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Sentinel System for Detection of Schistosome Transmission

Coenraad Adema of the University of New Mexico in the U.S. will develop a device to attract, capture, and display a signal from the parasitic flatworm Schistosoma mansoni in order to determine transmission risks and support control efforts. Adema will confirm the reported attraction of the parasite larvae to particular chemicals (chemoattractants) and then analyze whether the subsequent release of parasite enzymes can induce a color change that can be quantitatively detected using a chromogenic substrate. A prototype floating detection device carrying the most effective chemoattractant and substrate will be developed that also enables recovery of parasite DNA for molecular-based detection.

More information about New Approaches for Detection, Treatment, and Control of Selected Neglected Tropical Diseases (Round 11)

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View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.