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Nanocrystal Therapeutics for the Treatment of Multi-Drug Resistant Pathogens

Dan Feldheim of the University of Colorado in the U.S. will test his hypothesis that gold nanocrystals coated with drug compounds can effectively inhibit protein- protein interactions that often drive disease pathogenesis, will be less susceptible to evolutionary mechanisms that lead to drug resistance, and offer enhanced drug delivery characteristics. This project's Phase I research demonstrated that gold nanocrystals can be tailored to circumvent many viral and bacterial evolutionary drug resistance mechanisms. In Phase II, he is now studying the ability of small molecule-coated nanoparticles to withstand resistance mechanisms of Mycobacterium tuberculosis (TB).

More information about Create Drugs and Delivery Systems to Limit Drug Resistance (Round 1)

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View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.