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Novel Delivery of Protein Anthelmintics

Raffi Aroian of the University of California, San Diego in the U.S. proposes to develop a delivery system for non-toxic, anti-roundworm proteins. With this system, mass production of a safe, potent cure for intestinal Roundworms that is cheap and compatible with global distribution should be possible. This project's Phase I research demonstrated that an anthelmintic protein could be expressed in three food-grade bacterial strains safe for humans. The aim of the Phase II project is to optimize the therapeutic activity and production of this protein in several food-grade bacteria to provide a cure for hookworms and other soil-transmitted helminths that is highly effective, inexpensive, capable of being produced on a large scale, and deliverable in many forms compatible with local customs.

More information about Create New Ways to Protect Against Infectious Disease (Round 5)

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View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.