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Non-Invasive Detection of Viable Adult Filarial Infections Using the "Capaci-Dance Patch"

Judy Sakanari of the University of California, San Francisco, and Manu Prakash from Stanford University in the U.S. will develop a cheap electromagnetic detection device to non-invasively assess the viability of parasitic nematode worms in infected patients to guide treatment duration. Current methods of detecting viable worms in nodules or the lymphatic system are invasive or expensive. Using animal infection models, they will develop an easy-to-use electronic bandage enabling ultrasensitive detection of capacitance changes caused by movement or physical changes in the adult worms following drug treatment. This could greatly improve the ability to perform in vivo drug studies in animals by being able to non-invasively monitor worm viability over the course of drug treatment and dosing. The bandages will ultimately be tested on humans and could be designed to transfer data remotely for real-time monitoring of the effects of drug treatments in the field.

More information about New Approaches for Detection, Treatment, and Control of Selected Neglected Tropical Diseases (Round 11)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.