• About
  • Partnerships
  • Challenges
  • Awarded Grants
  • Grant Opportunities
  • News

Measurement of Somatic Hypermutation Induced By C3d Adjuvant

Sai Reddy of ETH Zürich in Switzerland will study how low levels of the immune system-stimulating molecule C3d attached to a protein from a pathogen (antigen) can lead to the production of large numbers of pathogen-fighting antibodies and thereby boost the efficacy of vaccines. They hypothesize that it involves stimulating the process of somatic hypermutation in antibody-producing B cells, which results in high titers of antibodies that can bind very strongly to the target pathogen. They will generate the C3d protein fused to a number of different antigens, use them to immunize mice, and subsequently analyze somatic hypermutation using high-throughput sequencing of antibodies and bioinformatics methods.

More information about Explore New Solutions in Global Health Priority Areas (Round 16)

Great ideas come from everywhere.

Sign up for email updates of the latest grant opportunities and awards.

View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.