Global Grand Challenges
  • Grant Opportunities
  • Challenges
  • Awards
  • Champions
  • Partnerships
  • News
  • About

Novel dawadawa therapy for intestinal helminthic infections

Michael K. Chan of the Chinese University of Hong Kong in China and his collaborators will use dawadawa, a staple food in western Africa, as the basis of a novel therapeutic for treating and preventing multiple parasitic worm (helminthic) infections, which are prevelant in developing countries. Dawadawa can be produced by fermenting soyabeans with Bacillus bacteria. By engineering Bacillus to produce parasite-killing (antihelminth) proteins, they can make a staple food with therapeutic properties at low cost. The antihelminth proteins will be encapsulated within crystals that both protects them from degradation in the human gut as well as incorporating a chemical trigger for targeting release in the intestine, where most of the parasites reside.

More information about New Approaches in Model Systems, Diagnostics, and Drugs for Specific Neglected Tropical Diseases (Round 10)

Great ideas come from everywhere.

Sign up for email updates of the latest grant opportunities and awards.

View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.