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Shotgun Target Identification

Ronald Quinn of Griffith University in Australia will use anti-malarial compounds as probes to trap protein targets. Mass spectrometry followed by electron capture dissociation (ECD) and electron-transfer dissociation (ETD) will be used to identify individual binding domains between the anti-malarial compounds in the Malaria Box and the malaria parasite proteome that can be used as specific drug targets.

More information about New Approaches for the Interrogation of Anti-Malarial Compounds (Round 9)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.