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Missiled Bacteriophage Enabling Controlled Infant Gut Health

Baojun Wang of the University of Edinburgh in the United Kingdom will engineer bacteriophages to selectively target gut pathogens such as Shigella and Salmonella that cause widespread environmental enteropathy in infants in developing countries. They will program the CRISPR-Cas9 (clustered, regularly interspaced short palindromic repeats-CRISPR-associated proteins) nucleases to cut the chromosomes of the target pathogens, and test their ability to block infection in a mouse gut colonization model while leaving the non-pathogenic and often beneficial bacteria largely intact.

More information about Addressing Newborn and Infant Gut Health Through Bacteriophage-Mediated Microbiome Engineering (Round 15)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.