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A Quantum Physics Search for Liver-Stage Antimalarials

David Sullivan of the Johns Hopkins Bloomberg School of Public Health in the U.S., along with Martin N. Martinov of Gradient Biomodeling LLC, will create a quantum physics computer model of liver-stage malaria parasite infection to screen existing commercial drug and compound databases to identify molecules that possess liver-stage specific anti-malarial activity. Those molecules will then be tested in vivo and in vitro, and the ones that are effective will be optimized via computer modeling for future pre-clinical development.

More information about New Approaches for the Interrogation of Anti-Malarial Compounds (Round 9)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.