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A Pediatric Immune Enteroid Model of Gut Enteropathy

Marcela Pasetti of the University of Maryland in the U.S. will generate an in vitro model of the gut using intestinal stem cells and immune cells to better mimic the damaged and inflamed guts of young children in developing countries for testing new treatments. Current so-called human enteroid models lack additional relevant cell types found in the intestine, particularly immune cells, which are known to play an important role in gut health and function. They will expose their new miniature pediatric gut model to enteric pathogens and test the ability of human breast milk and bovine hyperimmune colostrum to repair the subsequent damage.

More information about Novel Enabling Tools and Models Supporting Development of Interventions for Enteric Dysfunction (Round 13)

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View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.