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Noroviral Replicon:VLP for Gut Mucosal Immunity

Alec Sutherland of Arizona State University in the United States will develop and test a vaccine delivery system that uses Norovirus virus-like particles (VLPs) to deliver desired antigens directly to the gut mucosa. The self-replicating RNA in the VLP will not only encode those antigens, it will also act as an adjuvant by activating several signaling pathways for an enhanced and sustained immune response.

More information about Create New Ways to Induce and Measure Mucosal Immunity (Round 4)

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View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.