• About
  • Partnerships
  • Challenges
  • Awards
  • Grant Opportunities
  • News

One-Dose Vaccine That Prevents Viral Disease in Perpetuity

Daniel Rock of the University of Illinois in the U.S. will develop a multivalent vector vaccine from the ubiquitous Orf virus that can protect ruminants from multiple diseases with a single dose. Current vaccines for a variety of animal diseases that cause substantial economic costs in the developing world are expensive and require multiple doses. The Orf virus has a wide host range, induces robust and long-lasting antiviral immunity, and can be extensively modified to express antigens from a variety of viruses. It can also pass to non-vaccinated animals providing an inexpensive and easy way of protecting large numbers of animals. Rock will begin by constructing an Orf-based vaccine using known antigens of the peste des petits ruminants virus and assay its efficacy in goats or sheep, its long-term persistence, and its ability to transfer to and protect unvaccinated animals.

More information about The One Health Concept: Bringing Together Human and Animal Health for New Solutions (Round 11)

Great ideas come from everywhere.

Sign up for email updates of the latest grant opportunities and awards.

View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.