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Solve How to Design Antigens for Effective, Protective Immunity



The molecular revolution in biology, especially the ability to know the sequence of all genes of pathogenic organisms, along with advances in immunology, structural biology and biochemistry, has enabled the rapid identification of antigenic sequences and structures that are the target of a desired immune response.  Once such an antigen is identified, its utility as a vaccine depends upon knowing that giving the antigen to an individual predictably results in the production of an immune response against that aspect of the antigen necessary for specific protective immunity.


We are currently unable to produce antigens that predictably elicit high affinity antibodies or T cell responses against the determined structure of a known or candidate immunogen.


To develop methods to construct antigens that predictably elicit such antibodies or T cell responses by establishing the desired target structure, assuring that it is seen by the immune system and is the conserved epitope presented.

Potential Benefits

  • Rapid development of effective vaccines
  • Reduced development costs

Priority Areas

  • HIV
  • Malaria

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.