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Metabolosomes: The Organizing Principle of Latency in Mtb

Kyu Rhee of Weill Cornell Medical College in the U.S. will test the theory that the tuberculosis (TB) bacterium uses protein-based structures termed metabolosomes to enter into, maintain, and exit from latency or non-replication. Understanding how metabolosomes work will aid in development of drugs that target TB. This project's Phase I research demonstrated that latent or non-replicating M. tuberculosis undergo a metabolic remodeling that is accompanied by the reversible formation of enzyme-based metabolosomes. In Phase II, Rhee and colleagues will characterize and determine how essential these metabolosomes are to entering and exiting latency or non-replication, which could help identify them as targets for new drug therapies for TB.

More information about Explore the Basis of Latency in Tuberculosis (Round 2)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.