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A Small Animal Model to Validate Onchocerca Macrofilaricides

Grand Challenges ExplorationsNeglected Tropical Diseases12 Apr 2013

Warwick Grant of La Trobe University in Australia will develop a small animal parasite model to test candidate drugs for treating the parasitic nematode Onchocerca volvulus, which causes river blindness in humans. They will establish infection of the related parasite Cercopithifilaria johnstoni in rats and evaluate the pathology for similarity to the human disease. The model will then be validated for testing human anti-onchocercal drug candidates by analyzing the effect of drugs with proven success in patients. Once the model has been fully validated, they aim to perform routine assessments of candidate drugs.

More information about New Approaches in Model Systems, Diagnostics, and Drugs for Specific Neglected Tropical Diseases (Round 10)

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Principal Investigator

Warwick Grant

Organization

La Trobe University

Location

Bundoora Victoria
Australia

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