Identification and Mechanistic Analysis of Novel Antibacterial Compounds

Xue Liu of Tsinghua University in China will identify antibacterial small molecules against the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) by screening compound libraries that contain compounds with novel chemical scaffolds. They will then use the identified antibacterials as probes to find new targets for antibiotic development. The current data include the discovery of two bacteriocidal compounds with novel scaffold structures.