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Inducing Autophagy in Dendritic Cells By DNA Delivery

Tanapat Palaga of Chulalongkorn University in Thailand seeks to create a novel DNA vaccine delivery system that targets dendritic cells in GI mucosal tissues. Using chitosan nanoparticles to encapsulate DNA plasmid and protect it from stomach acid, this potential vaccine construct will contain both an antigen and an autophagy- inducing gene to enhance the vaccine's efficacy.

More information about Create New Ways to Induce Mucosal Immunity (Round 3)

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View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.