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Low Cost, Needle-Free Treatment for Post-Partum Haemorrhage

Michelle McIntosh of Monash University in Australia will develop and test the stability and efficacy of a dry powder formulation of the drug oxytocin, which is used to treat post-partum bleeding, in an inexpensive inhalant format that would be a needle-free, non-refrigerated option suitable for use in remote areas with limited training. The project's Phase I research provided proof-of-concept that the inhalation of pharmaceutically engineered particles of oxytocin can rapidly induce therapeutically-relevant contraction of uterine smooth muscle. During Phase II, McIntosh and a team will continue to improve the stability of the oxytocin powder and further characterize the relationship between oxytocin delivered to the lungs and effectiveness in a preclinical model.

More information about Create New Technologies to Improve the Health of Mothers and Newborns (Round 5)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.