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Massive Sample Pooling and Sequencing for Prevalence Rates

Timothy Julian of the Swiss Federal Institute of Aquatic Science and Technology (EAWAG) in Switzerland will develop a low-cost approach to monitor the development of resistance to antibiotics, which is a major public health concern. Identifying antibiotic resistance requires sequencing and with current protocols is costly. To address this, they will first enrich samples for 30 antibiotic resistance genes using oligo-coated magnetic beads to increase the efficiency of the sequencing and substantially reduce the cost per sample. They will optimize the gene enrichment step by testing different oligos and protocols.

More information about Novel Approaches to Characterizing and Tracking the Global Burden of Antimicrobial Resistance (Round 16)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.