Saving the Unborn Child from Malaria: Safety and Efficacy of PfSPZ Vaccine for Pregnant Women and Unborn Children (MRTC)

Malaria is a scourge of pregnant women in developing countries, causing maternal, perinatal and infant mortality. Sanaria's PfSPZ Vaccine prevents malaria infection both in laboratory settings and in Africa. This project will test if the vaccine prevents infection during pregnancy and improves newborn outcomes in order to determine the protective effects of vaccination against the background of a pregnancy registry study enrolling ~900 women each year in Ouelessebougou, Mali.