• About
  • Partnerships
  • Challenges
  • Awards
  • Grant Opportunities
  • News

Interrogating AntiMalarials Using Optogenetics Technology

Choukri Ben Mamoun of Yale University in the U.S. will employ optogenetics technology to identify antimalarial compounds in the so-called Malaria Box collection that specifically target membrane biogenesis in the parasite Plasmodium falciparum, which transmits the disease. Compounds targeting membrane biogenesis are known to inhibit both infection and transmission, as well as potently inhibiting drug-resistant parasites, which are becoming increasingly common. The optogenetics approach involves genetically engineering parasites to carry lipid biosensors composed of a fluorescent protein that can bind to a specific membrane phospholipid. Levels of phospholipids can then be monitored and quantified in the presence of a drug to identify those that affect membrane biogenesis.

More information about New Approaches for the Interrogation of Anti-Malarial Compounds (Round 10)

Great ideas come from everywhere.

Sign up for email updates of the latest grant opportunities and awards.

View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.