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Intestinal Alkaline Phosphatase to Treat and Prevent Diarrhea

Madhu Malo of Massachusetts General Hospital/Harvard Medical School in the U.S. will investigate whether maintaining the normal intestinal commensal bacteria using oral supplementation of intestinal alkaline phosphatase (IAP), a small intestinal brush-border enzyme, will prevent or cure infection by pathogenic bacteria. A successful project would generate a universal prophylactic and therapeutic strategy against diarrheal diseases.

More information about Create New Ways to Induce Mucosal Immunity (Round 3)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.