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Phase-Change Material Freeze Prevention Liner for Vaccines

Nancy Muller from PATH in the U.S. will develop approaches to prevent freezing and thereby destruction of vaccines during cold chain transport. Maintaining vaccines below 8°C while preventing freezing is particularly challenging during their transport in developing countries. In Phase I they designed low-cost liners containing engineered phase change materials that fit existing vaccine carriers and provide a thermal buffer between the vaccines and standard ice-packs. The liners were tested using a new experimental freeze-test protocol, and met WHO performance, quality and safety functional requirements. Connections with vaccine carrier manufacturers were also established to promote the development of compatible vaccine carriers, and one prototype was field-tested in Vietnam for efficacy and ease of use. In Phase II, Pat Lennon, also from PATH in the U.S. will assist cold chain equipment manufacturers and the WHO in product design, testing, and generating demand, to help bring freeze prevention methods for vaccine transport into the market.

More information about Design New Approaches to Optimize Immunization Systems (Round 8)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.