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Saving Women's Lives by Simplifying the Treatment for Preeclampsia/Eclampsia with Rectally-Delivered Magnesium Sulfate

We propose to design a gel formulation for sustained release of sulfate (MgSO4) via the rectal route of administration. We will carry out preclinical studies to determine the pharmacokinetics and efficacy of rectal administration of the novel MgSO4 formulation. We will also conduct a user assessment study in Western Kenya among health providers to evaluate the acceptability and feasibility of introducing a rectal delivery method for Preeclampsia and eclampsia. The development of this innovative, non-parenteral delivery system would simplify administration of MgSO4, ensure safe and correct use by providers, and expand access to treatment and prevention of Preeclampsia and eclampsia in rural facilities where it is critically needed.

More information about Saving Lives at Birth (Round 3)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.