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Measurement of Somatic Hypermutation Induced By C3d Adjuvant

Sai Reddy of ETH Zürich in Switzerland will study how low levels of the immune system-stimulating molecule C3d attached to a protein from a pathogen (antigen) can lead to the production of large numbers of pathogen-fighting antibodies and thereby boost the efficacy of vaccines. They hypothesize that it involves stimulating the process of somatic hypermutation in antibody-producing B cells, which results in high titers of antibodies that can bind very strongly to the target pathogen. They will generate the C3d protein fused to a number of different antigens, use them to immunize mice, and subsequently analyze somatic hypermutation using high-throughput sequencing of antibodies and bioinformatics methods.

More information about Explore New Solutions in Global Health Priority Areas (Round 16)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.