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Neurophysiology-Based Platform for Soil-Transmitted Helminth Drug Discovery

Grand Challenges ExplorationsNeglected Tropical Diseases13 Apr 2013

Janis Weeks and Shawn Lockery of the University of Oregon and NemaMetrix in the U.S. have developed a drug discovery platform that they will tailor to identify new drugs for treating soil-transmitted helminthic (STH) infections, which are caused by parasitic nematodes (worms). STH infections are the most common human infection, causing pain, disability, and even death. However, current treatments are inadequate and due to technological barriers there are no new drugs on the horizon. This new platform integrates microfluidics and electrophysiological methods to record electrical signals in parasitic nematodes. This technology provides the first semi-automated, medium-throughput platform for identifying new drugs that kill worms by disrupting neuromuscular function.

More information about New Approaches in Model Systems, Diagnostics, and Drugs for Specific Neglected Tropical Diseases (Round 10)

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Principal Investigator

Janis Weeks

Organization

University of Oregon

Location

Eugene, Oregon
United States

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