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Sentinel Commensals for in situ Temporal Protection against Bacterial Diarrheas

Jun Zhu and Mark Goulian of the University of Pennsylvania in the U.S. propose to use phage display technology to engineer a commensal "sentinel" bacteria that be introduced into the gut flora. Bacterial toxins would be detected by the sentinel commensal, which would bind to the toxin and express enzymes to destroy it.

More information about Create New Ways to Protect Against Infectious Disease (Round 4)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.