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Regulation of Gut Health by Phage Infection

Corinne Maurice of McGill University in Canada will use an ecological approach to determine whether bacteriophage (phage), which are viruses that infect bacteria, could be used to restore healthy microbial communities in the gut and thereby reduce stunting in children. They will collect stool samples from infants under two years old from Bangladesh, and compare the types of phage and bacteria found in stunted versus healthy children. Phage from healthy children will be used to infect bacteria from stunted children, and vice versa, to analyze how specific phage affect gut microbes under different conditions, which will demonstrate their potential for treating disease.

More information about Addressing Newborn and Infant Gut Health Through Bacteriophage-Mediated Microbiome Engineering (Round 15)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.