Inducing Autophagy in Dendritic Cells By DNA Delivery
Tanapat Palaga of Chulalongkorn University in Thailand seeks to create a novel DNA vaccine delivery system that targets dendritic cells in GI mucosal tissues. Using chitosan nanoparticles to encapsulate DNA plasmid and protect it from stomach acid, this potential vaccine construct will contain both an antigen and an autophagy- inducing gene to enhance the vaccine's efficacy.