>
<li>Have a weak methodology.</li>
<li>Have no or weak validation plan.</li>
<li>Do not provide any thought towards scale up and sustainability.</li>
<li>Do not engage local and/or regional decision-makers.</li>
</ul>
<a href="#_ednref1" title name="_edn1" id="_edn1">i</a> See <a href="https://data.worldbank.org/country/XO" target="_blank" rel="noopener noreferrer">World Bank – Low Income Countries</a> for definitions.
<a href="#_ednref2" title name="_edn2" id="_edn2">ii</a> Subject to the eligibility requirements in the <a href="https://gcgh.grandchallenges.org/sites/default/files/files/catalyzing_equitable_ai_use_rules_and_guidelines.pdf" target="_blank" rel="noopener noreferrer">Rules &amp; Guidelines</a>.

Harnessing the potential of Artificial Intelligence (AI) can improve the lives and wellbeing of vulnerable communities everywhere including those of women and children. As AI technology continues to swiftly evolve and advance, the global community must move with urgency to ensure low- and middle-income countries (LMICs) are included in the co-creation process.

This request for proposals seeks innovative and safe approaches to the use of Large Language Models (ChatGPT-4, or other credible sources with equivalent capability). The foundation hopes to build an evidence base on this issue – informed by the communities we serve – to ensure this technology ultimately improves the lives of the world's most vulnerable people. This initial call is an opportunity to identify, nurture, and catalyze the creativity, energy, and skills that researchers, implementers, governments, and technical partners have demonstrated insolving specific challenges in their countries and regions through Large Language Models.